Lipid-based nanosystems for atherosclerosis treatment: Evolving approaches and novel therapeutic strategies [0.03%]
基于脂质的纳米系统在动脉粥样硬化治疗中的新兴方法及新型治疗策略
Lijun Li,Mengran Guo,Zhangyu Wang et al.
Lijun Li et al.
Atherosclerosis, the leading cause of cardiovascular diseases, has become increasingly prevalent worldwide, driving the need for innovative therapeutic strategies to improve clinical outcomes. Lipid-based nanosystems have emerged as promisi...
Fluorescence bioimaging of drug nanocarriers based on Förster resonance energy transfer, aggregation-induced emission and aggregation-caused quenching [0.03%]
基于福尔特共振能量转移、聚集诱导发光和聚集淬灭的药物纳米载体的荧光生物成像
Runtong Zhang,Haisheng He,Yi Lu et al.
Runtong Zhang et al.
The introduction of environment-responsive probes has greatly improved the accuracy of fluorescence bioimaging in evaluating drug nanocarriers. This review highlights the key roles of Förster resonance energy transfer, aggregation-induced ...
FTO-mediated m6A depletion drives prenatal prednisone exposure-induced cortical neurogenesis deficits and long-term anxiety-depression-like behaviors in offspring [0.03%]
FTO介导的m6A缺乏驱动孕期皮质醇暴露诱导的后代皮层神经发生缺陷及长期焦虑抑郁行为
Cuiping Qi,Juanjuan Guo,Sen Zhu et al.
Cuiping Qi et al.
Prednisone is widely used to treat pregnancy-complicated autoimmune diseases, but the impact of prenatal prednisone exposure (PPE) on offspring neurodevelopment is unclear. Clinical follow-up using the Ages and Stages Questionnaires (ASQ:SE...
Yiyang Wu,Nannan Wang,Ping Xiong et al.
Yiyang Wu et al.
The global pharmaceutical drug delivery market is forecasted to grow to USD 2546.0 billion by 2029. The expanding pharmaceutical market urgently needs a more efficient drug research and development paradigm. Artificial intelligence (AI) is ...
In situ rewiring TAMs as annihilators by "Spark-relay" nanoinitiator with flexible reactant ratio for amplifying solid tumor immunotherapy [0.03%]
利用比率可调的“火花-传递”型纳米引发剂原位重编程肿瘤相关巨噬细胞以增强实体瘤免疫治疗效应
Xinping Luo,Yingmeng Jiang,Qing Zhang et al.
Xinping Luo et al.
Tailoring tumor-associated macrophages (TAMs) into the tumoricidal phenotype represents a high-profile strategy for tumor immunotherapy. However, the existing TAMs repolarization strategies are restricted by hostile microenvironmental stres...
Wei Wu,Wei He,Zongming Zhao
Wei Wu
Outer membrane vesicles: Versatile nanocarriers for therapeutic delivery and immune modulation [0.03%]
外膜囊泡：用于药物递送和免疫调节的多功能纳米载体
Jinlong Yang,Tang Wang,Yuekai Zheng et al.
Jinlong Yang et al.
Outer membrane vesicles (OMVs) are nanoscale lipid-bilayer vesicles naturally released by Gram-negative bacteria. By packaging membrane proteins, lipopolysaccharide-derived pathogen-associated molecular patterns, nucleic acids, and metaboli...
Pathology-directed drug delivery strategies: How to overcome blood-brain barrier for the treatment of brain diseases [0.03%]
病理学定向药物输送策略：如何克服血脑屏障以治疗脑疾病
Yun Chen,Xinzhu Sun,Yilong Xi et al.
Yun Chen et al.
Despite the different degrees of blood-brain barrier (BBB) damage in diverse brain diseases, it remains a formidable barrier that restricts most drugs from penetrating the brain. A comprehensive understanding and elucidation of the disease-...
Astrocytes in predictive processing of emotion: Kir4.1 as precision modulator of social interaction [0.03%]
星形胶质细胞在情绪预测加工中的作用：Kir4.1通过调节社交互动的精确性来影响精神分裂症
Aakash Basu,Alfred P Kaye
Aakash Basu
Albumin-based nanocarriers: Singularities, synthesis methods, clinical relevance and targeting strategies in cancer [0.03%]
基于白蛋白的纳米载体：特异性、合成方法、临床相关性和癌症靶向策略
Edgar Pérez-Herrero,Alberto Fernández-Medarde,Juan M Irache
Edgar Pérez-Herrero
Proteins have emerged as highly promising biomaterials for the design of drug-loaded nanocarriers due to their biocompatibility, biodegradability and reduced immunogenicity. Among them, albumin stands out as the most widely used due to its ...