In vitro and in vivo anti-piroplasm activity of PBT2 against Theileria annulata and Babesia microti [0.03%]
PBT2体外和体内的抗皮罗孢子虫活性：针对环形泰勒虫和微小巴贝斯虫的研究
Jin Che,Yixuan Wu,Junwei Wang et al.
Jin Che et al.
Theileriosis and babesiosis remain major constraints to livestock production, and increasing drug resistance necessitates alternative therapeutic strategies. Here, we evaluated the metal ionophore PBT2 for anti-piroplasm activity. PBT2 inhi...
A novel 2-piperazino-pyrimidine compound exhibits asexual antimalarial activity by targeting Plasmodium falciparum plasmepsin X [0.03%]
一种新型的2-哌嗪并嘧啶化合物通过靶向Plasmodium falciparum plasmepsin X表现出抗疟活性
Jing Hong,Takaya Sakura,Naoya Asada et al.
Jing Hong et al.
Although the number of cases of malaria has declined since the introduction of artemisinin-based combination therapy in endemic countries, the emergence of resistant parasites in the field has led to an alarming increase in treatment failur...
The detection of three independent benzimidazole resistance mutations in a single Ancylostoma caninum population from a Golden Retriever breeding kennel in Sao Paulo, Brazil [0.03%]
巴西圣保罗一只金毛寻回器繁殖母犬体内独立的三种苯并咪唑抗性突变的检测
Mahya Dini,Rebecca Chen,Elizabeth Redman et al.
Mahya Dini et al.
Multiple anthelmintic drug resistance (MADR) is widespread in the canine hookworm Ancylostoma caninum in kenneled greyhounds in the USA and Australia with benzimidazole resistance being associated with the isotype-1 β-tubulin SNPs Q134H(CA...
Pharmacology and toxicology of veterinary isoxazolines: a review [0.03%]
veterinarium 异唑啉类药物的药理学和毒理学：综述
Paulina Markowska-Buńka,Bartosz Rasiński,Hubert Ziółkowski
Paulina Markowska-Buńka
Isoxazoline derivatives have rapidly become cornerstone ectoparasiticides in veterinary medicine, providing high efficacy and long-lasting protection against fleas, ticks, and other arthropods in companion animals and, more recently, in foo...
Terpenic compounds possess anthelmintic and immunomodulatory properties with potential for controlling equine cyathostomin infections [0.03%]
单萜类化合物具有驱虫和免疫调节作用 有望用于控制马圆线虫属感染
Joshua Malsa,Angélique Chereau,Fabrice Guégnard et al.
Joshua Malsa et al.
The emergence of anthelmintic-resistant parasite isolates necessitates alternative control strategies. The use of dietary additives with anti-parasitic or immunomodulatory activities has been proposed as a solution, but whether such additiv...
Screening of purine nucleoside analogues against intracellular Toxoplasma gondii [0.03%]
嘌呤核苷类似物抗细胞内弓形虫的筛选研究
Hamza A A Elati,Serge Van Calenbergh,Lilach Sheiner et al.
Hamza A A Elati et al.
Toxoplasmosis remains a world-wide public health concern, especially for the immunocompromised. Although this population segment is increasing due to therapeutic interventions, organ transplants and infections including HIV, treatment relie...
Pharmacokinetics of fenbendazole and its bioactive metabolite oxfendazole in northern bobwhite administered an anthelmintic feed [0.03%]
药理学：鸡传染性法氏囊病疫苗毒株的评价与选择
Hannah N Suber,Dhavalkumar Patel,Timothy B Arlowe et al.
Hannah N Suber et al.
The northern bobwhite (Colinus virginianus) has experienced significant population declines across its native range. Parasitic nematodes are increasingly being recognized as contributing factors. QuailGuard®, an anthelmintic feed that uses...
High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes [0.03%]
针对疟原虫高通量表型筛选发现新的线虫抑制化学类型
Aya C Taki,Joseph J Byrne,Bill C H Chang et al.
Aya C Taki et al.
Parasitic helminths impose substantial health and economic burdens on humans and livestock, and widespread resistance to existing anthelmintic classes underscores the urgent need for new chemotypes with distinct mechanisms of action as part...
TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants [0.03%]
TRPtracker：一个用于监测praziquantel在TRPMPZQ变异体中敏感性的社区数据库
Claudia M Rohr,Sang-Kyu Park,Kelsilandia Aguiar-Martins et al.
Claudia M Rohr et al.
The anthelmintic praziquantel (PZQ) has been used for decades as the clinical therapy for schistosomiasis, and remains the only available drug. As a cheap and effective drug therapy for all human disease-causing Schistosoma species, usage o...
P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans [0.03%]
庞抗蛋白和感觉器官：伊维菌素在秀丽隐杆线虫中耐药性的两阶段发展轨迹
Lucas Barat,Eva Guchen,Clara Blancfuney et al.
Lucas Barat et al.
Ivermectin (IVM) is a cornerstone of nematode control. However, its efficacy is increasingly compromised by emerging resistance in target parasites. P-glycoproteins (Pgps), which mediate drug efflux, and amphid neuron defects, characterized...