The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation [0.03%]
F-box基因家族成员FBXO44通过泛素化降解调节PXR蛋白水平的新机制研究
Rebecca R Florke Gee,Andrew D Huber,Jing Wu et al.
Rebecca R Florke Gee et al.
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-charact...
Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study [0.03%]
阿兹夫定可降低新冠肺炎患者的住院死亡风险：一项基于回顾性队列的研究
Kaican Zong,Hui Zhou,Wen Li et al.
Kaican Zong et al.
In our retrospective cohort study, we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients. It was conducted on the medical records of patients, consecutively admitted for COVID-19 pneumonia to two hospitals in Ch...
Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication [0.03%]
载有miriplatin的脂质体作为一种新型线粒体自噬诱导剂通过抑制POLG和TFAM介导的线粒体DNA复制来抑制胰腺癌增殖
Xiaowei Wang,Mengyan Wang,Meilian Cai et al.
Xiaowei Wang et al.
Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-ca...
Drug discovery by targeting the protein-protein interactions involved in autophagy [0.03%]
通过靶向自噬相关蛋白-蛋白相互作用进行药物发现
Honggang Xiang,Mi Zhou,Yan Li et al.
Honggang Xiang et al.
Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for degradation. Protein-protein interactions (PPIs) play a crucial role at many stages of auto...
Pulmonary endothelium-targeted nanoassembly of indomethacin and superoxide dismutase relieves lung inflammation [0.03%]
依托昔洛酯和超氧化物歧化酶肺内皮靶向纳米制剂缓解肺部炎症
Yi Yang,Makhloufi Zoulikha,Qingqing Xiao et al.
Yi Yang et al.
Lung inflammation is an essential inducer of various diseases and is closely related to pulmonary-endothelium dysfunction. Herein, we propose a pulmonary endothelium-targeted codelivery system of anti-inflammatory indomethacin (IND) and ant...
Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action [0.03%]
利用药用植物Paris polyphylla拆解类固醇皂苷生物合成中的连续糖基化及其抗真菌作用
Yuegui Chen,Qin Yan,Yunheng Ji et al.
Yuegui Chen et al.
Sugar-sugar glycosyltransferases play important roles in constructing complex and bioactive saponins. Here, we characterized a series of UDP-glycosyltransferases responsible for biosynthesizing the branched sugar chain of bioactive steroida...
Xiaodong Zeng,Yuqin Liao,Xue Qiao et al.
Xiaodong Zeng et al.
Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresi...
Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy via excessive autophagy [0.03%]
工程化 CBD 和一氧化碳纳米复合物以过度自噬方式增强癌症治疗
Chang Xiao,Yue Sun,Jialong Fan et al.
Chang Xiao et al.
Although carbon monoxide (CO)-based treatments have demonstrated the high cancer efficacy by promoting mitochondrial damage and core-region penetrating ability, the efficiency was often compromised by protective autophagy (mitophagy). Herei...
A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression [0.03%]
类器官芯片揭示脂联素在促进肝癌进展中的关键作用
Peiliang Shen,Yuanyuan Jia,Weijia Zhou et al.
Peiliang Shen et al.
Hepatic stellate cells (HSCs) represent a significant component of hepatocellular carcinoma (HCC) microenvironments which play a critical role in tumor progression and drug resistance. Tumor-on-a-chip technology has provided a powerful in v...
Erratum: Author correction to "Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles" [Acta Pharmaceutica Sinica B 12 (2022) 1523-1533] [0.03%]
Acta pharmaceutica Sinica B关于“使用ACE2工程化细胞外囊泡中和SARS-CoV-2假病毒”的作者更正 Erratum: Author correction to "Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles" [Acta Pharmaceutica Sinica B 12 (2022) 1523-1533]
Canhao Wu,Qin Xu,Huiyuan Wang et al.
Canhao Wu et al.
[This corrects the article DOI: 10.1016/j.apsb.2021.09.004.]. © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy...
Published Erratum
Acta pharmaceutica Sinica. B. 2023 Nov;13(11):4664-4666. DOI:10.1016/j.apsb.2023.08.007 2023