CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma [0.03%]
糖尿病胰腺癌相关成纤维细胞来源的cxcl12介导适应性免疫异常聚集及功能障碍
Jialun Wang,Yue Zhou,Xiaoxuan Han et al.
Jialun Wang et al.
Background: Diabetes mellitus (DM) affects the occurrence and progression of pancreatic adenocarcinoma (PAAD), but the DM-related immune characteristic in PAAD remains unclear. This study aimed to elucidate the immune lan...
Neural-tumor crosstalk and molecular targeting: mechanisms and therapeutic implications in cancer neuroscience [0.03%]
神经肿瘤相互作用及分子靶向：癌症神经科学中的机制和治疗意义
Tianhui Hou,Huaze Ding,Guofang Huang et al.
Tianhui Hou et al.
The nervous system is increasingly recognized as a key regulator of the tumor microenvironment, engaging in bidirectional crosstalk with cancer cells through neurotransmitters, neuropeptides, and synaptic-like connections. Autonomic nerves ...
Correction to: Unraveling the impact of cancer-associated fibroblasts on lymphatic metastasis of head and neck squamous cell carcinoma [0.03%]
Correction to: 解开癌症相关成纤维细胞对头颈鳞状细胞癌淋巴转移影响的谜团
Zunxuan Xie,Boyang Gao,Han Wu et al.
Zunxuan Xie et al.
Xin Chen,Jing Yang,Yongjun Ma
Xin Chen
Glycolysis is a ubiquitous energy-supply process that occurs in virtually all living cells. The phenomenon of aerobic glycolysis, known as the Warburg effect, is observed and considered as a hallmark of tumorigenesis. However, the roles and...
METTL1-mediated m7G tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation [0.03%]
METTL1介导的tRNA甲基化通过转录后调控促进结直肠癌进展和肝转移
Jiale Chen,Gaomin Zheng,Yixi Wen et al.
Jiale Chen et al.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with colorectal cancer liver metastasis (CRLM) being the primary cause of death. Despite its clinical significance, the molecul...
Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy [0.03%]
肿瘤微环境中的血小板：免疫排斥和抗免疫检查点抑制剂治疗抵抗的潜在介导因素
Atefeh Nasir Kansestani,Mohammad Erfan Zare,Jun Zhang
Atefeh Nasir Kansestani
Cancer cells employ diverse strategies to evade immune surveillance and resist therapy, including immune exclusion—a phenomenon where cytotoxic T cells fail to infiltrate the tumor microenvironment (TME), severely limiting immune checkpoin...
Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma [0.03%]
AKT/mTOR信号调控CCNA1介导的鼻咽癌放疗耐受性的作用及机制研究
Ruifang Zeng,Liting Zhong,Pengfei Li et al.
Ruifang Zeng et al.
Background: Nasopharyngeal carcinoma (NPC), as a cancer type highly sensitive to radiotherapy, has radiation therapy as the preferred clinical treatment strategy. However, acquired radioresistance poses a significant chal...
A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC [0.03%]
针对NSCLC患者血脑屏障突破性药物研发：EGFR-MET双特异性抗体与HER3-ADC联合用药克服奥希替尼耐药性研究
Yuanyuan Wang,Haoyue Guo,Ruoshuang Han et al.
Yuanyuan Wang et al.
Purpose: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used as the standard-of-care first-line treatment for EGFR-mutated non-small cell lung cancer (NSCLC) patients. However, EG...
SREBP2-RAB11A-ZDHHC20 axis orchestrates FGFR3 palmitoylation and membrane retention to drive bladder cancer progression [0.03%]
SREBP2-RAB11A-ZDHHC20轴调控FGFR3棕榈酰化和膜锚定以促进膀胱癌进展
Wen-Wen Zhang,Hao-Ran Qu,Xuan-Shuang Du et al.
Wen-Wen Zhang et al.
Clinicopathologic and molecular spectrum of gastrointestinal stromal tumor (GIST) with NTRK fusion and marked response to larotrectinib in GIST with NTRK fusion: a case report [0.03%]
NTRK融合阳性胃肠间质瘤(GIST)的临床病理及分子特点和larotrectinib治疗有效一例报告
Yanying Shen,Qi Peng,Jinxuan Wen et al.
Yanying Shen et al.