Identification of new Trypanosoma cruzi-specific protein synthesis inhibitors by using a developed high-throughput in vitro translation assay [0.03%]
一种用于鉴定新的克氏锥虫特异性蛋白质合成抑制剂的高效体外翻译系统及其应用
Camila Colombari Mantovani,Flavia R Novais Freitas,Carolina Borsoi Moraes et al.
Camila Colombari Mantovani et al.
There are restricted treatment options for Chagas disease, a global health risk causing 12,000 fatalities annually. This situation is exacerbated by environmental changes and migration, which is altering patterns of disease transmission, an...
Discovery of thienopyrimidine analog G-18 as a novel anti-trichomonal agent [0.03%]
新型抗滴虫剂噻二吡啶类似物G-18的发现
Yao Zhang,Bingqian Zhang,Daiqian Zhu et al.
Yao Zhang et al.
Trichomoniasis, caused by Trichomonas vaginalis, is the most prevalent nonviral sexually transmitted infection worldwide. The occurrence of treatment failure with metronidazole (MTZ) and the adverse effects of currently available nitroimida...
Evolutionary diversity of the pfmdr1 hinge region and association with antimalarial drug resistance mutations post ACT introduction [0.03%]
青蒿素联合疗法引入后的pfmdr1铰链区进化多样性及其与抗疟药物耐药突变的关联分析
Emma Filtenborg Hocke,Helle Hansson,Ana Chopo-Pizarro et al.
Emma Filtenborg Hocke et al.
The Plasmodium falciparum multidrug resistance-1 (pfmdr1) gene, which encodes the ABC P-glycoprotein homolog PgH1, accumulates mutations that result in amino acid changes, namely single-nucleotide polymorphisms at codons N86Y, Y184F, and D1...
Histone deacetylase inhibitors enhance the amoebicidal activity of amphotericin B against Naegleria fowleri [0.03%]
组蛋白去乙酰酶抑制剂可增强棘阿米巴感染的肺孢子菌刚地芽胞杆菌抗菌活性
Hae-Ahm Lee,Hye-Jeong Jo,Ji-Youn Hong et al.
Hae-Ahm Lee et al.
Naegleria fowleri is a free-living amoeba that causes a rare but almost always fatal brain infection known as primary amoebic meningoencephalitis (PAM). Although amphotericin B (AmB) is considered the primary treatment for PAM, it is often ...
Three-year evaluation of anthelmintic treatment efficacy against equine strongyles in France using FECRT [0.03%]
法国马圆线虫病粪便检查减虫效药三年评估研究（FECRT）
Gabin Brucelle,Marie Delerue,Kenza Bourrier et al.
Gabin Brucelle et al.
Reduced anthelmintic efficacy against strongyles in equids is a widespread concern, but up-to-date field data are scarce. The aim of this study was to evaluate, over a three-year period, the efficacy of the anthelmintic (AH) molecules avail...
Mitomycin C potentiates metronidazole activity in resistant Trichomonas vaginalis through suppression of thioredoxin reductase [0.03%]
丝裂霉素C通过抑制硫氧还蛋白还原酶增强甲硝唑对耐药阴道毛滴虫的作用
Yuan-Ming Yeh,Po-Jung Huang,Yu-Lo Wu et al.
Yuan-Ming Yeh et al.
Metronidazole (MTZ) remains the first-line therapy for trichomoniasis; however, increasing resistance in Trichomonas vaginalis threatens treatment efficacy. Because iron availability enhances MTZ sensitivity, we investigated whether MTZ-ind...
Impact of cyst maturity on drug resistance assays in Acanthamoeba Genotype T4 [0.03%]
囊肿成熟度对棘阿米巴基因型T4药物抵抗性试验的影响
Chun-Hsien Chen,Ya-Na Wu,Chih Ming Tsai et al.
Chun-Hsien Chen et al.
Therapeutic failure in Acanthamoeba Keratitis (AK) is largely driven by the high resistance of cysts to antimicrobial agents. However, the development of effective cysticidal drugs is hindered by the lack of standardized in vitro encystatio...
Declining effectiveness of major anthelmintic groups against gastrointestinal nematodes of farmed ruminants in Africa based on faecal egg count reduction: systematic review and first meta-analysis [0.03%]
基于粪便虫卵减少量的系统评价和首次荟萃分析：非洲放牧反刍动物胃肠蠕虫对主要抗蠕虫药群疗效下降
E F X Guinda,S M S Afonso,J Krücken et al.
E F X Guinda et al.
Objectives: Anthelmintic resistance (AR) in gastrointestinal nematode (GIN) parasites of ruminant livestock has been widely reported in Africa but analysis of variation between regions and over time is lacking. The object...
High-throughput phenotypic screening identifies novel antimalarial scaffolds and target-associated chemotypes [0.03%]
高效筛选发现新型抗疟药物骨架和与靶点相关的化学类型
Japheth Kibet Ng&#x;etich,Normalita Eka Pravitasari,Takeshi Ishikawa et al.
Japheth Kibet Ng&#x;etich et al.
The emergence and spread of artemisinin-resistant Plasmodium falciparum threaten recent progress in malaria control and highlight the urgent need for antimalarial agents with new mechanisms of action. Here, we performed a high-throughput ph...
Activity of octyl gallate against drug-sensitive and buparvaquone-resistant Theileria annulata [0.03%]
辛基没食子酸对红虫属立克次体敏感株和贝帕奎酮耐药株的作用效果
Jin Che,Yixuan Wu,Yikang Chen et al.
Jin Che et al.
Theileria annulata, the causative agent of tropical theileriosis, poses a significant threat to cattle industries, a challenge further intensified by increasing drug resistance. In this study, the food-grade phenolic compound octyl gallate ...