Exploring specialized metabolic pathways in medicinal plants with single-cell and spatial omics [0.03%]
利用单细胞和空间组学技术探索药用植物特化代谢途径
Guo Li,Miaomiao Cai,Xinhao Liao et al.
Guo Li et al.
Medicinal plants synthesize an immense diversity of specialized metabolites that play crucial roles in ecological interactions and serve as valuable pharmaceutical resources. However, the biosynthetic pathways responsible for this chemical ...
Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression [0.03%]
新化合物或idonin通过依赖于H3K4me3的SASP抑制来缓解克隆造血诱导的心脏衰老的作用及机制研究
Xingling Chen,Qiangqiang Zhao,Linhuang Chen et al.
Xingling Chen et al.
TET2-mediated clonal hematopoiesis of indeterminate potential (CHIP) is a known cardiovascular risk factor, but its role in cardiac aging and potential for pharmacological intervention remain unclear. Herein, Mendelian randomization using l...
CD74 deficiency protects against doxorubicin cardiotoxicity through RRM2-mediated regulation of ferroptosis [0.03%]
CD74缺乏通过RRM2介导的铁死亡调节保护心脏免受多柔比星损伤
Miyesaier Abudureyimu,Guizhen Wang,Xing Qin et al.
Miyesaier Abudureyimu et al.
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major health threat that limits its clinical application. While mitochondrial dysfunction, oxidative stress and ferroptosis are implicated in DIC pathology, the precise mechanism remains e...
Interactions between the gut microbiome and ferroptosis in degenerative diseases: Novel mechanisms and potential therapeutic strategies [0.03%]
肠道微生物组与铁死亡在退行性疾病中的相互作用：新型机制和潜在治疗策略
Yue Chen,Xiang Wei,Xin Yi et al.
Yue Chen et al.
Degenerative diseases are a group of medical conditions characterized by the progressive and irreversible deterioration of cells, tissues, and organs over time. Emerging evidence highlights the alteration and functions of the gut microbiome...
Qianwen Mu,Qihang Huang,Haolan Deng et al.
Qianwen Mu et al.
The combination of cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway modulation with nanotechnology offers a promising strategy for the development of more effective and less toxic therapies. This revie...
A novel entry inhibitor targeting the stalk domain of the hemagglutinin of H1N1 [0.03%]
一种针对H1N1血凝素茎部结构的新型进入抑制剂
Ying Gong,Tongyu Bi,Fuling Xiao et al.
Ying Gong et al.
Influenza is a global health issue. Vaccines can protect humans from infection from influenza virus. When no suitable vaccine is available, anti-influenza drugs are the first treatment choice. Emergence of drug resistance necessitates devel...
Trojan horse-inspired smart single-atom nanozyme delivery system for synergistic therapy of inflammatory bowel disease [0.03%]
类马达蛋白受体的智能单原子纳米酶递送系统用于炎症性肠病治疗
Tianliang Li,Zhijie Wang,Xin Chang et al.
Tianliang Li et al.
Systemic administration for the clinical management of inflammatory bowel disease (IBD) often leads to various side effects and toxicities, primarily due to broad therapeutic exposure of non-target tissues. Herein, a smart single-atom nanoz...
Identification of boholamide A analogue as a potential hypoxia-selective anti-triple-negative breast cancer agent by targeting eEF1A1 [0.03%]
一种新的博霍赖胺A类似物通过靶向eEF1A1选择性杀伤三阴乳腺癌细胞系及球体的鉴定研究
Guangju Liu,Fengyuan Zhang,Fangzhi Han et al.
Guangju Liu et al.
Triple-negative breast cancer (TNBC) is one of the most aggressive and metastatic forms of breast cancer, for which there are currently no satisfactory therapeutic agents. Here, we reported for the first time that boholamide A, a naturally ...
Sonic priming and biomimetic synergy: A paradigm shift in solid tumor therapy [0.03%]
声学启动和仿生协同作用：实体肿瘤治疗的范式转变
Lay Hong Chuah,Paul Chi-Lui Ho
Lay Hong Chuah
DeepICER: A deep learning framework for predicting compound-induced gene expression profiles [0.03%]
基于深度学习的化合物诱导基因表达谱预测框架
Fanbo Meng,Can Wang,Yue Lin et al.
Fanbo Meng et al.
Accurate prediction of drug-induced gene expression profiles is crucial for phenotype-based drug discovery. Although computational methods have shown potential, they struggle with the complexities of varying doses and durations. To overcome...