Inhalational therapy of pulmonary infection via macrophage-targeted nanoemulsions [0.03%]
针对巨噬细胞的纳米乳剂肺部感染吸入疗法研究
Hairui Wang,Jinghong Xian,Guonian Zhu et al.
Hairui Wang et al.
The dynamic immune landscape within the tuberculous (TB) granuloma microenvironment critically governs antibiotic penetration efficiency, bacterial persistence, and long-term therapeutic outcomes. Herein, we present a macrophage-targeted in...
A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway [0.03%]
一种广谱抗呼吸道病毒药物的新发现途径：管花肉苁蓉苷II通过调节宿主因素PACT增强RIG-I抗病毒通路
Xian Liu,Dan Xie,Mengyao Cui et al.
Xian Liu et al.
PACT (PKR activating protein)/PRKRA is a quintessential double-stranded RNA (dsRNA) binding protein that has recently surfaced as a novel and compelling antiviral target, exhibiting resistance against a spectrum of respiratory viruses. Desp...
Small molecules modulate the biomolecular condensates and liquid‒liquid phase separation [0.03%]
小分子调节生物分子凝聚体和液-液相分离
Kaiyue Lian,Fajun Nan
Kaiyue Lian
Phase separation of biological macromolecules is a ubiquitous cellular mechanism for concentrating and compartmentalizing biochemical reactions. Emerging evidence reveals that biomolecular condensates formed via liquid-liquid phase separati...
Analysis of intratumoural bacteria: Opportunities and challenges for cancer therapy [0.03%]
肿瘤内细菌分析：癌症治疗的机遇与挑战
Xiaowen Jiang,Chunyan Zhang,Simeng Cao et al.
Xiaowen Jiang et al.
Intratumoural bacteria have been shown to play conflicting roles within tumours, especially in the modulation of immune responses. Moreover, bacteria have been linked to a variety of cancer types and have different prognostic values dependi...
Erratum: Author correction to "Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy" [Acta Pharm Sin B 14 (2024) 3205-3217] [0.03%]
勘误：关于“基于TLR-2和ICB协同作用的CRISPR/Cas9仿生递送三萜模板自组装纳米系统增强肝细胞癌免疫治疗”作者更正[药学学报（英文版）14 （2024）3205-3217]
Bing-Chen Zhang,Chun-Mei Lai,Bang-Yue Luo et al.
Bing-Chen Zhang et al.
[This corrects the article DOI: 10.1016/j.apsb.2024.04.033.]. © 2026 The Authors.
Published Erratum
Acta pharmaceutica Sinica. B. 2026 May;16(5):3254-3255. DOI:10.1016/j.apsb.2026.03.012 2026
Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases [0.03%]
靶向非凋亡的调节细胞死亡(RCD)以治疗神经退行性疾病
Wenzhe Zhao,Yue Lai,Zhijia Li et al.
Wenzhe Zhao et al.
Regulated cell death (RCD) is well-known as a controlled form of cell death regulated by one or more cascading signaling pathways. Over the past few decades, increasing evidence has implicated various non-apoptotic forms of RCD in neurons-i...
Red blood cell damage defines the etiology of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids [0.03%]
红血球损伤定义了吡咯里西啶生物碱引起的肝窦状障碍综合征的病因
Zijing Song,Yisheng He,Wei Zhang et al.
Zijing Song et al.
Hepatic sinusoidal obstruction syndrome (HSOS), a life-threatening liver disease characterized by sinusoidal endothelial cell (LSEC) damage, is frequently caused by pyrrolizidine alkaloid (PA) exposure present in numerous herb or food produ...
Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux [0.03%]
靶向作用于SCAMP2的天然产物auxarconjugatin B通过恢复天冬氨酸代谢通量治疗胶质母细胞瘤
Changhui Shang,Wan Li,Qianlun Pu et al.
Changhui Shang et al.
Glioblastoma (GBM), the most aggressive primary brain malignancy, presents an urgent need for novel therapeutic targets addressing metabolic reprogramming in tumor progression. Natural product-based molecular probes have emerged as powerful...
Biomimetic liposomes synergize with high-intensity focused ultrasound to induce ferroptosis in tumors [0.03%]
类脂体与高强度聚焦超声协同诱导肿瘤细胞铁死亡
Ruizhe Xu,Xuejing Li,Xiaomin Su et al.
Ruizhe Xu et al.
The efficient targeted delivery and on-demand release of nanomedicines still present significant challenges in tumor therapy. In the present study, we developed a novel strategy of tumor ferroptosis therapy through the synergistic effect of...
Reblastatin as a neuroprotective agent in temporal lobe epilepsy and excitotoxic conditions of Alzheimer's disease and Parkinson's disease [0.03%]
雷伯斯坦作为颞叶癫痫及阿尔茨海默病和帕金森病兴奋毒性条件下的神经保护剂
Xiuneng Zhang,Xiaolin Yu,Longze Sha et al.
Xiuneng Zhang et al.
Previous studies have shown that heat shock protein 90 (Hsp90) inhibitors can reduce seizures in temporal lobe epilepsy (TLE) by upregulating excitatory amino acid transporter 2 (EAAT2, also known as GLT-1). While the Hsp90 inhibitor 17-AAG...