Curcumin ameliorates metabolic dysfunction-associated steatotic liver disease via targeting triokinase/FMN cyclase to regulate the expression of glycerol-3-phosphate acyltransferase 3: Integration of chemical proteomics and transcriptomics [0.03%]
姜黄素通过靶向三磷酸甘油激酶/黄素单核苷酸cyclase调节甘油-3-磷酸酰基转移酶3的表达来改善与代谢功能障碍相关的脂肪变性肝病：化学蛋白质组学和转录组学的整合
Chongyan Zhao,Pan Li,Jie Shi et al.
Chongyan Zhao et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, posing public health risks from potential irreversible liver damage. Curcumin (Cur), a polyphenolic compound from Zingiberaceae and A...
Extracellular vesicles: Revolutionizing targeted therapy for ischemic stroke [0.03%]
细胞外囊泡：针对缺血性卒中的靶向治疗革命
Ju Bai,Jingshu Yang,Wei Liu et al.
Ju Bai et al.
Ischemic stroke (IS) remains a leading cause of global death and disability, with treatment effectiveness limited by its complex mechanisms, which include blood-brain barrier (BBB) disruption, neuroinflammation, excitotoxicity, oxidative st...
Advanced oral drug delivery systems: Current challenges and emerging technologies [0.03%]
先进的口服药物递送系统：当前的挑战与新兴技术
Satomi Onoue,Kohei Yamada,Hideyuki Sato
Satomi Onoue
Oral dosage is the most commonly used and preferred method of drug administration due to its several advantages, including non-invasiveness, patient adherence, and ease of use. However, oral bioavailability can be influenced by several fact...
Saisai Tian,Yixue Liang,Jinbo Zhang et al.
Saisai Tian et al.
Gene essentiality (synonymous with dependency) mapping reveals therapeutic vulnerabilities for intractable oncogenes, yet integrated platforms bridging CRISPR functional genomics with drug discovery remain limited. To address this gap, we d...
Identification of HMGB1 as a target of 3- O-benzoyl-20-deoxyingenol in NSCLC therapy using integrated ABPP and SIP [0.03%]
基于ABPP与SIP联合分析技术在NSCLC治疗中鉴定3-O-苯甲酰基-20-去氧印防己毒素的目标HMGB1蛋白质
Yaxu Wang,Yan Liu,Yuan Zhuang et al.
Yaxu Wang et al.
Exploring the therapeutic potential of cannabidiol in soft tissue wound healing: Delivery strategies and anti-inflammatory pathways [0.03%]
探讨大麻二酚在软组织伤口愈合中的治疗潜力：递送策略和抗炎途径
Arita Dubnika,Inga Jurgelane,Andra Grava-Ceplite et al.
Arita Dubnika et al.
This review explores the molecular and cellular pathways of soft tissue wound healing and the potential therapeutic use of the non-psychotropic cannabinoid cannabidiol (CBD), integrating findings from in vitro and in vivo preclinical studie...
Crystal engineering for poorly water-soluble drugs: From design to applications [0.03%]
药物结晶工程：从设计到应用
An Chen,Yayun Peng,Zhuangzhuang Chen et al.
An Chen et al.
The limited aqueous solubility of active pharmaceutical ingredients (APIs) remains a major challenge in drug development, severely compromising clinical performance. Crystal engineering has emerged as a powerful and versatile approach to ad...
Deep eutectic solvents@enteric technology for orally delivering anticoagulant macromolecule drug [0.03%]
抗凝大分子药物口服给药用的深共晶溶剂@肠溶技术
Xiaoke He,Jiahui Zou,Yuxin Jiang et al.
Xiaoke He et al.
Low-molecular-weight heparin (LMWH) is one of the most clinically used anticoagulants to improve venous circulation. However, LMWH requires repeated injections, leading to poor medication compliance. Herein, we developed a deep eutectic sol...
A spatiotemporal selective bioinspired hybrid system engineered for preventing post-thrombolysis recurrence by inhibiting the ferroptosis pathway and reprogramming macrophages [0.03%]
一种时空选择性仿生杂化系统用于防止溶栓后再狭窄通过抑制铁死亡通路和重塑巨噬细胞表型而设计合成
Tianjiao Hao,Bin Gao,Yuanyuan Zhou et al.
Tianjiao Hao et al.
Cardiovascular diseases induced by arterial thrombosis, such as myocardial infarction and ischemic stroke, have gradually emerged as critical threats to human life and health. Sequentially targeted delivery systems are highly desired to be ...
Cuproptosis-based nanomedicine in cancer metastasis synergistic therapy [0.03%]
基于杯状细胞坏死的纳米药物在癌症转移协同治疗中的应用
Kan Zhou,Zi-Zhan Li,Yi Liu et al.
Kan Zhou et al.
Cancer metastasis is a critical indicator of cancer progression and serves as a major cause of cancer-related deaths. Cuproptosis is a novel form of regulated cell death proposed in 2022. Unlike ferroptosis and other known regulated cell de...