Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei [0.03%]
改用氯霉素和克林霉素联合治疗小鼠疟疾(伯氏疟原虫)的疗效研究
Leah A Walker,Vision Bagonza,Bryce Bobb et al.
Leah A Walker et al.
Fosmidomycin and clindamycin target the Plasmodium apicoplast. Combination clinical trials have produced mixed results with the primary problem being the recrudescent infection frequency by day 28. Given that antibiotic efficacy against bac...
The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis [0.03%]
二核环状双 pallada CP2 目标泛醌细胞色素 C 还原酶（复合体 III）莱什曼原虫亚马逊式
Angela Maria Arenas Velásquez,Irwin Alexander Patino Linares,Lawrence D Gaspers et al.
Angela Maria Arenas Velásquez et al.
Leishmaniasis is a neglected disease that remains with a limited number of drugs available for chemotherapy and has an increased drug resistance that affects treatment outcomes. Metal-based drugs such as cyclopalladated complex [Pd(dmba)(μ...
Lactoferrin-modified nanoemulsions enhance brain-targeting and therapeutic efficacy of arctigenin against Toxoplasma gondii-induced neuronal injury [0.03%]
乳铁蛋白修饰的纳米乳液可增强斑鸠菊素针对刚地弓形虫感染诱导的神经元损伤的治疗效果
Jing-Mei Lu,Guang-Nan Jin,Yan Xin et al.
Jing-Mei Lu et al.
Toxoplasma gondii, a neurotropic protozoan parasite, affects the central nervous system and causes various neurological disorders. Previous studies have demonstrated that Arctigenin (AG) exhibits anti-T. gondii activity and reduces depressi...
Licochalcone a: A promising antiparasitic drug against giardiasis [0.03%]
寄生虫病防治的潜力药物：Licochalcone a抗氧化抗寄生虫作用研究
Yingying Zhang,Wenchao Zhao,Haili Du et al.
Yingying Zhang et al.
Giardiasis, caused by Giardia duodenalis, is a prevalent and significant zoonotic disease. While nitroimidazole drugs are primarily used to treat giardiasis, the urgent need for the development and formulation of new drugs has arisen due to...
Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment [0.03%]
番倍哒唑对抗莫桑比克马普托省自然感染 goats 肠道线虫的体内、体外和分子评价效力研究
Edna F X Guinda,Sonia M S Afonso,Stefan Fiedler et al.
Edna F X Guinda et al.
Anthelmintic resistance occurs worldwide in strongyles of ruminants but data from low-income countries are sparse and rarely apply most up to date methods, while effects of management practices in these countries are poorly documented. In M...
Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection [0.03%]
依卜帕索穆草精油及其主要化合物单独或与葡萄糖宁联合对抗利什曼原虫感染的抗利什曼病和协同作用效应
Abdullah D Alanazi,Areej Jameel Alghabban
Abdullah D Alanazi
Cutaneous leishmaniasis (CL) is a widespread disease affecting both humans and animals globally. Currently, common treatments (e.g., glucantime (GC) for CL treatment have many side effects that limit their use. The current experimental stud...
Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment [0.03%]
阿苯达唑治疗前后 whipple氏钻异虫完整β微管蛋白基因的深度扩增子测序
Javier Gandasegui,Berta Grau-Pujol,Valdemiro Novela et al.
Javier Gandasegui et al.
Concerns about the emergence of benzimidazole resistance in soil-transmitted helminths (STH) infections, particularly against Trichuris trichiura, have arisen. Previous studies of veterinary nematodes have linked benzimidazole resistance to...
Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo [0.03%]
民主刚果布拉柴维尔南部地区恶性疟原虫对磺胺多辛-甲氧苄啶抗药性的分子标记特征分析
Jean Claude Djontu,Marcel Tapsou Baina,Jacque Dollon Mbama Ntabi et al.
Jean Claude Djontu et al.
Background: Although the seasonal and perennial malaria chemopreventions are not implemented in the Republic of Congo, resistance to Sulfadoxine-pyrimethamine (SP) threatens the intermittent preventive treatment during pr...
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a [0.03%]
基于CRISPR/Cas12a的巢氏 PCR 和重组酶扩增技术在恶性疟原虫疑似quine耐药基因E415G-exo快速检测中的应用研究
Huiyin Zhu,Daiqian Zhu,Yuting Li et al.
Huiyin Zhu et al.
Malaria remains a major public health concern. The rapid spread of resistance to antimalarial drugs is a major challenge for malaria eradication. Timely and accurate molecular monitoring based on practical detection methods is a critical st...
Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs [0.03%]
基于酵母的检测疟原虫钠磷酸盐摄取转运蛋白抑制剂以开发新型抗疟药物的方法
Joseph M Sweeney,Ian M Willis,Myles H Akabas
Joseph M Sweeney
Malaria affects almost 250 million people annually and continues to be a significant threat to global public health. Infection with protozoan parasites from the genus Plasmodium causes malaria. The primary treatment for malaria is artemisin...