The O-GlcNAc modification of PRRC2C at S2238 promotes SG formation and nasopharyngeal carcinoma metastasis [0.03%]
PRRC2C 糖基化修饰促进小细胞低分化鼻咽癌转移及相关分子机制研究
Haimeng Yin,Shumei Ding,Han Deng et al.
Haimeng Yin et al.
Purpose: Metastasis remains the leading cause of mortality in patients with nasopharyngeal carcinoma (NPC), yet its precise mechanism has not been fully elucidated. ...
Microchromosome maintenance protein 2 is essential in immune infiltration-correlated prognosis of multiple myeloma patients by regulating cell cycle [0.03%]
微染色体维持蛋白2通过调节细胞周期关联免疫浸润影响多发性骨髓瘤患者的预后且必不可少
Aziguli Maihemaiti,Lu Tang,Hui Zhou et al.
Aziguli Maihemaiti et al.
Purpose: Multiple myeloma (MM) is a common hematological malignancy, while the prognostic value of tumor-infiltrating immune cells in MM remains elusive. This study aimed to construct an immune-related prognostic model an...
Structural architecture of collagen and collagen-fibronectin networks is associated with the invasive behavior of liver cancer cells [0.03%]
胶原蛋白和胶原蛋白-纤连蛋白网络的结构架构与肝癌细胞侵袭行为相关
Alexander Hayn,Madlen Matz-Soja,Thomas Berg et al.
Alexander Hayn et al.
Purpose: The remodeling of the extracellular matrix (ECM) is a key feature of tumor development in the liver, particularly in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Fibrosis and cirrhos...
Onco-neurology: a clinical perspective on cancer-associated neurological complications [0.03%]
肿瘤神经病学：关于癌症相关神经系统并发症的临床视角
Yaying Song,Wenbin Wan,Ying Zhang et al.
Yaying Song et al.
Advances in cancer screening and treatment have improved survival, while neurological complications in patients with cancer are gaining clinical relevance. Many of these complications are not attributable to direct tumor invasion, compressi...
Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells [0.03%]
人恶性胸膜间皮瘤细胞中蛋白磷酸酶2磷酸酶活化剂(PPTA)促进癌基因诱导的衰老和卡铂反应
Eleonora Nigliato,Yan Ma,Rita Derua et al.
Eleonora Nigliato et al.
Purpose: Malignant pleural mesothelioma (MPM) is a rare cancer of the pleura, frequently related to asbestos exposure. It is characterized by a grim prognosis, as few therapeutic options are available. Typically, MPM exhi...
Cis-3-hexen-1-ol suppresses bladder cancer progression by inducing mitophagy via the PCK2/AMPK/mTOR signaling pathway [0.03%]
反式-3-己烯-1-醇通过PCK2/AMPK/mTOR信号通路诱导线粒体自噬从而抑制膀胱癌进展
Jingxuan Peng,Quan Zhu,Sha Li et al.
Jingxuan Peng et al.
Background: Cis-3-hexen-1-ol is a naturally occurring green leaf volatile widely distributed in aromatic and medicinal plants. However, its antitumor activity and underlying mechanisms in bladder cancer (BLCA) remain larg...
P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer [0.03%]
以P2RY6+肿瘤相关巨噬细胞为治疗靶点：抑制三阴性乳腺癌的增殖和增强其化疗敏感性
Xin Wang,Mingyue Ma,Mingyu Zhang et al.
Xin Wang et al.
Background: Triple-negative breast cancer (TNBC) harbors an immunosuppressive tumor microenvironment dominated by tumor-associated macrophages (TAMs). P2RY6, a UDP-sensitive purinergic receptor, is implicated in immune mo...
Nutrient stress-induced FTH1 safeguards redox balance and fuels pancreatic ductal adenocarcinoma growth while serving as a therapeutic target and diagnostic biomarker [0.03%]
营养胁迫诱导的FTH1维持红氧平衡并为胰腺导管腺癌生长供能，且可作为治疗靶点和诊断生物标志物
Ziwei Zhang,Xuyang Chen,Jiaqi Wu et al.
Ziwei Zhang et al.
Nutrient-poor tumor microenvironments drive metabolic reprogramming in pancreatic ductal adenocarcinoma (PDAC) cells; however, how iron homeostasis is remodeled under nutrient stress and how this influences tumor fate remains unclear. Here,...
DIO3 associates with sorting nexins and endosomal trafficking networks in ovarian cancer [0.03%]
DIO3与排序衔接蛋白和卵巢癌中的内体转运网络相关联
Daniel Maman-Shinar,Shachar Vanmak,David Bern et al.
Daniel Maman-Shinar et al.
Puropose: Type 3 iodothyronine deiodinase (DIO3) is a membrane-associated enzyme that inactivates thyroid hormones and promotes high-grade serous ovarian cancer (HGSOC) progression. Although DIO3 undergoes continuous recy...
Haiwen Luo,Yingjie Guo
Haiwen Luo
Background: Regulated cell death has long been central to cancer therapy, with apoptosis historically regarded as the principal mechanism underlying treatment efficacy. ...