Characterization of two early lead anti-amoebic agents with activity against Naegleria fowleri [0.03%]
两种早期的抗阿米巴制剂具有杀灭福氏耐格里阿米巴原虫活性的特征分析
Caroline M Palmentiero,Jillian E M McKeon,Colm P Roster et al.
Caroline M Palmentiero et al.
Brain infection by the pathogenic free-living amoebae Naegleria fowleri is a life-threatening illness, with a mortality rate >95% in the US. One of the challenges faced in treating these infections is the lack of efficacious drugs. Here, we...
Widespread use of nitroimidazoles in competition pigeons reduced their effectiveness against Trichomonas gallinae [0.03%]
硝基咪唑类药物在竞翔鸽中的广泛应用使其对_trichomonas gallinae_的效果降低
M García-Piqueras,R Suarez Lombao,P Pérez Moreno et al.
M García-Piqueras et al.
Trichomonas gallinae is a protozoan parasite of major concern in avian medicine, particularly in domestic pigeons (Columba livia). This study investigated the nitroimidazole susceptibility and T. gallinae occurrence in domesticated pigeons ...
Characterising anthelmintic resistance to benzimidazoles and macrocyclic lactones in gastrointestinal nematodes of dairy cattle [0.03%]
牛胃肠道线虫苯并咪唑和大环内酯类抗性的特征研究
Paul Campbell,Jennifer Mcintyre,Alistair Antonopoulos et al.
Paul Campbell et al.
Anthelmintic resistance in gastrointestinal nematodes (GIN) of cattle is of increasing concern, but the number of studies monitoring anthelmintic efficacy is insufficient to provide a representative picture. In this study, resistance to mac...
Benzimidazole resistance in Haemonchus contortus in small ruminants: molecular mechanisms and diagnostic approaches [0.03%]
羊发生于小反刍动物的盘尾丝虫苯并咪唑抗性：分子机制与诊断方法
Zofia Nowek,Marcin Mickiewicz,Alistair Antonopoulos et al.
Zofia Nowek et al.
Benzimidazole resistance in Haemonchus contortus represents a widespread challenge in small ruminant production worldwide. Benzimidazoles remain one of the most commonly used drug classes, due to their broad spectrum of activity, affordabil...
Morin inhibits fructose bisphosphate aldolase activity and resists Cryptosporidium parvum infection [0.03%]
摩里宁抑制果糖-1,6-二磷酸醛缩酶活性并抵抗小隐孢子虫感染
Mengge Chen,Hongyan Kang,Yanhui Yu et al.
Mengge Chen et al.
Cryptosporidium parvum is a zoonotic intestinal protozoan that causes severe diarrhea in children and immunocompromised individuals. The lack of effective therapies underscores the urgent need for novel drug targets. As C. parvum primarily ...
Anaphalis margaritacea ethanol extract exhibits potent anti-Trichinella spiralis activity via mitochondrial dysfunction and host tissue protection [0.03%]
蒲公英.marginargarat醋提物通过诱导线粒体功能障碍和保护宿主组织展现对旋毛虫的活性
Xiaoyan Yu,Xinyuan Cao,Yuchao Ma et al.
Xiaoyan Yu et al.
Trichinellosis is a food-borne zoonosis caused by Trichinella spiralis, for which effective treatment against the muscle larvae stage remains limited. To identify new anti-T. spiralis agents from medicinal plants, 30 extracts with reported ...
Screening and evaluation of potential histone deacetylase inhibitors against Babesia infections [0.03%]
巴贝斯虫感染的组蛋白去乙酰化酶抑制剂筛选及评价研究
Xinxin Zhang,Yubin Li,Jin Che et al.
Xinxin Zhang et al.
Babesia spp., a group of blood protozoa transmitted via the bites of tick vectors, cause enormous economic losses for livestock industry and pose significant risk to public health. Currently, the drugs available for treating babesiosis are ...
In vitro profiling of Trypanosoma cruzi inhibitors identified from High throughput Screening and application to parasite painting [0.03%]
基于高通量筛选查尔斯吉氏克雅菌抑制剂的体外分析及其在绘制寄生虫染色中的应用
Kyung-Hwa Baek,Hyeryon Lee,Sooyoung Byun et al.
Kyung-Hwa Baek et al.
Chagas disease, a neglected tropical disease caused by Trypanosoma cruzi, urgently requires next-generation therapeutics due to the limitations of use of benznidazole and nifurtimox, including adverse effects, long treatment period and stil...
Furoxan derivatives with antimalarial activity that disrupt P. falciparum endoplasmic reticulum calcium homeostasis [0.03%]
一类新型硝酮抗疟衍生物及其扰疟原虫内质网钙离子稳态的作用机制研究
Leandro da Costa Clementino,Paula J Bartlett,Guilherme F S Fernandes et al.
Leandro da Costa Clementino et al.
Malaria, caused by Plasmodium spp. parasites, presents treatment challenges due to the emergence of resistant strains to frontline antimalarials. In this study, we explored activities of 24 furoxan derivatives, originally designed for leish...
Unpacking boxes: identification of novel inhibitors of malaria parasite invasion [0.03%]
拆箱行动：疟原虫入侵抑制剂的鉴定
Claudia Bg Barnes,Molly Parkyn Schneider,Olivia D Ventura et al.
Claudia Bg Barnes et al.
With resistance to current frontline antimalarial treatments rapidly emerging in malaria endemic regions, there is an urgent need to identify new antimalarial compounds with novel mechanisms of action. Currently, no clinically used antimala...