Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma [0.03%]
AKT/mTOR信号调控CCNA1介导的鼻咽癌放疗耐受性的作用及机制研究
Ruifang Zeng,Liting Zhong,Pengfei Li et al.
Ruifang Zeng et al.
Background: Nasopharyngeal carcinoma (NPC), as a cancer type highly sensitive to radiotherapy, has radiation therapy as the preferred clinical treatment strategy. However, acquired radioresistance poses a significant chal...
A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC [0.03%]
针对NSCLC患者血脑屏障突破性药物研发：EGFR-MET双特异性抗体与HER3-ADC联合用药克服奥希替尼耐药性研究
Yuanyuan Wang,Haoyue Guo,Ruoshuang Han et al.
Yuanyuan Wang et al.
Purpose: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used as the standard-of-care first-line treatment for EGFR-mutated non-small cell lung cancer (NSCLC) patients. However, EG...
SREBP2-RAB11A-ZDHHC20 axis orchestrates FGFR3 palmitoylation and membrane retention to drive bladder cancer progression [0.03%]
SREBP2-RAB11A-ZDHHC20轴调控FGFR3棕榈酰化和膜锚定以促进膀胱癌进展
Wen-Wen Zhang,Hao-Ran Qu,Xuan-Shuang Du et al.
Wen-Wen Zhang et al.
Clinicopathologic and molecular spectrum of gastrointestinal stromal tumor (GIST) with NTRK fusion and marked response to larotrectinib in GIST with NTRK fusion: a case report [0.03%]
NTRK融合阳性胃肠间质瘤(GIST)的临床病理及分子特点和larotrectinib治疗有效一例报告
Yanying Shen,Qi Peng,Jinxuan Wen et al.
Yanying Shen et al.
Aging reshapes the osteosarcoma ecosystem through immune dysfunction and tumor cell reprogramming [0.03%]
衰老通过免疫功能障碍和肿瘤细胞重编程重塑骨肉瘤生态系统
Rongkai Shen,Meng Chen,Xia Zhu et al.
Rongkai Shen et al.
Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB [0.03%]
低剂量辛伐他汀通过TFEB促进线粒体自噬来保护胰腺癌细胞
Zhiliang Wang,Di Wu,Yue Zhang et al.
Zhiliang Wang et al.
Background: Pancreatic cancer is typically accompanied by fibrosis, forming a dense stromal matrix. This dense matrix restricts drug penetration, making it difficult for drugs to effectively reach tumor cells. Additionall...
A novel molecular classifier enabling identification and prediction on immunotherapeutic response for MYCN-low pediatric neuroblastoma [0.03%]
一种新型分子分类器能够鉴定低MYCN神经母细胞瘤并预测其免疫治疗反应
Liyuan Yang,Jiquan Zhou,Tingyi Fu et al.
Liyuan Yang et al.
Upregulated ARMCX1 suppresses nasopharyngeal carcinoma progression by promoting TRIM21-mediated β-catenin degradation [0.03%]
ARMCX1上调通过促进TRIM21介导的β-catenin降解抑制鼻咽癌进展
Zhe Hu,Enqing Zhuo,Jiankang Guo et al.
Zhe Hu et al.
Background: Armadillo repeat-containing X-linked 1 (ARMCX1) has been reported to exhibit a suppressive effect in a variety of solid tumors. However, neither its biological role nor its potential mechanism of action has ye...
Development of an APC and TP53-based duplex sequencing assay to positively predict colorectal cancer response to anti-EGFR therapy [0.03%]
一种基于APC和TP53的双plex测序测定法，用于正向预测结直肠癌对反义-EGFR疗法的反应的发展
Mingli Yang,Michael J Schell,Jesse J Salk et al.
Mingli Yang et al.
Purpose: EGFR inhibitor (EGFRi) therapies have been FDA-approved for metastatic colorectal cancer (CRC). However, extended RAS/RAF testing required in the drug labels, identifies only non-responders, and only ~50% of sele...
IRF1 suppresses gastric tumorigenesis via dual PI3K/AKT-ERK pathway modulation and functional antagonism of oncogenic MX2 [0.03%]
IRF1通过双重PI3K/AKT-ERK通路调节和致癌蛋白MX2的功能拮抗抑制胃肿瘤发生
Wenjing Chen,Neng Lou,Xietao Chen et al.
Wenjing Chen et al.
Background: Interferon regulatory factor 1 (IRF1) plays a crucial role in the type I interferon (IFN) response. However, its functional role and underlying mechanisms in gastric cancer (GC) remain unclear. This study aims...