Promising efficacy of nitrogen-containing bisphosphonates against the infection of Cryptosporidium spp [0.03%]
含氮双膦酸盐类药物有望成为隐孢子虫感染的有效治疗手段
Wenyan Hou,Xinyi Chen,Yingying Zhang et al.
Wenyan Hou et al.
Cryptosporidiosis is a major diarrheal disease that affects both humans and animals. Fully effective drug for treating cryptosporidiosis is still lacking. Nitrogen-containing bisphosphonates have been reported to inhibit Cryptosporidium gro...
Surveillance of single nucleotide polymorphisms correlated to macrocyclic lactone resistance in Dirofilaria immitis from client-owned dogs across the United States [0.03%]
调查美国各地客户饲养犬体内心丝虫单核苷酸多态性与大环内酯类抗生素抗药性的关联性监视项目
Emily Curry,David Tack,Jessica Rodriguez et al.
Emily Curry et al.
Dirofilaria immitis is a parasitic filarial nematode and the causative agent of heartworm disease in canids and other species. Heartworm disease is predominantly managed via macrocyclic lactone (ML) - based chemoprophylactics. Through oppor...
Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase [0.03%]
机理、计算机模拟及体外实验表明硝基呋喃具有潜在的抗利什曼病活性并能抑制半胱ein素-硫醇红酶
Julia Andrés-Rodríguez,María-Cristina González-Montero,Nerea García-Fernández et al.
Julia Andrés-Rodríguez et al.
Visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani is one of the neglected tropical diseases (NTDs) caused by trypanosomatids with treatment options limited to outdated drugs often causing adverse effects and promo...
Antimalarial drug resistance and drug discovery: learning from the past to innovate the future [0.03%]
抗疟药物耐药性与新药研发：借鉴历史教训，创新未来之路
Liana Theodoridis,Teresa G Carvalho
Liana Theodoridis
The emergence and spread of artemisinin-resistant malaria over the past 15 years has led to a recent rise in global malaria cases and represents a major public health concern. Following decades of intense research efforts, the first malaria...
Pharmacokinetics and metabolism of artemisinin (ART) in Plasmodium yoelii: ART-heme adduct as a potential biomarker for its resistance [0.03%]
青蒿素的药代动力学和代谢：抗疟有效性及相关抗药性的新视野—结合血红素的青蒿素衍生物作为一个潜在的生物学标记物
Shanshan Du,Kun Xu,Zhaohua Liu et al.
Shanshan Du et al.
Background: Plasmodium falciparum in Southeast Asia and Africa is developing resistance to the antimalarial drug artemisinin (ART). In this study, the metabolite of ART in P. yoelii parasites was evaluated as a potential ...
Type A asparagine synthetase in the zoonotic Cryptosporidium parvum (CpAsnA): Biochemical features and potential as a novel therapeutic target [0.03%]
新型兽源性隐孢子虫天冬酰胺合成酶(CpAsnA)的生化特性及其作为潜在药物靶点的可能性研究
Zongzhen Zhai,Peng Jiang,Dongqiang Wang et al.
Zongzhen Zhai et al.
Cryptosporidium parvum is an intestinal protozoan parasite, the causative agent of the diarrheal cryptosporidiosis in humans and animals for which fully effective treatments are yet unavailable. The C. parvum genome encodes highly streamlin...
Martin K Nielsen,Alison Pyatt,Jodie Perrett et al.
Martin K Nielsen et al.
Equine parasite control has historically been characterized by confusing and conflicting information, posing significant challenges for veterinarians and horse owners to make evidence-based decisions. Since 2012, equine parasite control gui...
Combination astragaloside IV and artesunate preserves blood-brain barrier integrity by modulating astrocytes and tight junction proteins in Plasmodium yoelii infection [0.03%]
astragaloside IV和青蒿素通过调节星形胶质细胞和紧密连接蛋白来维护 Plasmodium yoelii 感染的血脑屏障的完整性
Phornyupa Sanguanwong,Ladawan Khowawisetsut,Lanaprai Kwathai et al.
Phornyupa Sanguanwong et al.
Background: Astragaloside IV (ASIV), a natural compound from Astragalus membranaceus, exerts neuroprotective and anti-inflammatory effects in various pathologies. Its role in Plasmodium yoelii (Py) 17XL-induced inflammati...
Three Asparagine insertions in the K13-propeller led to Plasmodiumfalciparum becoming resistant to multiple antimalarial drugs [0.03%]
K13胡椒传播中的三个天冬酰胺插入使恶性疟原虫对多种抗疟药产生耐药性
Zheng Xiang,Mengxi Duan,Siqi Wang et al.
Zheng Xiang et al.
Drug resistance in Plasmodium falciparum represents a significant challenge in malaria treatment. Identifying the molecular markers associated with P. falciparum resistance will effectively detect resistance and enhance treatment efficiency...
New derivatives of benzhydroxamic acid with nematocidal activity against Haemonchus contortus and Caenorhabditis elegans [0.03%]
具有盘尾丝虫活性的苯胲类衍生物的新化合物及其制备方法和应用
Josef Krátký,Markéta Zajíčková,Aya C Taki et al.
Josef Krátký et al.
Parasitic nematodes cause a wide range of diseases in animals, including humans. However, the efficacy of existing anthelmintic drugs, commonly used to treat these infections, is waning due to the increasing prevalence of drug resistance in...