Lactate and lactylation: metabolic architects of tumor progression and metastasis [0.03%]
乳酸和乳酸化：肿瘤发生和转移的代谢建筑师
Hanyue Ma,Zhuo Gu,Zhenxin Wang
Hanyue Ma
Lactate and its associated modification, lactylation, have emerged as key regulators in influencing various cellular processes. This review explores the multifaceted roles of lactate and lactylation, highlighting their involvement in metabo...
ADAMDEC1-driven CCL2-CCR2-PD-1 axis in esophageal squamous cell carcinoma: a dual threat of O-GlcNAcylation and m6A methylation in neoadjuvant therapy resistance and immune evasion [0.03%]
食管鳞状细胞癌中的ADAMDEC1驱动的CCL2-CCR2-PD-1轴：新辅助治疗耐药和免疫逃逸中O-GlcNAc酰化和m6A甲基化的双重威胁
Jiwei Cheng,Haibo Ma,Xin Qian et al.
Jiwei Cheng et al.
Objective: Esophageal squamous cell carcinoma (ESCA) constitutes a major global health burden, with immune evasion and therapeutic resistance posing significant challenges. This study aims to elucidate the molecular mecha...
A CREM-ITGA2B-MAPK axis drives proliferation and invasiveness in gastric cancer: insights from single-cell analysis [0.03%]
胃癌中的CREM-ITGA2B-MAPK轴驱动增殖和侵袭：单细胞分析的新见解
Hongmei Wu,Mengnan Ye,Lisheng Zheng et al.
Hongmei Wu et al.
Background: Gastric cancer (GC) characterized by profound cellular heterogeneity, with the diversity and interactions of cells within the tumor microenvironment (TME) playing critical roles in tumorigenesis, metastasis, a...
Transcriptional repression of TGFB2-AS1 by GATA6 drives triple-negative breast cancer metastasis [0.03%]
GATA6通过转录抑制TGFB2-AS1促进三阴性乳腺癌转移
Chang Liu,Qianru Yu,Difei Wang et al.
Chang Liu et al.
Purpose: High recurrence rates, significant metastatic potential, and limited overall survival make triple-negative breast cancer (TNBC) the most challenging subtype among breast cancers. Previous studies have indicated t...
TBC1D23 drives lymphatic metastasis in pancreatic ductal adenocarcinoma by altering EGFR cell surface dynamics and signaling [0.03%]
TBC1D23通过改变EGFR细胞表面动力学和信号传导促进胰腺导管腺癌的淋巴转移
Ying-Jui Chao,Hao-Chen Wang,Yu-Lun Chen et al.
Ying-Jui Chao et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating malignancies worldwide, characterized by late diagnosis, rapid progression, and dismal survival rates. The discovery of reliable biomarkers...
The histone acylation network: emerging therapeutic targets for remodeling the epigenetic landscape in pancreatic ductal adenocarcinoma [0.03%]
组蛋白酰基化网络：重塑胰腺导管腺癌表观遗传谱的新兴治疗靶标
Deju Anna Kong,Huang Wang,Mingzhen Wang et al.
Deju Anna Kong et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, a status primarily attributable to its intricate molecular circuitry. The histone acylation network serves as a key orchestrator of PDAC progression throug...
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35 [0.03%]
靶向唾液酸代谢：WZ35驱动的胃癌治疗策略
Boxiang Hong,Ying Wang,Xinran Feng et al.
Boxiang Hong et al.
Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the energy derived from glucose metabolism and the cellular proteins by its intermediate products influence gastric cancer d...
Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer [0.03%]
靶向衰老样肿瘤相关巨噬细胞可提高三阴性乳腺癌的化疗敏感性
Hongxu Zhou,Chengzhao Xu,Jiabeini Zhang et al.
Hongxu Zhou et al.
Purpose: Triple-negative breast cancer (TNBC) frequently develops chemoresistance through poorly understood stromal interactions. This study aimed to elucidate the mediating role of chemotherapy-induced senescence-like tu...
CX3CL1-CX3CR1 signaling orchestrates malignant progression of prostate cancer through luminal progenitor-macrophage crosstalk [0.03%]
CX3CL1-CX3CR1信号通过腔祖细胞-巨噬细胞相互作用调控前列腺癌恶性进展
Yu Jiang,Yuchen Guo,Lizhuang Han et al.
Yu Jiang et al.
Purpose: Progression to castration-resistant prostate cancer (CRPC) is shaped by dynamic interactions within the tumor microenvironment (TME). However, the specific cellular crosstalk driving therapeutic resistance and me...
A habitat radiomics model based on contrast-enhanced MRI for predicting early treatment response to hepatic arterial infusion chemotherapy in patients with unresectable hepatocellular carcinoma [0.03%]
基于强化MRI的肝癌不可切除肝细胞癌患者动脉介入化疗早期治疗反应预测的栖息地影像组学模型
Guanhui Li,Xuefei Zhao,Jie Long et al.
Guanhui Li et al.
Purpose: To develop a contrast-enhanced Magnetic Resonance Imaging (CEMRI)-based habitat radiomics model for predicting early treatment response to hepatic artery infusion chemotherapy with fluorouracil, leucovorin, and o...