CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer [0.03%]
CIDEC通过抑制cGMP/PKG通路损害线粒体功能并阻断保护性自噬从而在乳腺癌中发挥肿瘤抑制作用
Xuchu Jin,Yu Liu,Xinyu Zheng et al.
Xuchu Jin et al.
Objective: Breast cancer continues to be a major contributor to cancer-associated deaths among the female population globally. This study aims to investigate the functional role, underlying mechanisms, and clinical releva...
Liquid biopsy in the clinical management of tumor of urinary system: current status and future developments [0.03%]
液体活检在泌尿系统肿瘤临床诊疗中的应用现状及未来展望
Runsen Xu,Yiming Zhao,Peng Su et al.
Runsen Xu et al.
Urinary system tumors are a major threat to human health. However, there is a lack of reliable non-invasive examinations for urinary system tumors. Liquid biopsy is an emerging method for detecting biomarkers in patients in recent years. It...
ASCL2 drives colorectal cancer metastasis through transcriptional activation of TDGF1 [0.03%]
ASCL2通过激活TDGF1转录驱动结直肠癌转移
Defu Li,Hui Wang,Zhengping Yu et al.
Defu Li et al.
Purpose: Metastasis underlies most colorectal cancer (CRC)-related deaths, yet its molecular drivers remain incompletely characterized. This study aims to provide novel insights into the mechanisms underlying CRC metastas...
METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway [0.03%]
METTL7A通过SREBP1/FDFT1/SQLE/CYP51A1/胆固醇代谢通路抑制结直肠癌进展
Sha Li,Xiangyin Chi,Xiaoxue Li et al.
Sha Li et al.
Background: Colorectal cancer (CRC) incidence and mortality rates are steadily on the rise, which brings significant public health concern worldwide, especially in China. Methyltransferase-like 7 A (METTL7A), a member of ...
Stiffness-related stress granules promote the metastasis of early-stage oral squamous cell carcinoma via anoikis resistance [0.03%]
stiffness相关的应激颗粒通过抗凋亡促进早期口腔鳞状细胞癌转移
Hong Jiang,Kan Li,Yahui Wang et al.
Hong Jiang et al.
Background: Surgery is the first choice of treatment for oral squamous cell carcinoma (OSCC), including primary tumor resection and neck dissection. However, neck dissection of early-stage OSCC patients is still controver...
Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy [0.03%]
下一代新抗原mRNA疫苗：精准肿瘤免疫治疗的免疫工程技术策略
Xiaoping Li,Parham Jabbarzadeh Kaboli,Ghazaal Roozitalab et al.
Xiaoping Li et al.
Neoantigen mRNA vaccines have progressed from experimental constructs to clinically evaluated immunotherapies grounded in tumor genomics and modular RNA engineering. By encoding tumor-restricted antigens, these platforms aim to induce targe...
Role of DDX39A in modulating the tumor progression and radiosensitivity in esophageal squamous cell carcinoma [0.03%]
DDX39A在食管鳞癌肿瘤进展和放疗敏感性中的作用
Beina Hui,Weibin Hu,Xin Chen et al.
Beina Hui et al.
Purpose: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited treatment options. Although radiotherapy remains a cornerstone of curative treatment, intrinsic and acquired radioresistance freq...
Integrative analysis and functional validation identified palmitoylated PHGDH as a therapeutic target for colon adenocarcinoma [0.03%]
整合分析与功能验证鉴定棕榈酰化PHGDH为结肠腺癌的治疗靶点
Yixian Song,Lingling Lin,Dejian Liu et al.
Yixian Song et al.
Background: Colon adenocarcinoma (COAD) has high incidence and mortality with poor prognosis, creating an urgent need for novel prognostic models and therapeutic strategies. Protein palmitoylation, an important post-trans...
BCAA catabolism mediates POU2AF1 propionylation to enhance T-ALL development [0.03%]
BCAA分解代谢介导POU2AF1丙酰化以增强T细胞急性淋巴白血病的发展
Sijia Dan,Yilu Xu,Li Xie et al.
Sijia Dan et al.
Purpose: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive, life-threatening hematological malignancy with limited therapeutic regimens. While metabolic reprogramming is known to play critical roles in leukemog...
Bacterial taxa associated with lung cancer cases in Southeast Asians: a pilot case-control study [0.03%]
东南亚人肺癌病例相关的细菌种类：一项病例对照研究
Adrian Low,Yah Ru Juang,Fransiskus X Ivan et al.
Adrian Low et al.
Purpose: Lung cancer is the leading cause of cancer-related mortality worldwide, yet its underlying mechanisms remain unclear. Disruptions in the respiratory microbiome may promote inflammation and carcinogenesis. This st...