Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient [0.03%]
基于类器官的全程临床导航研究发现罕见肿瘤患者的精准药物机会和优化的浸润淋巴细胞治疗方案：神经内分泌癌患者个例报告
Xinyu Gao,Zhenjiang Liu,Zhaoting Xu et al.
Xinyu Gao et al.
Purpose: Rare cancer patients face dire prognoses due to high malignancy and scarce treatment options, underscoring an imperative for personalized strategies. This study aims to evaluate the potential of precision medicin...
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma [0.03%]
单细胞胆固醇代谢图谱揭示了肝癌治疗的新脆弱性FDPS
Xupeng Yang,Jiajun Li,Yurong Wang et al.
Xupeng Yang et al.
Purpose: Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immunotherapy resistance. This study aimed to delineate the single-cell landscape of cholester...
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma [0.03%]
针对胶质母细胞瘤，MPS1抑制剂NTRC 0066-0体外和体内疗效的差异性研究
Mark C de Gooijer,Daria M Fedorushkova,Ping Zhang et al.
Mark C de Gooijer et al.
Purpose: Glioblastoma (GBM) is the most common adult primary brain tumor for which new therapeutic strategies are desperately needed. Monopolar spindle 1 (MPS1) is a mitotic kinase that plays a pivotal role in the spindle...
Correction to: Intratumoral PD-1high CD8+T cells correlate with AFP levels in HCC patients: a brief report [0.03%]
对：“肝癌患者肿瘤内PD-1高度表达的CD8+t细胞与AFP水平相关：简短报告」的研究的更正
Zuzana Macek Jilkova,Julien Ghelfi,Lucile Dumolard et al.
Zuzana Macek Jilkova et al.
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway [0.03%]
泛癌分析揭示胆固醇吸收是调节肿瘤免疫特征和KRAS通路的因子
Ana Luísa Machado,Ana Pinto,Joana Carvalho et al.
Ana Luísa Machado et al.
Purpose: Cholesterol dysregulation plays a central role in tumor progression and has emerged as a potential therapeutic target. Its dysregulation within the tumor microenvironment is increasingly considered a strong modif...
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour [0.03%]
NAB2-STAT6融合介导的孤立性纤维瘤的致癌机制与组蛋白修饰和 hippo 信号通路激活密切相关
Carmen Salguero-Aranda,Laura Lobo-Selma,Amparo Beltrán-Povea et al.
Carmen Salguero-Aranda et al.
Purpose: Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an aberrant transcriptional regulator whose functions beyond EGR1 activation remain incomplete...
CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma [0.03%]
CSRP2通过PRC1组分调节PDGFRA / PI3K / AKT信号在胶质瘤中的作用
Airexiati Kuerban,Lin Xie,Mingliang He et al.
Airexiati Kuerban et al.
Purpose: Glioblastoma (GBM) is the most common and aggressive primary brain tumor, characterized by poor prognosis and therapeutic resistance. Mesenchymal gliomas, in particular, exhibit more aggressive behavior and worse...
ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses [0.03%]
ENY2转录和出口复合物亚基2缺乏通过NPM1 / MDM2 / p53依赖性和非依赖性反应诱导核仁应激以抑制肿瘤进展
Shiqi Zuo,Siyuan He,Zhiqin Zhu et al.
Shiqi Zuo et al.
Purpose: The selective induction of nucleolar stress in cancer cells has become a potential anticancer therapy. However, precisely regulating the key molecules involved in nucleolar stress remains a challenging topic in c...
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies [0.03%]
解读SR蛋白调控：激酶、磷酸酶及治疗靶向策略
Nasi Liu,Fleur van der Ende,Bob van de Water et al.
Nasi Liu et al.
Intratumoral PD-1high CD8+ T cells correlate with AFP levels in HCC patients: a brief report [0.03%]
肝癌患者中的瘤内PD-1高表达CD8+t细胞与AFP水平相关性：简短报告
Macek Jilkova Zuzana,Ghelfi Julien,Dumolard Lucile et al.
Macek Jilkova Zuzana et al.
Purpose: Hepatocellular carcinoma (HCC), the most common primary liver cancer, typically arises in a context of chronic inflammation driven by metabolic dysfunction, long-term alcohol use, viral hepatitis, and other etiol...