Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis [0.03%]
铅丹和血根碱可有效治疗血吸虫病
Si-Ming Zhang,Kristen A Coultas
Si-Ming Zhang
Schistosomiasis, a snail-borne parasitic disease, affects more than 200 million people worldwide. Currently the treatment of schistosomiasis relies on a single therapy of praziquantel, a drug developed over 30 years ago. Thus, there is an u...
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds [0.03%]
基于结构的新型病原体特异性抑制剂支架的发展及CYP51酶的结构研究
Tatiana Y Hargrove,Kwangho Kim,Maria de Nazaré Correia Soeiro et al.
Tatiana Y Hargrove et al.
CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infectio...
Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy? [0.03%]
恶性疟原虫对青蒿素的耐药性与休眠有关吗？
Qin Cheng,Dennis E Kyle,Michelle L Gatton
Qin Cheng
Artemisinin (ART) based combination therapy (ACT) is used as the first line treatment of uncomplicated falciparum malaria in over 100 countries and is the cornerstone of malaria control and elimination programs in these areas. However, desp...
Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease [0.03%]
恰加斯病的甾醇14-脱甲基酶抑制剂最新研究进展
Frederick S Buckner,Julio A Urbina
Frederick S Buckner
The protozoan parasite, Trypanosoma cruzi, causes the most prevalent parasitic infection in the American continent. It gives rise to life-long infection in humans and results in severe cardiomyopathy or other life-threatening manifestations...
The Entamoeba histolytica serum-inducible transmembrane kinase EhTMKB1-9 is involved in intestinal amebiasis [0.03%]
伊氏利什曼原虫诱导的跨膜蛋白激酶EhTMKB1-9与肠阿米巴病有关
Mayuresh M Abhyankar,Shiteshu Shrimal,Carol A Gilchrist et al.
Mayuresh M Abhyankar et al.
Entamoeba histolytica possesses a family of approximately 100 putative transmembrane kinases (TMKs), indicating that the parasite has an extensive means of environmental sensing. The TMKs have been divided into nine sub-groups based on the ...
Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target [0.03%]
恶二唑并二氧化物对于人的钩虫，斯里兰卡ANCYLOSTOMA有毒性，但是谷胱甘肽还原酶不是主要目标
R S Treger,A G Cook,G Rai et al.
R S Treger et al.
Hookworm disease, characterized by severe anemia and cognitive and growth delays, currently affects an estimated 740 million people worldwide. Despite the prevalence of this parasitic disease, few effective drug therapies are in use today, ...
Degrees of chloroquine resistance in Plasmodium - is the redox system involved? [0.03%]
氯喹抗药性程度与红斑相关？
Adele M Lehane,Christopher A McDevitt,Kiaran Kirk et al.
Adele M Lehane et al.
Chloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intraerythrocytic phase of its life...