A review of recent advances in generative artificial intelligence models for biomolecular sciences [0.03%]
生成式人工智能模型在生物分子科学领域近期进展的综述
Jian Jiang,Daixin Li,Guilin Wang et al.
Jian Jiang et al.
Generative artificial intelligence (AI) models, a class of AI techniques that learn data distributions to synthesize novel samples, have emerged as impactful tools across scientific disciplines. In recent years, these models have found exte...
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling [0.03%]
芍药苷通过靶向MEK2调节ERK2-SGK1信号减轻低氧引起的肺损伤
Zhenhui Wu,Yihao Wang,Renjie Wang et al.
Zhenhui Wu et al.
Hypobaric hypoxia-induced lung injury can exacerbate the incidence of plateau pulmonary edema, but relevant pharmacologic measures are relatively limited. Here, we investigate the possible role of paeoniflorin (Pae) in hypobaric hypoxia-ind...
Flavescensines A-L: Novel azaspiro[4.4] heterodimeric alkaloids from Sophora flavescens protect against liver injury by inhibiting DUSP2-mediated mitochondrial apoptosis [0.03%]
飞扬因A-L：防己氨酸抑制DUSP2介导的线粒体凋亡进而保护肝脏的新异类二聚生物碱类成分
Xin Lian,Jianshuang Jiang,Yanan Yang et al.
Xin Lian et al.
By employing a targeted strategy integrating a building blocks-based molecular network (BBMN), network annotation propagation (NAP), ultraviolet spectroscopy (UV), and mass spectrometry (MS), twelve novel spirocyclic heterodimeric alkaloid ...
XiaoJuan Shen,Shijia Yan,Xu Kang et al.
XiaoJuan Shen et al.
Terpenoids exhibit diverse biological activities and thus have a wide range of pharmacological applications. In modern drug discovery, data-driven deep models play a crucial role in facilitating efficient feature representation and knowledg...
Targeting immunosuppressive network in glioblastoma: Emerging strategies to overcome immunodeficiency and enhance therapeutic efficacy [0.03%]
针对胶质母细胞瘤免疫抑制网络的治疗策略：克服免疫缺乏和增强疗效的新方法
Songlei Zhou,Xiaokun Zhang,Jiayi Lin et al.
Songlei Zhou et al.
Glioblastoma (GBM), the most aggressive primary brain tumor, remains a formidable therapeutic challenge, with a median survival under 15 months. Despite the current standard of care-comprising maximal safe surgical resection, radiotherapy, ...
Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccine via increasing transcytosis of antigen and submucosal dendritic cell recruitment [0.03%]
脂质体辛伐他汀通过增加抗原的转胞吞作用和黏膜树突状细胞募集来增强鼻内H1N1流感亚单位疫苗的作用
Afeng Yang,Chen Zhang,Aihua Wu et al.
Afeng Yang et al.
Intranasal vaccines specifically eliciting mucosal immunity in the upper respiratory tract have shown advantages in protecting against respiratory virus invasion. Yet, no clinically licensed intranasal adjuvant remains a major hurdle for th...
Mei Wang,Peng Zhan,Yuning Song
Mei Wang
Membrane-derived biomimetic nanovesicles in anti-tumor immunotherapy: Advances and outlook [0.03%]
基于膜衍生类器官递送系统抗肿瘤免疫治疗研究进展与展望
Xianlu Zhang,Hongwei Jing,Yiyang Wang et al.
Xianlu Zhang et al.
Membrane-derived biomimetic nanovesicles have emerged as a promising platform in cancer immunotherapy due to their intrinsic biocompatibility, functional plasticity, and capability to modulate immune responses. By integrating various immuno...
RDYH58 functionalized exosomes homing muscle fibroblasts for delivery of siRNA targeting FKBP10: A novel therapeutic strategy for idiopathic pulmonary fibrosis [0.03%]
通过RDYH58功能化外泌体靶向肌成纤维细胞递送FKBP10siRNA治疗特发性肺纤维化的新型策略研究
Mengqin Guo,Wenhao Wang,Chuanbin Wu et al.
Mengqin Guo et al.
Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity [0.03%]
基于单细胞RNA测序的放射性治疗引起的食道毒性药物筛选研究
Wenling Tu,Hangfeng Liu,Hongyu Lin et al.
Wenling Tu et al.