The MIF-CD74 axis drives colorectal cancer via glycolytic reprogramming and is targeted by a novel small-molecule inhibitor [0.03%]
Jinwei Lou,Yuhan Chen,Yue Li et al.
Jinwei Lou et al.
Background: Macrophage migration inhibitory factor (MIF) promotes inflammation, regulates immune responses and chemotherapy resistance in the tumor microenvironment. However, its mechanism of action in colorectal cancer (...
EBF3 suppresses lung adenocarcinoma progression and immune evasion via transcriptional repression of CCL24 [0.03%]
Lan Li,YiRan Yang,Dan Li et al.
Lan Li et al.
Purpose: The transcription factor EBF3 is frequently downregulated in lung adenocarcinoma (LUAD), and its low expression is associated with poor patient prognosis. The functional significance and mechanistic basis of EBF3...
Xiaodong Wang,Di Xiong,Songli Cui et al.
Xiaodong Wang et al.
Lactate is no longer viewed as a passive end-product of the Warburg effect; instead, it plays an active role in shaping tumor biology and immune responses. In solid tumors, enhanced glycolysis and lactate export, along with proton handling,...
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer [0.03%]
Xuchu Jin,Yu Liu,Xinyu Zheng et al.
Xuchu Jin et al.
Objective: Breast cancer continues to be a major contributor to cancer-associated deaths among the female population globally. This study aims to investigate the functional role, underlying mechanisms, and clinical releva...
Liquid biopsy in the clinical management of tumor of urinary system: current status and future developments [0.03%]
Runsen Xu,Yiming Zhao,Peng Su et al.
Runsen Xu et al.
Urinary system tumors are a major threat to human health. However, there is a lack of reliable non-invasive examinations for urinary system tumors. Liquid biopsy is an emerging method for detecting biomarkers in patients in recent years. It...
Defu Li,Hui Wang,Zhengping Yu et al.
Defu Li et al.
Purpose: Metastasis underlies most colorectal cancer (CRC)-related deaths, yet its molecular drivers remain incompletely characterized. This study aims to provide novel insights into the mechanisms underlying CRC metastas...
METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway [0.03%]
Sha Li,Xiangyin Chi,Xiaoxue Li et al.
Sha Li et al.
Background: Colorectal cancer (CRC) incidence and mortality rates are steadily on the rise, which brings significant public health concern worldwide, especially in China. Methyltransferase-like 7 A (METTL7A), a member of ...
Stiffness-related stress granules promote the metastasis of early-stage oral squamous cell carcinoma via anoikis resistance [0.03%]
Hong Jiang,Kan Li,Yahui Wang et al.
Hong Jiang et al.
Background: Surgery is the first choice of treatment for oral squamous cell carcinoma (OSCC), including primary tumor resection and neck dissection. However, neck dissection of early-stage OSCC patients is still controver...
Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy [0.03%]
下一代新抗原mRNA疫苗：精准肿瘤免疫治疗的免疫工程技术策略
Xiaoping Li,Parham Jabbarzadeh Kaboli,Ghazaal Roozitalab et al.
Xiaoping Li et al.
Neoantigen mRNA vaccines have progressed from experimental constructs to clinically evaluated immunotherapies grounded in tumor genomics and modular RNA engineering. By encoding tumor-restricted antigens, these platforms aim to induce targe...
Role of DDX39A in modulating the tumor progression and radiosensitivity in esophageal squamous cell carcinoma [0.03%]
DDX39A在食管鳞癌肿瘤进展和放疗敏感性中的作用
Beina Hui,Weibin Hu,Xin Chen et al.
Beina Hui et al.
Purpose: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited treatment options. Although radiotherapy remains a cornerstone of curative treatment, intrinsic and acquired radioresistance freq...