Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast [0.03%]
秀丽线虫FLP-2受体(T19F4.1)真核表达载体的构建及鉴定
Martha J Larsen,Elizabeth Ruiz Lancheros,Tracey Williams et al.
Martha J Larsen et al.
Profound neuropeptide diversity characterizes the nematode nervous system, but it has proven challenging to match neuropeptide G protein-coupled receptors (GPCR) with their cognate ligands in heterologous systems. We have expressed the Caen...
Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis [0.03%]
用于人类非洲锥虫病的新型治疗方法的识别和发展的基于活性染料的高通量筛选方法的应用
Tana Bowling,Luke Mercer,Robert Don et al.
Tana Bowling et al.
Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei, and the disease is fatal if untreated. There is an urgent need to develop new, safe and effective treatments for HAT because current drugs have extr...
Chemotherapeutics challenges in developing effective treatments for the endemic malarias [0.03%]
化疗药物在开发有效地方性疟疾治疗方案中的挑战
J Kevin Baird
J Kevin Baird
The endemic malarias threaten the several billion people residing where transmission occurs. Chemotherapeutic strategy pitted against these threats hinges upon species- and stage-specific treatments guided by diagnosis and screening against...
Recent highlights in anti-protozoan drug development and resistance research [0.03%]
近年来反原生动物药物开发和抗药性研究的重要成果
Frederick S Buckner,Norman C Waters,Vicky M Avery
Frederick S Buckner
This article summarizes the highlights of research presented in January, 2012, at the Keystone Symposium on "Drug Discovery for Protozoan Parasites" held in Santa Fe, New Mexico. This symposium which convenes approximately every 2 years pro...
Effects of the green tea catechin (-)-epigallocatechin gallate on Trypanosoma brucei [0.03%]
(-)-表没食子儿茶素没食子酸酯对布氏锥虫的影响
Patrick A Vigueira,Sunayan S Ray,Ben A Martin et al.
Patrick A Vigueira et al.
The current pharmacopeia to treat the lethal human and animal diseases caused by the protozoan parasite Trypanosoma brucei remains limited. The parasite's ability to undergo antigenic variation represents a considerable barrier to vaccine d...
Distribution patterns of three sodium channel mutations associated with pyrethroid resistance in Rhipicephalus (Boophilus) microplus populations from North and South America, South Africa and Australia [0.03%]
三种钠通道突变在南北美洲、南非和澳大利亚的微小牛蜱种群中的分布模式：与拟除虫菊酯抗性相关
Leonore Lovis,Felix D Guerrero,Robert J Miller et al.
Leonore Lovis et al.
Resistance to synthetic pyrethroids (SP) in the cattle tick Rhipicephalus (Boophilus) microplus is widespread throughout its distribution area. Three single nucleotide substitutions identified in Domains II and III of the sodium channel gen...
Current treatment options for Dientamoeba fragilis infections [0.03%]
Dientamoeba脆弱氏体感染的 current治疗选项
Noriyuki Nagata,Deborah Marriott,John Harkness et al.
Noriyuki Nagata et al.
Dientamoeba fragilis belongs to the trichomonad group of protozoan parasites and it has been implicated as a cause of gastrointestinal disease with world-wide prevalences ranging from 0.5% to 16%. The majority of patients with dientamoebias...
Antimony resistance and environment: Elusive links to explore during Leishmania life cycle [0.03%]
抗锑性和环境：利什曼原虫生活周期中的隐秘联系等待探索
Denis Sereno,Carla Maia,Khatima Aït-Oudhia
Denis Sereno
Leishmania drug resistance and particularly antimony resistance still continues to emerge in different part of the world. Because visceral and cutaneous leishmaniasis are transmitted in foci with zoonotic or anthroponotic life-cycles, the l...
Philipp Ludin,Ben Woodcroft,Stuart A Ralph et al.
Philipp Ludin et al.
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here we aim to identify new drug targets in Plasmodium falciparum by phylogenomics among the Plasmodium spp. and comparative genomics to Homo sap...
Matthew R Hepworth,Susanne Hartmann
Matthew R Hepworth
In a recent issue of "The International Journal for Parasitology: Drugs and Drug Resistance" Prof. David Pritchard from the University of Nottingham offers his intriguing opinion on the current status of "worm therapy" and outlines future r...