RNF149/RBM25/MYC/PD-L1 axis promotes CD8+ T cell dysfunction in microenvironment of clear cell renal cell carcinoma [0.03%]
RNF149/RBM25/MYC/PD-L1轴促进透明细胞肾细胞癌微环境中CD8⁺T细胞功能障碍
Xuefei Liu,Xingming Qu,Yuanhua Zou et al.
Xuefei Liu et al.
Background: Renal cell carcinoma (RCC) is a common kidney cancer, and clear cell RCC (ccRCC) represents the most common pathological type. CD8+ T cells are the most primary killing cells in tumor microenvironment (TME). R...
Lactylation shields S100A11 from degradation to promote gastric cancer metastasis [0.03%]
乳酰化保护S100A11免受降解以促进胃癌转移
Qingrui Zhang,Yuhang Zhou,Fangning Wang et al.
Qingrui Zhang et al.
Background: Protein lactylation, a novel post-translational modification utilizing lactate as the substrate, has emerged as a key mechanism linking metabolic alterations to cancer progression. This study aims to investiga...
PDIA6 exacerbates hepatocellular carcinoma via enhancing proteasome-dependent degradation of AKAP12 [0.03%]
PDIA6通过增强AKAP12的蛋白酶体依赖性降解来促进肝细胞癌恶化
Rucheng Yao,Yuhan Yin,Xiaosong Li et al.
Rucheng Yao et al.
The continuously rising incidence and persistently high mortality of hepatocellular carcinoma (HCC) have created an urgent need for a deeper understanding of the molecular mechanisms underlying this disease. In the present study, leveraging...
The malignant synapse: architecture, signal integration, and therapeutic vulnerabilities in glioma [0.03%]
恶性的突触：胶质瘤中的结构、信号转导和治疗弱点
Bo Yuan,Xiaolin Zhang,Dongying Zheng et al.
Bo Yuan et al.
Emerging evidence has fundamentally reshaped the neuro-oncological paradigm, revealing that gliomas and brain metastases are not isolated cellular masses but synaptically integrated entities within the brain's neural circuitry. This review ...
Hypoxia-induced exosomal LNCOC1 orchestrates bladder cancer progression via the YBX1/PIK3CA axis and serves as a potential liquid biopsy biomarker [0.03%]
缺氧诱导的LNCOC1外泌体通过YBX1/PIK3CA轴促进膀胱癌进展并作为潜在的液体活检生物标志物
Haoxiang Xu,Chenglin Yang,Qiangfeng Fu et al.
Haoxiang Xu et al.
Bladder cancer (BCa) is a prevalent genitourinary malignancy characterized by limited specific diagnostic and therapeutic options. Although hypoxia is known to drive tumor progression via exosome-mediated communication, the specific oncogen...
CHIP/STUB1 suppresses colorectal tumorigenesis through ubiquitin-mediated degradation of LDHA and inhibition of glycolysis [0.03%]
CHIP/STUB1通过泛素介导的LDHA降解和抑制糖酵解来抑制结直肠肿瘤发生
Chunya Li,Yanshen Kuang,Xinwen Hou et al.
Chunya Li et al.
Background: The E3 ubiquitin ligase CHIP/STUB1 is a known tumor suppressor in colorectal cancer (CRC) and other malignancies, but its mechanistic role in metabolic reprogramming remains elusive. This study aimed to elucid...
SGLT2 inhibition induces autophagic flux blockade and sensitizes pancreatic cancer to EGFR-targeted therapy [0.03%]
SGLT2抑制诱导自噬流阻滞并使胰腺癌对EGFR靶向治疗敏感化
Yuxin Wang,Enkui Zhang,Rui Ma et al.
Yuxin Wang et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with profound metabolic rewiring and resistance to therapy. Sodium-glucose cotransporter 2 (SGLT2) regulates glucose uptake, but its role in PDAC ...
Radiation induces an EGFR-dependent lactate-epigenetic program underlying synergy with EGFR inhibition [0.03%]
辐射通过EGFR依赖的乳酸表观遗传程序诱导与EGFR抑制协同作用
Hongxia Cheng,Lu Meng,Shilan Luo et al.
Hongxia Cheng et al.
Purpose: Clinical studies have suggested a therapeutic synergy between EGFR-TKIs and radiotherapy; however, the underlying mechanisms remain incompletely understood, particularly in tumors harboring the acquired resistanc...
Neural regulation of cancer: from synaptic integration to neuro-immune regulation [0.03%]
神经调控癌症：从突触整合到神经免疫调节
Xiaomeng Li,Yuxin Li,Xiaoyan Shi et al.
Xiaomeng Li et al.
The emerging field of cancer neuroscience has reshaped our understanding of tumor biology, showing that the nervous system is an active participant in the tumor microenvironment. It modulates tumor progression through synaptic communication...
Enriched environment inhibits melanoma by reshaping gut microbiota and enriching Parabacteroides distasonis [0.03%]
富集环境通过重塑肠道微生物群和丰富普拉罗伯特菌抑制黑色素瘤
Xin Li,Huimin Li,Qing Wang et al.
Xin Li et al.
Purpose: The role of psychological factors in the holistic regulation of cancer has garnered significant attention. Psychological eustress induced by an enriched environment (EE) inhibits various cancers including melanom...