Metabolomics study of 3-O-p-(Z/E)-coumaroyltormentic acid-treated Trypanosoma brucei brucei [0.03%]
3-O-反式/顺式-香豆酰tormentic酸处理后的布鲁西原虫代谢组学研究
Lúcia Mamede,Fanta Fall,Madeline Vast et al.
Lúcia Mamede et al.
Trypanosomiasis is a parasitic disease for which new treatments are needed due to the frequent occurrence of adverse side effects of current available drugs. Natural compounds found in traditionally used plants offer opportunities to discov...
Jessica L Home,Geoffrey I McFadden,Christopher D Goodman
Jessica L Home
The spread of drug-resistant Plasmodium threatens malaria control efforts. Thus, understanding the mechanisms of resistance is crucial for implementing effective treatments and prevention strategies. The prokaryote-like translational machin...
gdSir2.1 and gdSir2.3 are involved in albendazole resistance in Giardia duodenalis via regulation of the oxidative stress response [0.03%]
gdSir2.1和gdSir2.3通过调节氧化应激反应参与肠道毛滴虫阿苯达唑耐药性产生
Adrián Chávez-Cano,Scott C Dawson,M Guadalupe Ortega-Pierres
Adrián Chávez-Cano
Albendazole resistance in Giardia duodenalis includes a complex and multifactorial challenge that potentially involves non-reported pathways such as the participation of metabolic regulators. In this context, sirtuins, known as metabolic se...
Effect of urea and squaramide IMPDH inhibitors on C. parvum: in vitro trial design impacts the assessment of drug efficacy [0.03%]
尿素和squaramide鸟苷酸环化酶抑制剂对隐孢子虫的影响：体外试验设计影响药物疗效的评估
Anne-Charlotte Lenière,Amit Upadhyay,Jérôme Follet et al.
Anne-Charlotte Lenière et al.
The protozoan parasite Cryptosporidium is the etiological agent of cryptosporidiosis, a ubiquitous diarrheic disease affecting humans and animals. Treatment options are limited, highlighting an urgent need for novel therapeutics. Despite de...
Ursolic acid induces apoptosis and disrupts host-parasite interactions in Theileria annulata-infected cells [0.03%]
乌索酸诱导泰勒虫感染细胞凋亡并破坏宿主寄生关系
Sakshi Singh,Madhusmita Subudhi,Vengatachala Moorthy A et al.
Sakshi Singh et al.
This study explores the anti-proliferative and anti-parasitic properties of ursolic acid (UA) in Theileria annulata-infected bovine (TA) cells. Dose-response analyses determined an IC50 value of approximately 5 μg/mL for UA, demonstrating ...
High frequency of benzimidazole resistance polymorphisms and age-class differences in trichostrongyle nematodes of ranched bison from the south-central United States [0.03%]
美国南部中央牧场野牛曲幼线虫中苯并咪唑抗性多态性的高频率及不同年龄段的影响
Kaylee R Kipp,Elizabeth M Redman,Joe L Luksovsky et al.
Kaylee R Kipp et al.
Bison production is a growing sector of the United States agriculture, with more consumers choosing bison products. Commercial bison are kept on smaller pastures and treated with anthelmintics for gastrointestinal nematodes (GIN) to maintai...
Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells [0.03%]
塔旋黄体素E能够快速抑制刚地弓形虫感染宿主细胞的能力
Fernanda G Fumuso,Jason A Clement,Matthew J Todd et al.
Fernanda G Fumuso et al.
Toxoplasmosis is a worldwide parasitic disease caused by the apicomplexan Toxoplasma gondii. Severe neurological illness occurs in immunosuppressed patients, and congenital disorders can follow transplacental primo infection during pregnanc...
The faecal egg count reduction test: Will identification of larvae to species improve its utility? [0.03%]
粪蛋计数减少测试：鉴定到虫种水平能否提高其利用价值？
Dave Leathwick,Peter Green,Charlotte Bouchet et al.
Dave Leathwick et al.
In the faecal egg count reduction test, visual identification of larvae cultured from faeces enables the egg counts to be apportioned to species/genera, resulting in a more accurate test. However, morphology cannot reliably differentiate so...
A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening [0.03%]
wrmXpress 2.0的图形用户界面简化了线虫表型筛选流程
Zachary Caterer,Rachel V Horejsi,Carly Weber et al.
Zachary Caterer et al.
Image-based phenotypic screening is a fundamental technique used to better understand the basic biology of helminths and advance discovery of new anthelmintics. Miniaturization of screening platforms and automated microscopy have led to a s...
Increased activity of CF3-derivatized levamisole at the ACC-2 receptor from the parasitic nematode Haemonchus contortus [0.03%]
在寄生线虫Haemonchus contortus的ACC-2受体上，含CF3衍生物左咪唑的活性增强
Autumn Collins,Sierra Varley,Tobias Clark et al.
Autumn Collins et al.
The acetylcholine-gated chloride channel (ACC) family in parasitic nematodes represents a promising target for anthelmintic drug development. Levamisole, a widely known and utilized cholinergic agonist, has been used for decades to address ...