Tina V A Hansen,Christian Friis,Peter Nejsum et al.
Tina V A Hansen et al.
It is recognized that the clinical efficacy of single dose benzimidazoles (BZs) against the nematode, Trichuris suis of pigs and the closely related Trichuris trichiura in humans is only poor to moderate. Recent in vitro studies have indica...
Katherine T Andrews,Gillian Fisher,Tina S Skinner-Adams
Katherine T Andrews
Parasitic diseases have an enormous health, social and economic impact and are a particular problem in tropical regions of the world. Diseases caused by protozoa and helminths, such as malaria and schistosomiasis, are the cause of most para...
microRNAs of parasitic helminths - Identification, characterization and potential as drug targets [0.03%]
寄生线虫的微小RNA-鉴定、表征及其作为药物靶点的潜力
Collette Britton,Alan D Winter,Victoria Gillan et al.
Collette Britton et al.
microRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. They were first identified in the free-living nematode Caenorhabditis elegans, where the miRNAs lin-4 and let-7 were shown to be essential for re...
Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro [0.03%]
体外实验中能够存活不断增加浓度左旋咪唑的古柏线虫幼虫的药物流出和靶点基因表达模式
Ranbir S Sarai,Steven R Kopp,Glen T Coleman et al.
Ranbir S Sarai et al.
While there is some evidence that changes in nicotinic acetylcholine receptor (nAChR) subunits confer resistance to levamisole in gastrointestinal helminth parasites, the exact nature of the resistance mechanism(s) is unclear. We utilised t...
High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms [0.03%]
钩丝虫的生殖组织中一种高表达的谷氨酸氯通道基因可能是伊维菌素导致丝虫绝育的原因
Ben Wen Li,Amy C Rush,Gary J Weil
Ben Wen Li
Glutamate-gated chloride channels (GluCl) are targets for avermectin/milbemycin (A/M) anthelmintics such as ivermectin that cause paralysis of somatic and pharyngeal muscles in gastrointestinal nematodes. Ivermectin is useful for onchocerci...
Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana [0.03%]
泊松分布质量控制措施在加纳两项人体钩虫病药物治疗研究中的应用分析
Andrew C Kotze,Robert J Dobson,Debbie Humphries et al.
Andrew C Kotze et al.
We examined faecal egg count reduction tests (FECRTs) conducted with hookworm-infected humans in Ghana in 2007 (study 1) and 2010 (study 2) in order to explore aspects of the test analysis. Some subjects showed increased FEC following drug ...
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [0.03%]
腺嘌呤-磷酸核糖转移酶介导的特异性调节物介导的吸血虫素布鲁西亚腺嘌呤回收和氨基嘌呤醇敏感性而不是腺嘌呤毒性
Alexandra Lüscher,Estelle Lamprea-Burgunder,Fabrice E Graf et al.
Alexandra Lüscher et al.
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involve...
Confirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle [0.03%]
特拉硝唑对澳大利亚感染肝片吸虫肉牛和奶牛无效的确认
Yvette M Brockwell,Timothy P Elliott,Glenn R Anderson et al.
Yvette M Brockwell et al.
Triclabendazole (TCBZ) is the drug of choice for Fasciola hepatica control and reports of F. hepatica resistant to this drug from a wide range of geographic regions are very concerning. This study investigated the presence of TCBZ resistanc...
A novel marker, ARM58, confers antimony resistance to Leishmania spp [0.03%]
一种新的标记物ARM58使利什曼原虫属细胞对抗砷剂产生耐药性
Andrea Nühs,Carola Schäfer,Dorothea Zander et al.
Andrea Nühs et al.
Protozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and ...
Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites [0.03%]
新型S-腺苷蛋氨酸去羧酶抑制剂对红细胞内疟原虫具有较强的抗增殖活性
Dina le Roux,Pieter B Burger,Jandeli Niemand et al.
Dina le Roux et al.
S-adenosyl-l-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. Derivatives of an irrever...