Recent in vitro advances in the ocular antimicrobial agents against Acanthamoeba [0.03%]
最近针对阿米巴抗菌眼部药物的体外实验进展
Chun-Hsien Chen,Jian-Ming Huang,Yu-Jen Wang et al.
Chun-Hsien Chen et al.
This review examines the advancements in antimicrobial drug discovery with in vitro assays for Acanthamoeba, highlighting the efficacy of current topical antimicrobial agents. In recent decades, the treatment and diagnosis of Acanthamoeba k...
Investigation of risk factors associated with Ancylostoma spp. infection and the benzimidazole F167Y resistance marker polymorphism in dogs from the United States [0.03%]
美国犬钩口线虫属感染及苯并咪唑F167Y抗性标记多态性的风险因素调查研究
Pablo D Jimenez Castro,Jennifer L Willcox,Haresh Rochani et al.
Pablo D Jimenez Castro et al.
Ancylostoma caninum is the most significant intestinal nematode parasite of dogs. We acquired fecal surveillance data from a large population of dogs in the United States (US). A diagnostic test using real-time PCR (qPCR) for Ancylostoma sp...
Culturing of Giardia lamblia under microaerobic conditions can impact metronidazole susceptibility by inducing increased expression of antioxidant enzymes [0.03%]
密闭环境下培养的溶组织内阿米巴对甲硝唑敏感性增加通过诱导抗氧化酶高表达实现
Kateryna Starynets,Ana Paunkov,Anja Wagner et al.
Kateryna Starynets et al.
The microaerophilic/anaerobic protist Giardia lamblia is a world-wide occurring parasite of the human small intestine. It causes giardiasis which manifests as diarrhoea accompanied by other sequelae. Giardiasis is most commonly treated with...
Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women [0.03%]
结合斑马鱼胚胎发育毒性测定（ZEDTA）和血红蛋白染色技术加速新型抗疟药物研究用于孕妇群体中有效性及安全性的评估
Lucia Borrallo-Lopez,Laura Guzman,Noelia G Romero et al.
Lucia Borrallo-Lopez et al.
Background: Malaria during pregnancy implies a high risk for the mother and the developing child. However, the therapeutic options for pregnant women have historically been very limited, especially during the first trimes...
Selective activity of Tabebuia avellanedae against Giardia duodenalis infecting organoid-derived human gastrointestinal epithelia [0.03%]
从类器官衍生的人类胃肠道上皮中选择性筛选Tabebuia avellanedae对抗Giardia duodenalis的作用
Giulia Rigamonti,Fabrizia Veronesi,Elisabetta Chiaradia et al.
Giulia Rigamonti et al.
Giardia duodenalis is a widespread intestinal protozoan that affects mammals, including humans. Symptoms can range from being subclinical to causing severe abdominal pain and diarrhoea. Giardiasis often requires repeated treatment with synt...
Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis [0.03%]
多房棘球绦虫丝氨酸代谢研究：丝氨酸脱氢酶作为泡型棘球蚴病的潜在药物靶标
Marc Kaethner,Pascal Zumstein,Joachim Müller et al.
Marc Kaethner et al.
Alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. We recently showed that E. multilocularis metacestode vesicles scavenge large amounts of L-threonine ...
3'-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine [0.03%]
3'-脱氧链霉素素：治疗锥虫病和梅迪亚病的潜在药物候选物
Kayhan Ilbeigi,Dorien Mabille,Rajdeep Roy et al.
Kayhan Ilbeigi et al.
Surra and Dourine are widespread diseases caused by two protozoan parasites Trypanosoma brucei evansi and Trypanosoma brucei equiperdum, respectively. A wide range of animals including camels, horses, cattle and buffaloes are susceptible to...
Biotransformation of anthelmintics in nematodes in relation to drug resistance [0.03%]
与药物抗性有关的线虫体内驱虫药的生物转化
Ondřej Vosála,Josef Krátký,Petra Matoušková et al.
Ondřej Vosála et al.
In all organisms, the biotransformation of xenobiotics to less toxic and more hydrophilic compounds represents an effective defense strategy. In pathogens, the biotransformation of drugs (used for their elimination from the host) may provid...
Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK [0.03%]
定量DNA metabarcoding揭示了英国一种对大环内酯和吡rantel具有抗性的cyathostomin群体的物种组成
K E Bull,J Hodgkinson,K Allen et al.
K E Bull et al.
Cyathostomins are the most abundant equid endoparasites globally. There are approximately fifty cyathostomin species and, whilst they occupy distinct niches within the large intestine, they are generally considered to share similar characte...
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways [0.03%]
尼特罗西林通过DNA损伤和压力反应途径对卡氏棘阿米巴显示抗阿美巴活性的证据
Lijun Chen,Wei Han,Wenwen Jing et al.
Lijun Chen et al.
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic en...