Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1 [0.03%]
鉴定出赋予弓形虫抗1NM-PP1能力的TgMAPK1突变体
Tatsuki Sugi,Kyousuke Kobayashi,Hitoshi Takemae et al.
Tatsuki Sugi et al.
Toxoplasma gondii is an important food and waterborne pathogen that causes severe disease in immunocompromised patients. Bumped kinase inhibitors (BKIs) have an antiparasitic effect on T. gondii tachyzoite growth by targeting T. gondii calm...
Quantitative assessment of the proliferation of the protozoan parasite Perkinsus marinus using a bioluminescence assay for ATP content [0.03%]
定量评估火体虫原生动物寄生虫的增殖情况的方法及使用生物发光法测定ATP含量
Surekha Shridhar,Kolaleh Hassan,David J Sullivan et al.
Surekha Shridhar et al.
Perkinsus marinus is a protozoan parasite that causes "Dermo" disease in the eastern oyster Crasssostrea virginica in coastal areas of the USA. Until now, intervention strategies against the parasite have found limited success, and Dermo st...
A comparative study of the effects of four treatment regimes on ivermectin efficacy, body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland [0.03%]
四种治疗方案对天然感染胃肠线虫的苏格兰羔羊伊维菌素疗效、体重和牧草地污染效果影响的比较研究
Fiona Kenyon,David McBean,Andrew W Greer et al.
Fiona Kenyon et al.
Refugia-based drenching regimes have been widely recommended to slow development of anthelmintic resistance but there are few comparisons between different treatment approaches in the UK. The impact of four ivermectin treatment regimes on d...
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake [0.03%]
功能表达的TcoAT1是具有摄取能力的P1型核苷转运蛋白，不适用于底氮唑摄取
Jane C Munday,Karla E Rojas López,Anthonius A Eze et al.
Jane C Munday et al.
It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol. Accordingly, it was proposed t...
Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites [0.03%]
三氟磺醚𬭩盐类似物对体外培养的东毕吸虫幼虫生长抑制作用评价
Marta G Silva,Ana Domingos,M Alexandra Esteves et al.
Marta G Silva et al.
Bovine babesiosis, caused by Babesia bovis, is a global tick borne hemoprotozoan parasite disease characterized by fever, anemia, weight losses and ultimately death. Several babesicidal drugs that have been in use in cattle for years have p...
Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus [0.03%]
左旋咪唑敏感和耐药捻转血矛线虫乙酰胆碱受体亚单位和P-糖蛋白的表达模式
Ranbir S Sarai,Steven R Kopp,Glen T Coleman et al.
Ranbir S Sarai et al.
The mechanism of resistance to the anthelmintic levamisole in parasitic nematodes is poorly understood, although there is some evidence implicating changes in expression of nicotinic acetylcholine receptor (nAChR) subunit genes. Hence, in o...
Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children [0.03%]
青蒿素治疗后加纳无症状学龄儿童的恶性疟原虫、间日疟原虫古典型、卵形疟原虫沃氏亚种和卵形疟原虫柯瑞式的持续检测结果
Bismarck Dinko,Mary C Oguike,John A Larbi et al.
Bismarck Dinko et al.
Two hundred and seventy four asymptomatic Ghanaian school-children aged 5 to 17 years were screened for malaria parasites by examination of blood films. One hundred and fifty five microscopically-positive individuals were treated with dihyd...
Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE) [0.03%]
应用差异凝胶电泳技术(DIGE)筛选并鉴定沙培南敏感和耐药毒力株表达蛋白的区别谱型及差异蛋白质点
Christelle Doliwa,Dong Xia,Sandie Escotte-Binet et al.
Christelle Doliwa et al.
Treatment options for toxoplasmosis in humans are generally limited to the use of sulfonamide and/or pyrimethamine-based compounds. However, there is increasing evidence for clinical therapy failures in patients suggesting the existence of ...
Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression [0.03%]
莫西菌素、阿巴菌素和伊维菌素治疗感染耐药性线虫羔羊的比较组织药代动力学及疗效：药物对寄生虫P-糖蛋白表达的影响
Mercedes Lloberas,Luis Alvarez,Carlos Entrocasso et al.
Mercedes Lloberas et al.
The high level of resistance to the macrocyclic lactones has encouraged the search for strategies to optimize their potential as antiparasitic agents. There is a need for pharmaco-parasitological studies addressing the kinetic-dynamic diffe...
Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine [0.03%]
恶性疟原虫Na+/H+交换器(pfnhe-1)等位基因多态性分析及其作为体外抗金鸡纳碱耐药标志物的使用价值
Didier Ménard,Valérie Andriantsoanirina,Nimol Khim et al.
Didier Ménard et al.
The aim of this study was to provide a comprehensive analysis of the worldwide genetic polymorphism of ms4760 alleles of the pfnhe-1 gene and to discuss their usefulness as molecular marker of quinine resistance (QNR). A new numbering of ms...