Super-enhancer-associated lncRNA HDAC11-AS1 aggravates hepatocellular carcinoma progression by modulating HDAC11 and NUP210 expression via promoting super-enhancer activity [0.03%]
超级增强子相关长链非编码RNA HDAC11-AS1通过促进超级增强子活性调节HDAC11和NUP210的表达从而促进肝细胞癌进展
Weidong Ye,Junyuan Xiao,Jiaxin Li et al.
Weidong Ye et al.
Purpose: Hepatocellular carcinoma (HCC), a malignancy driven by multifaceted genetic and epigenetic mechanisms, is the leading cause of cancer deaths worldwide. Long non-coding RNAs (lncRNAs), particularly super-enhancer-...
Elevated GCN2 levels in cancer cells confer protection from mitotic stress and faster cell movement [0.03%]
癌细胞中升高的GCN2水平可赋予其对抗有丝分裂压力的保护作用并加快细胞运动速度
Vilte Stonyte,Christina Saeten Fjeldbo,Mélanie Langiu et al.
Vilte Stonyte et al.
Purpose: High expression of the stress-response kinase GCN2 has been linked to poor survival in several cancers including cervical cancer, but its underlying biological roles remain incompletely understood. This study aim...
RBM15/IGF2BP2-PTPRH m6A regulatory axis in non-small cell lung cancer [0.03%]
非小细胞肺癌中的RBM15/IGF2BP2-PTPRH m6A调控轴
Keyue Qiu,Xiaoxiao Zheng,Hongxiang Li et al.
Keyue Qiu et al.
Background: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related death globally, highlighting the urgent need for new molecular drivers and therapeutic targets. This study investigates the role of ...
Precision oncology in gastric cancer: navigating molecular subtypes, therapeutic targets, and future horizons [0.03%]
精确肿瘤学在胃癌中的应用：分子亚型、治疗靶点及未来前景导航
Yanyun Hong,Xiaodong Wang,Hang Yu et al.
Yanyun Hong et al.
Gastric cancer (GC) remains a leading cause of cancer-related mortality globally and is characterized by significant inter- and intra-tumoral heterogeneity, which poses major challenges to effective treatment. Although traditional "one-size...
The ubiquitin-like protein FAT10 enhances the autophagy-mediated degradation of ZO-1 by stabilizing ATG3 to promote the lung metastasis of colon cancer [0.03%]
泛素样蛋白质FAT10通过稳定ATG3促进ZO-1的自噬介导降解从而促进结直肠癌肺转移
Zijing Li,Hengqing Zhu,Dongnian Du et al.
Zijing Li et al.
Purpose: The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directs substrates to the 26 S proteasome, but its role in autophagic protein degradation remains unclear. ...
Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis [0.03%]
代谢压力下 Stiripentol 通过干扰饱和脂肪酸/不饱和脂肪酸稳态诱导胰腺癌细胞内质网应激和焦亡
Jie Ding,Jingbing Pan,Wenduo Xue et al.
Jie Ding et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by profound chemoresistance, creating an urgent need for novel therapies to overcome treatment failure. Although stiripentol ...
Pharmacological inhibition of PGK1 suppresses EGFR-positive esophageal squamous cell carcinoma by dual targeting of glycolysis and autophagy-dependent EGFR degradation [0.03%]
药理学抑制PGK1通过双重靶向糖酵解和自噬依赖的EGFR降解来抑制EGFR阳性食管鳞状细胞癌
Juan Ge,Yongfei Chen,Zongru Jiang et al.
Juan Ge et al.
Introduction: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited treatment options. Phosphoglycerate kinase 1 (PGK1), with both glycolytic and kinase activities, has been implicated in tumo...
The MIF-CD74 axis drives colorectal cancer via glycolytic reprogramming and is targeted by a novel small-molecule inhibitor [0.03%]
MIF-CD74轴通过糖酵解重新编程驱动结直肠癌并被一种新型小分子抑制剂靶向
Jinwei Lou,Yuhan Chen,Yue Li et al.
Jinwei Lou et al.
Background: Macrophage migration inhibitory factor (MIF) promotes inflammation, regulates immune responses and chemotherapy resistance in the tumor microenvironment. However, its mechanism of action in colorectal cancer (...
EBF3 suppresses lung adenocarcinoma progression and immune evasion via transcriptional repression of CCL24 [0.03%]
EBF3通过转录抑制CCL24抑制肺腺癌进展和免疫逃逸
Lan Li,YiRan Yang,Dan Li et al.
Lan Li et al.
Purpose: The transcription factor EBF3 is frequently downregulated in lung adenocarcinoma (LUAD), and its low expression is associated with poor patient prognosis. The functional significance and mechanistic basis of EBF3...
Lactate signaling and immune suppression in tumors: mechanisms and therapeutic implications [0.03%]
乳酸在肿瘤免疫抑制中的信号传导机制及其治疗意义
Xiaodong Wang,Di Xiong,Songli Cui et al.
Xiaodong Wang et al.
Lactate is no longer viewed as a passive end-product of the Warburg effect; instead, it plays an active role in shaping tumor biology and immune responses. In solid tumors, enhanced glycolysis and lactate export, along with proton handling,...