Molecular classification identifies aggressive gastrointestinal stromal tumor subtype targetable by PARP inhibitors [0.03%]
分子分类确定出可被PARP抑制剂靶向的具侵袭性的胃肠道间质瘤亚型
Yuqi Ding,Xiaoxue Ren,Ye Yang et al.
Yuqi Ding et al.
Purpose: Gastrointestinal stromal tumors (GISTs), the most common gastrointestinal sarcomas, experience a high rate of resistance to standard treatment tyrosine kinase inhibitor (TKI) imatinib, leading to tumor progressio...
Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma [0.03%]
急性胰腺炎和胰导管腺癌中的腺泡-导管化生现象
Xiangyu Zhang,Yutong Zhao,Cheng Qin et al.
Xiangyu Zhang et al.
Acinar-ductal metaplasia (ADM) represents a dynamic and reversible cellular adaptation in the pancreas, whereby acinar cells dedifferentiate and transdifferentiate into duct-like cells in response to inflammatory, metabolic, and environment...
RRM1 competes with NEDD4 to stabilize USP19 by blocking K387 ubiquitination and suppresses autophagy-mediated chemoresistance in colorectal cancer [0.03%]
RRM1通过与NEDD4竞争使USP19稳定并抑制K387泛素化而抑制自噬介导的结直肠癌化疗耐药性
Lingxiao Wang,Weixing Zhang,Yifan Kang et al.
Lingxiao Wang et al.
Background: Resistance to 5-fluorouracil (5-FU) remains a major clinical challenge in colorectal cancer (CRC) treatment. This study investigates the non-canonical role of ribonucleotide reductase subunit M1 (RRM1) in regu...
ITGB5 promotes immune escape in hepatocellular carcinoma by regulating PD-L1 through SETDB1/Hippo signaling pathway [0.03%]
ITGB5通过SETDB1/Hippo信号通路调节PD-L1促进肝癌免疫逃逸
Mengmeng Wang,Li Gu,Ruijiang Zeng et al.
Mengmeng Wang et al.
Background: The overall response rate to immune checkpoint inhibitors (ICIs) in HCC patients remains low. It has been reported that ITGB5 correlate with the immune infiltration of tumors. Our previous study showed that IT...
Reverse cardio-oncology: neuroendocrine axis activation and cardiovascular-disease-derived factors synergistically remodel the tumor microenvironment [0.03%]
逆向心身肿瘤学：神经内分泌轴活化和心血管疾病衍生因子协同重塑肿瘤微环境
Siyu Ji,Nan Zhang,Xin Hu
Siyu Ji
Cardiovascular disease and cancer are increasingly recognized as biologically interconnected conditions with a bidirectional relationship. In addition to the well-established cardiotoxic effects of cancer therapies, accumulating epidemiolog...
Exosomal LINC00323 accelerates angiogenesis through activating the MAPK and JAK-STAT pathways by stabilizing CDC5L in NSCLC [0.03%]
非小细胞肺癌中环状RNA LINC00323通过稳定CDC5L来激活MAPK和JAK-STAT途径促进血管生成
Bin Ke,Hai Zhong,Xiaofei Chen et al.
Bin Ke et al.
Background: Non-small cell lung cancer (NSCLC) stands as a predominant contributor to cancer-related mortality, with angiogenesis serving a pivotal role in the advancement of the disease. The upregulation of LINC00323 in ...
Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer [0.03%]
低硫酯相关特征鉴定出介导胃癌免疫抑制的SPARC+/CYR61+间质细胞
Yuxuan Xu,Xianming Kong,Jin Li et al.
Yuxuan Xu et al.
Background: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain largely undefined. ...
Tumor lymph node metastasis chip reveals that the NECTIN3-TIGIT axis promotes melanoma metastasis by enhancing treg cell function and inducing CD8+ T cell exhaustion [0.03%]
肿瘤淋巴结转移芯片揭示NECTIN3-TIGIT轴通过增强调节性T细胞功能和诱导CD8+t细胞衰竭来促进黑色素瘤转移
Cuihao Song,Wenwei Zhu,Yaolin Li et al.
Cuihao Song et al.
Purpose: To investigate the role and molecular mechanism of the NECTIN3-TIGIT axis in melanoma lymph node metastasis. Methods: Single-c...
Tasimelteon inhibits glioma proliferation by inducing ferroptosis via the SP1/ACSL4 pathway [0.03%]
塔西莫德通过SP1/ACSL4途径诱导铁死亡从而抑制胶质瘤增殖
Yi Chen,Jicheng Li,Huilan Yang et al.
Yi Chen et al.
Purpose: Gliomas are aggressive tumors with poor treatment outcomes. Tasimelteon, an FDA-approved melatonin receptor agonist with favorable blood-brain barrier penetration, has unexplored anti-tumor potential. This study ...
The O-GlcNAc modification of PRRC2C at S2238 promotes SG formation and nasopharyngeal carcinoma metastasis [0.03%]
PRRC2C 糖基化修饰促进小细胞低分化鼻咽癌转移及相关分子机制研究
Haimeng Yin,Shumei Ding,Han Deng et al.
Haimeng Yin et al.
Purpose: Metastasis remains the leading cause of mortality in patients with nasopharyngeal carcinoma (NPC), yet its precise mechanism has not been fully elucidated. ...