Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism [0.03%]
米替福新作用于利什曼原虫的非靶向代谢组学分析揭示了其对内部脂质代谢的影响
Isabel M Vincent,Stefan Weidt,Luis Rivas et al.
Isabel M Vincent et al.
There are many theories as to the mode of action of miltefosine against Leishmania including alterations to the membrane lipid content, induction of apoptosis and modulation of macrophage responses. Here we perform untargeted metabolomics t...
Duplex quantitative Reverse-Transcriptase PCR for simultaneous assessment of drug activity against Leishmania intracellular amastigotes and their host cells [0.03%]
用于同时评估药物对利什曼原虫胞内无鞭毛体及其宿主细胞活性的双链定量反转录PCR法
Erika van den Bogaart,Gerard J Schoone,Emily R Adams et al.
Erika van den Bogaart et al.
Currently available drugs for treatment of Leishmania infections are highly toxic and drug resistance to first line therapies has been observed. New, safer and more effective drugs are urgently needed to improve clinical resolution of the d...
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites [0.03%]
氨酰-tRNA合成酶作为真核寄生虫药物靶标的可能性
James S Pham,Karen L Dawson,Katherine E Jackson et al.
James S Pham et al.
Aminoacyl-tRNA synthetases are central enzymes in protein translation, providing the charged tRNAs needed for appropriate construction of peptide chains. These enzymes have long been pursued as drug targets in bacteria and fungi, but the pa...
Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition [0.03%]
探索吴司林素抑制布氏锥虫己糖激酶的作用机制
April C Joice,Michael T Harris,Elizabeth W Kahney et al.
April C Joice et al.
Glycolysis is essential to Trypanosoma brucei, the causative agent of African sleeping sickness, suggesting enzymes in the pathway could be targets for drug development. Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one, EbSe) was identified...
Molecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony [0.03%]
四种新世界利什曼原虫(MRPA)转运蛋白的分子特征及对锑元素的摄取能力及其是否抗药性的表征
Douglas S Moreira,Rubens L Monte Neto,Juvana M Andrade et al.
Douglas S Moreira et al.
ATP-binding cassette (ABC) transporters have been associated with drug resistance in various diseases. The MRPA gene, a transporter of ABCC subfamily, is involved in the resistance by sequestering metal-thiol conjugates in intracellular ves...
Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal [0.03%]
塞内加尔蒂斯疟疾患者红细胞外阶段恶性疟原虫dhfr/dhps基因多态性、虫密度及比海明胺的药敏关系研究
Daouda Ndiaye,Baba Dieye,Yaye D Ndiaye et al.
Daouda Ndiaye et al.
Resistance to sulfadoxine-pyrimethamine (SP) in Plasmodium falciparum malaria parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes, and these mutations have spread resistance...
Limited efficacy of pour-on anthelmintic treatment of cattle under Swedish field conditions [0.03%]
瑞典实地条件下牛驱虫作用有限
Marlene Areskog,Bitte Ljungström,Johan Höglund
Marlene Areskog
A study on the effect of topical macrocyclic lactones (ML) against gastrointestinal nematodes (GIN) in Swedish first season grazing cattle (FSG) was performed during the grazing seasons of 2009 and 2010. Herds were recruited through farming...
Proposal for a new therapy for drug-resistant malaria using Plasmodium synthetic lethality inference [0.03%]
利用疟原虫合成致死推理提出一种新的耐药性疟疾疗法的建议
Sang Joon Lee,Eunseok Seo,Yonghyun Cho
Sang Joon Lee
Many antimalarial drugs kill malaria parasites, but antimalarial drug resistance (ADR) and toxicity to normal cells limit their usefulness. To solve this problem, we suggest a new therapy for drug-resistant malaria. The approach consists of...
The in vitro assay profile of macrocyclic lactone resistance in three species of sheep trichostrongyloids [0.03%]
三类羊尾线虫体外巨环内酯类药物抗性检测方法的评价研究
Janina Demeler,Jennifer H Gill,Georg von Samson-Himmelstjerna et al.
Janina Demeler et al.
Anthelmintic resistance has emerged as an important problem in animal industries. Understanding resistance mechanisms, especially against macrocyclic lactones (MLs), is the first step in developing better diagnostic tools. Effects of severa...
Development of an in vitro bioassay for measuring susceptibility to macrocyclic lactone anthelmintics in Dirofilaria immitis [0.03%]
体内生物测定法测定马拉色菌抗生素对迪罗菲拉米蒂斯的敏感性的发展
Christopher C Evans,Andrew R Moorhead,Bobby E Storey et al.
Christopher C Evans et al.
For more than 20 years, anthelmintics of the macrocyclic lactone (ML) drug class have been widely and effectively used as preventives against the canine heartworm, Dirofilaria immitis. However, in recent years an increased number of lack of...