TFAP2A enhances radioresistance of non-small cell lung cancer by transcriptionally activating BRCA1 : TFAP2A promotes NSCLC radioresistance [0.03%]
转录激活BRCA1基因的TFAP2A通过增强非小细胞肺癌患者的放射抵抗性促进肿瘤放疗抗性的形成
Jiachun Ma,Fei Wang,Jingxin Zhang et al.
Jiachun Ma et al.
Introduction: Radioresistance remains a major obstacle in the treatment of non-small cell lung cancer (NSCLC). Transcription factor AP-2α (TFAP2A) has been implicated in tumor progression, but its role in NSCLC radioresi...
Deciphering the regulatory role of ADAM8 in the PDAC tumor microenvironment [0.03%]
解码ADAM8在胰腺癌肿瘤微环境中的调控作用
Kimia Zandieh,Lena Cook,Kai Zhao et al.
Kimia Zandieh et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited therapeutic options, driven in part by its immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) a...
Targeting RPRD1B overcomes chemoresistance in gastric cancer by suppressing the TOPBP1-mediated DNA damage repair pathway [0.03%]
靶向RPRD1B通过抑制TOPBP1介导的DNA损伤修复途径克服胃癌化疗耐药性
Jian Sheng,Jianghua Li,Chenxi Cao et al.
Jian Sheng et al.
Background: Despite the widespread adoption of 5-fluorouracil (5-FU)-based regimens as first-line therapy for gastric cancer, a substantial number of patients develop innate or acquired resistance, highlighting the critic...
From cystogenesis to carcinogenesis in ADPKD: risk modeling and a multistep precision surveillance [0.03%]
从ADPKD的囊肿生成到癌症生成：风险模型和多步精准监测
Angeliki Margoni,Kostas A Papavassiliou,Athanasios G Papavassiliou
Angeliki Margoni
Mitochondrial stress-induced cuproptosis: a metabolic bridge to reprogramming the GBM immune microenvironment [0.03%]
线粒体压力诱导的铜死亡：重塑胶质母细胞瘤免疫微环境的代谢桥梁
Wenyang Li,Yaqing Lv,Guanrong Wang et al.
Wenyang Li et al.
Glioblastoma (GBM) remains the most lethal primary brain malignancy, characterized by profound metabolic heterogeneity and an immunosuppressive tumor immune microenvironment (TIME) that severely limits the efficacy of immune checkpoint bloc...
Integrative machine learning reveals a TLS signature and CCL5-CCR1 axis-associated immune remodeling in breast cancer [0.03%]
集成机器学习揭示了乳腺癌中TLS信号和CCL5-CCR1轴相关的免疫重塑现象
Chuyi Wang,Pengcheng Ding,Wei Ouyang et al.
Chuyi Wang et al.
Background: The transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is a critical but poorly understood step in breast cancer progression. This study characterizes the dynamic remodeling of ...
RNA-binding protein RALYL-mediated BCL11B RNA stability promotes immune escape in small cell lung cancer through transcriptional activation of BUB3 [0.03%]
RNA结合蛋白RALYL介导的BCL11B RNA稳定性通过转录激活BUB3促进小细胞肺癌免疫逃逸
Jiayue Shao,Shuangqing Liu,Ling Qin et al.
Jiayue Shao et al.
Purpose: Small cell lung cancer (SCLC) is marked by rapid tumor growth and poor outcomes and necessitates effective treatments. This paper explores the molecular mechanisms by which BCL11B affects immune escape in SCLC. ...
Inhibition of DLX6 sensitizes lung adenocarcinoma to cisplatin via GPX4-dependent ferroptosis [0.03%]
DLX6抑制通过GPX4依赖性铁死亡增强肺腺癌对顺铂的敏感性
Zedong Sun,Minmin Zhou,Can Wang et al.
Zedong Sun et al.
Background: Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide, with limited treatment options due to inherent chemotherapy resistance. Ferroptosis, an iron-dependent form of regulated cel...
Monomethyl phthalate promotes hepatocellular carcinoma progression through MMP9 upregulation [0.03%]
单甲基邻苯二甲酸通过上调MMP9促进肝癌进展
Tianming Liu,Yong Yang
Tianming Liu
Hepatocellular carcinoma (HCC) is recognized as the third leading cause of cancer-related death worldwide, and its epidemiological features are shifting from viral to non-viral etiologies. Phthalates (PAEs) are widely used plastic additives...
RNF114-PACSIN3 signaling axis promotes hepatocellular carcinoma progression by enhancing GLUT1 membrane retention and glucose uptake [0.03%]
RNF114-PACSIN3信号轴通过增强GLUT1膜驻留和葡萄糖摄取促进肝细胞癌进展
Yue Song,Yilu Lu,Qixiang Liu et al.
Yue Song et al.
Purpose: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with current therapies often limited by significant drug resistance. Owing to the Warburg effect, targeting cancer-specific met...