Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production [0.03%]
鸡预防球虫病疫苗有助于商业养鸡业缓解药物耐药性问题
H David Chapman,Thomas K Jeffers
H David Chapman
Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by...
Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis [0.03%]
一种新型羟乙基哌嗪类似物PMIC4治疗利什曼原虫亚马逊亚种的口服有效性的研究
Mariela Ferreira de Vasconcelos,Edézio Ferreira da Cunha-Júnior,Valter Viana de Andrade-Neto et al.
Mariela Ferreira de Vasconcelos et al.
Pentavalent antimonials have saved the lives of thousands of Leishmania-infected patients more than seventy years but, unfortunately, they are highly toxic and require parenteral delivery. Therefore, the search for safer and orally delivere...
A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts [0.03%]
一种评估药物对细胞内环形泰勒虫速殖子活性的定量反转录PCR测定法
Isabel Hostettler,Joachim Müller,Chad E Stephens et al.
Isabel Hostettler et al.
Intracellular schizonts of the apicomplexans Theileria annulata and Theileria parva immortalize bovine leucocytes thereby causing fatal immunoproliferative diseases. Buparvaquone, a hydroxynaphthoquinone related to parvaquone, is the only d...
Gordana Panic,Urs Duthaler,Benjamin Speich et al.
Gordana Panic et al.
Helminth infections are responsible for a considerable public health burden, yet the current drug armamentarium is small. Given the high cost of drug discovery and development, the high failure rates and the long duration to develop novel t...
Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions [0.03%]
抗虫剂耐药标记物的鉴定及药物/受体相互作用描述方面的新进展：候选基因与全基因组方法
Andrew C Kotze,Peter W Hunt,Philip Skuce et al.
Andrew C Kotze et al.
Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Conso...
Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya [0.03%]
基线效力调查：肯尼亚沿海地区二十年来抗疟药物政策变化导致恶性疟原虫抗性基因型变化趋势（1997-2017）
John Okombo,Alice W Kamau,Kevin Marsh et al.
John Okombo et al.
Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures. To assess temporal trends of established genotypes as...
Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes [0.03%]
大环内酯类药物莫西菌素的抗性部分由膜转运蛋白P-糖蛋白介导：对寄生线虫耐药控制的意义
Elizabeth E Bygarski,Roger K Prichard,Bernadette F Ardelli
Elizabeth E Bygarski
Our objective was to determine if the resistance mechanism to moxidectin (MOX) is similar of that to ivermectin (IVM) and involves P-glycoproteins (PGPs). Several Caenorhabditis elegans strains were used: an IVM and MOX sensitive strain, 13...
Antony P Page,Gillian Stepek,Alan D Winter et al.
Antony P Page et al.
All nematodes possess an external structure known as the cuticle, which is crucial for their development and survival. This structure is composed primarily of collagen, which is secreted from the underlying hypodermal cells. Extensive studi...
Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum [0.03%]
利什曼原塘亚种胺苯砜耐药性的定量蛋白质组分析
Marie-Christine Brotherton,Sylvie Bourassa,Danielle Légaré et al.
Marie-Christine Brotherton et al.
Amphotericin B (AmB) in its liposomal form is now considered as either first- or second-line treatment against Leishmania infections in different part of the world. Few cases of AmB resistance have been reported and resistance mechanisms to...
Idiosyncratic quinoline central nervous system toxicity: Historical insights into the chronic neurological sequelae of mefloquine [0.03%]
异喹啉类中枢神经系统毒性的特异性：氯喹长期神经后遗症的历史见解
Remington L Nevin
Remington L Nevin
Mefloquine is a quinoline derivative antimalarial which demonstrates promise for the treatment of schistosomiasis. Traditionally employed in prophylaxis and treatment of chloroquine-resistant Plasmodium falciparum malaria, recent changes to...