Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases [0.03%]
二硫连:一种正在临床前和临床研究中重新定位的用于治疗传染病的药物
Marco M Custodio,Jennifer Sparks,Timothy E Long
Marco M Custodio
This article reviews preclinical and clinical studies on the repurposed use of disulfiram (Antabuse) as an antimicrobial agent. Preclinical research covered on the alcohol sobriety aid includes uses as an anti-MRSA agent, a carbapenamase in...
Modeling and Statistical Optimization of Culture Conditions for Improvement of Antifungal Compounds Production by Streptomyces albidoflavus S19 Strain of Wastewater Origin [0.03%]
废水菌株链霉菌白色黄斑变体S19抗真菌化合物产生的培养条件及统计优化模型研究
S Souagui,W Djoudi,H Boudries et al.
S Souagui et al.
Background: The actinomycetes strains isolated from unexplored ecosystems are a promising alternative for the biosynthesis of novel antimicrobial compounds. Depending on the interesting antifungal activity of the studied ...
Novel Diazenyl Containing Phenyl Styryl Ketone Derivatives as Antimicrobial Agents [0.03%]
一种新型茋类茋酮衍生物抗菌剂
L Sivasankerreddy,B Nagamani,T Rajkumar et al.
L Sivasankerreddy et al.
Background: Antibiotics play an important role in the treatment of infections to the hu-mans and at the same time, irrational, frequent prescription of higher antibiotics, change in gene com-position of microorganisms are...
Stephanie Ferreira,Ruben Fernandes,Monica C Botelho
Stephanie Ferreira
Background: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. Th...
Sulfonamides as Inhibitors of Leishmania - Potential New Treatments for Leishmaniasis [0.03%]
硫胺类利什曼病抑制剂——新的治疗利什曼病的潜在药物
Jade Katinas,Rachel Epplin,Christopher Hamaker et al.
Jade Katinas et al.
Introduction: Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability and drug resistance as the occurrence of leishmaniasis c...
Better Antiretroviral Central Nervous System Penetration is Not Associated with Reduced Chronic Pain in People Living with Human Immunodeficiency Virus [0.03%]
更佳的抗逆转录病毒中枢神经系统渗透与人类免疫缺陷病毒感染人群的慢性疼痛降低无关
Nathaniel M Robbins,Kanokporn Chaiklang,Khuanchai Supparatpinyo
Nathaniel M Robbins
Objective: To determine if better antiretroviral (ARV) central nervous system (CNS) penetration is associated with reduced rates of chronic pain in people living with HIV (PLWH). ...