Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug [0.03%]
肯尼亚曼氏血吸虫对吡喹酮敏感性研究及实验室低敏感株系的建立
Ibrahim N Mwangi,Melissa C Sanchez,Gerald M Mkoji et al.
Ibrahim N Mwangi et al.
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel. The near exclusiv...
Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib [0.03%]
白蛋白和α-1酸性糖蛋白阻碍伊马替尼对曼氏血吸虫的杀灭作用
Svenja Beckmann,Thavy Long,Christina Scheld et al.
Svenja Beckmann et al.
In the search for new drugs and drug targets to treat the flatworm disease schistosomiasis, protein kinases (PKs) have come under particular scrutiny because of their essential roles in developmental and physiological processes in schistoso...
Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis [0.03%]
从人类药典中重新定位approved药物以靶向盘尾丝虫病和淋巴丝虫病的沃尔巴克氏体内共生菌
Kelly L Johnston,Louise Ford,Indira Umareddy et al.
Kelly L Johnston et al.
Lymphatic filariasis and onchocerciasis are debilitating diseases caused by parasitic filarial nematodes infecting around 150 million people throughout the tropics with more than 1.5 billion at risk. As with other neglected tropical disease...
Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia [0.03%]
马来丝虫半胱氨酸蛋白酶潜在参与与沃尔巴克氏体的内共生关系维护作用中英文标题翻译
Sara Lustigman,Elena Melnikow,Setty Balakrishnan Anand et al.
Sara Lustigman et al.
Brugia malayi, a parasitic nematode that causes lymphatic filariasis, harbors endosymbiotic intracellular bacteria, Wolbachia, that are required for the development and reproduction of the worm. The essential nature of this endosymbiosis le...
Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis [0.03%]
化合物库筛选鉴定出Akt/PKB激酶途径抑制剂可能是开发新的抗血吸虫病化疗药物的关键分子
Marion Morel,Mathieu Vanderstraete,Katia Cailliau et al.
Marion Morel et al.
Protein kinases (PKs) are one of the largest protein families in most eukaryotic organisms. These enzymes are involved in the control of cell proliferation, differentiation and metabolism and a large number of the anticancer drugs currently...
Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics [0.03%]
扁虫谷氨酸门控氯离子通道和圆虫的比较药理学及其对潜在驱虫药物的影响
Timothy Lynagh,Brett A Cromer,Vanessa Dufour et al.
Timothy Lynagh et al.
Pharmacological targeting of glutamate-gated chloride channels (GluCls) is a potent anthelmintic strategy, evidenced by macrocyclic lactones that eliminate numerous roundworm infections by activating roundworm GluCls. Given the recent ident...
Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator" [0.03%]
计算机处理高清视频成像技术在测量微丝虫各个阶段运动性方面的应用：“Worminator”系统
Bob Storey,Chris Marcellino,Melissa Miller et al.
Bob Storey et al.
A major hindrance to evaluating nematode populations for anthelmintic resistance, as well as for screening existing drugs, new compounds, or bioactive plant extracts for anthelmintic properties, is the lack of an efficient, objective, and r...
Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics [0.03%]
秀丽杆线虫和寄生线虫的自动、高通量运动分析：在寻找新型抗蠕虫药物中的应用
Steven D Buckingham,Frederick A Partridge,David B Sattelle
Steven D Buckingham
The scale of the damage worldwide to human health, animal health and agricultural crops resulting from parasitic nematodes, together with the paucity of treatments and the threat of developing resistance to the limited set of widely-deploye...
WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships [0.03%]
通过跨行业合作加速抗蠕虫药物的研发 WIPO Re:search项目案例分析
Roopa Ramamoorthi,Katy M Graef,Jennifer Dent
Roopa Ramamoorthi
Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6 billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of ne...
Adrian J Wolstenholme,Richard J Martin
Adrian J Wolstenholme
The scientific meeting entitled 'Anthelmintics: From Discovery to Resistance' was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites wer...