CDK12 and CDK13 in oncology: from RNA regulation to therapeutic targeting [0.03%]
CDK12和CDK13在肿瘤学中的作用：从RNA调控到治疗靶向
Julia Dudkiewicz-Garbicz,Paweł K Włodarski
Julia Dudkiewicz-Garbicz
This review aims to synthesize current knowledge on Cyclin-dependent kinase 12 (CDK12) and Cyclin-dependent kinase 13 (CDK13), two transcriptional kinases with distinct and overlapping roles in gene regulation, genome stability, and cancer ...
SERPINA1 drives TACE resistance in hepatocellular carcinoma by competitively binding ITGB3 to block ITCH-mediated ubiquitination and degradation [0.03%]
分泌型蛋白A家族成员1通过竞争性结合整合素β3抑制ITCH介导的泛素化降解从而驱动肝癌细胞对TACE治疗产生耐药性
Liou Zhang,Xiaoxi Bai,Mingyang Du et al.
Liou Zhang et al.
Purpose: Transarterial chemoembolization (TACE) is the first-line treatment for intermediate-to-advanced hepatocellular carcinoma (HCC), but post-TACE resistance remains a major clinical challenge. While SERPINA1, a serin...
Ferroptosis in hematological malignancies: molecular mechanisms and therapeutic potential [0.03%]
铁死亡在血液系统恶性肿瘤中的分子机制及治疗潜力
Jiaxi Liu,Rui Liu,Jiyu Miao et al.
Jiaxi Liu et al.
Ferroptosis, an iron-dependent form of regulated cell death characterized by overwhelming accumulation of lipid peroxidation, has emerged as a prominent area of interest in cancer research. Its underlying mechanisms are complex, and the hig...
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells [0.03%]
TRIM47通过稳定PLK1促进肝癌细胞增殖
Tao Xie,Xiaoqi Fan,Tian Yu et al.
Tao Xie et al.
Background: Liver cancer (LC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic options for advanced-stage disease. While tripartite motif-containing 47 (TRIM47), a typical E3 ubiquit...
Unraveling the impact of cancer-associated fibroblasts on lymphatic metastasis of head and neck squamous cell carcinoma [0.03%]
解析癌症相关成纤维细胞对头颈鳞状细胞癌淋巴转移的影响
Zunxuan Xie,Boyang Gao,Han Wu et al.
Zunxuan Xie et al.
Head and neck squamous cell carcinoma (HNSCC) is characterized by a high incidence of lymphatic metastasis and poor clinical prognosis. Cancer-associated fibroblasts (CAFs), as major component of the tumor stroma, play pivotal roles in shap...
Decitabine promotes degradation of DNMT1 and EZH2 via the ubiquitination pathway and inhibits colorectal cancer progression [0.03%]
地西他滨通过促进DNA甲基转移酶1和组蛋白甲基转移酶EZH2的泛素化降解抑制结直肠癌进展
Xiao-Mei Peng,Xin-Peng Shi,Han Chen et al.
Xiao-Mei Peng et al.
Purpose: This study aimed to investigate the role of DNMT1 in CRC progression and its regulatory relationship with TRAF6 and EZH2. Methods: ...
Organoid-based drug screening identifies homoharringtonine as a therapeutic agent for anaplastic thyroid cancer via TFEB-mediated lysosomal dysfunction [0.03%]
基于类器官的药物筛选鉴定出鬼臼毒素homoharringtonine可作为通过TFEB介导的溶酶体功能障碍治疗甲状腺癌的药物
Xinyue Zhang,Zhihui Li,Jiaye Liu et al.
Xinyue Zhang et al.
Purpose: Anaplastic thyroid cancer (ATC) is a rare but aggressive malignancy with unmet clinical needs for novel therapeutic agents. Most prior studies have relied on limited ATC cell lines, which fail to recapitulate tum...
Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma [0.03%]
单细胞和空间转录组测序揭示了高级别IDH突变型胶质瘤中一个独特的亚群的特征
Wei Chen,Min Zheng,Jia-Yin An et al.
Wei Chen et al.
Introduction: (Isocitrate dehydrogenase) IDH-mutant astrocytoma is classified as World Health Organization (WHO) grade 2-4 and is second only to IDH wild-type glioblastoma in the incidence of adult glioma. However, few st...
The oncogenic potential of YAP requires Y357 phosphorylation in cholangiocytes but not in hepatocytes [0.03%]
YAP的致癌潜能不需要肝细胞但需要胆管上皮细胞中的Y357磷酸化
Muhammed Dogukan Aksu,Jayla T Millender,Chantal E McCabe et al.
Muhammed Dogukan Aksu et al.
Purpose: The transcriptional cofactor yes-associated protein (YAP) is activated in primary liver cancers (PLCs). YAP is canonically inhibited through serine 127 (S127) phosphorylation via the Hippo pathway but activated b...
PARP7 and aryl hydrocarbon receptor differentially regulate mammary cancer cell proliferation and STING-induced type I interferon signalling [0.03%]
PARP7和芳香烃受体通过不同的机制调节乳腺癌细胞增殖及STING诱导的一型干扰素信号通路
Ninni E Olafsen,Samaneh S Åhrling,Marit Rasmussen et al.
Ninni E Olafsen et al.
Purpose: PARP7 is a negative regulator of type I interferon (IFN-I) and aryl hydrocarbon receptor (AHR) signalling and has important roles in cell proliferation and antitumor immunity. Recently, several cancer cell lines ...