Agonist-specific FPR1 conformational change prevents receptor recycling and promotes targeted protein degradation [0.03%]
特异性的FPR1构象变化防止受体回收并促进目标蛋白质降解
Junlin Wang,Qiwen Liao,Geng Chen et al.
Junlin Wang et al.
Recycling of internalized cell surface receptors is critical for membrane transport and receptor-mediated signaling. Formyl peptide receptor 1 (FPR1) plays important roles in host defense and inflammatory tissue injury. Here we report that ...
Urate transporters: Structural mechanisms and therapeutic opportunities in drug development [0.03%]
尿酸转运体：结构机制及药物研发中的治疗机会
Qian Yang,Shujing Xu,Xiaoyu Shi et al.
Qian Yang et al.
Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases [0.03%]
基于免疫细胞的抗炎药物治疗研究进展
Yuxin Yang,Jinhu Liu,Jie Liu et al.
Yuxin Yang et al.
Inflammation-related diseases account for over 50% of global disease-associated mortality; the core pathological mechanisms of these diseases are closely linked to functional dysregulation of immune cells such as macrophages and T cells. Ab...
Multistage responsive microneedle delivery system loaded oncolytic virus for topical therapy of melanoma [0.03%]
用于局部治疗黑色素瘤的多级响应型微针递送系统载瘤内溶性病毒
Zhongjie Wang,Zewei Yan,Hanlin Chen et al.
Zhongjie Wang et al.
Melanoma, the most aggressive form of skin cancer, remains a formidable therapeutic challenge. While oncolytic viruses (OVs) exhibit promising antitumor potential, their efficacy is often limited by insufficient intratumoral viral replicati...
Mechanistic insights and therapeutic advances in antiviral strategies against African swine fever virus [0.03%]
非洲猪瘟病毒抗病毒策略的机制研究进展
Huihan Shao,Quanjie Li,Shan Cen
Huihan Shao
African swine fever virus (ASFV) causes a highly contagious and lethal disease in domestic and wild pigs, posing a significant threat to global swine production. The lack of effective vaccines or antiviral therapies underscores the urgent n...
Targeting cancer-associated fibroblast-activated HGF/c-MET pathway inhibits extrahepatic cholangiocarcinoma progression and restores gemcitabine therapeutic sensitivity [0.03%]
靶向作用于癌相关成纤维细胞活化的HGF/c-MET通路抑制肝外胆管癌的进展并恢复吉西他滨治疗敏感性
Mingzhen Bai,Ping Yue,Wenkang Fu et al.
Mingzhen Bai et al.
Cholangiocarcinoma (CCA) is a markedly desmoplastic tumor, with extrahepatic CCA (eCCA) being the most prevalent subtype. The nonspecific clinical manifestation and early metastatic potential result in a persistently poor overall prognosis....
Non-viral delivery of genome-editing tools for treatment of genetic disorders [0.03%]
用于遗传病治疗的基因编辑工具非病毒递送系统
Jiamin Yang,Yuxuan Chen,Xiaohong Chen et al.
Jiamin Yang et al.
Pathogenic mutations within protein-coding regions of genomic DNA can disrupt protein structure and lead to hereditary disorders. Genome-editing technologies, particularly those based on clustered, regularly interspaced, short palindromic r...
Cell-based regenerative interventions in Parkinson's disease: Overcoming pharmacological limitations [0.03%]
细胞替代治疗在帕金森病中的应用：克服药物局限性
Ana Lizeth Padilla,José L Lanciego,Miquel Vila et al.
Ana Lizeth Padilla et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and the pathological aggregation of α-synuclein. While current pharmacological therapies provide symptomatic relief...
Advances in GLP-1 receptor agonists delivery systems for obesity and diabetes [0.03%]
肥胖和糖尿病的GLP-1受体激动剂输送系统的最新进展
Mehrnaz Abbasi,Kai Sun,Kevin W Huggins et al.
Mehrnaz Abbasi et al.
Obesity and diabetes are chronic metabolic diseases affecting millions worldwide. Current treatments, including lifestyle changes, medications, and surgery, face challenges like poor adherence and side effects. Glucagon-like peptide-1 recep...