MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection [0.03%]
D88信号传导诱导髓系细胞在西尼罗病毒感染后的胃肠损伤和全身性炎症反应
Shih-Ching Lin,Fang R Zhao,Matthias Mack et al.
Shih-Ching Lin et al.
Humans with autoantibodies to type I interferons (IFNs) are at higher risk for neurological disease after West Nile virus (WNV) infection. IFN signaling deficient WNV-infected mice develop greater inflammation in the brain, which correlates...
From comparative connectomics to large-scale working memory modeling in macaque and marmoset [0.03%]
从比较连接组学到猕猴和狨猴的大规模工作记忆建模
Loïc Magrou,Panagiota Theodoni,Amy F T Arnsten et al.
Loïc Magrou et al.
Although macaques and marmosets are both primates of choice for studying the brain mechanisms of cognition, they differ in key aspects of anatomy and behavior. Interestingly, a recent connectomic analysis revealed that strong top-down proje...
Efficient coding in working memory is adapted to the structure of the environment [0.03%]
工作记忆的高效编码与环境结构相适应
Qiaoli Huang,Christian F Doeller
Qiaoli Huang
Working memory (WM) relies on efficient coding strategies to overcome its limited capacity, yet how the brain adaptively organizes WM representations to maximize coding efficiency based on environmental structure remains largely unknown. In...
NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease [0.03%]
NNMT抑制可对抗慢性肾脏病早期阶段的管状细胞衰老和纤维化现象
Lucie Chanvillard,Hildo C Lantermans,Christopher Wall et al.
Lucie Chanvillard et al.
Chronic kidney disease (CKD) is projected to become the fifth leading cause of mortality by 2040. Tubular senescence drives kidney fibrosis, but current treatments do not target senescent cells. Here, we identify nicotinamide-N-methyltransf...
Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1 [0.03%]
人源器官体肿瘤移植识别出由PTPRZ1介导的胶质母细胞瘤微环境功能交流
Weihong Ge,Ryan L Kan,Can Yilgor et al.
Weihong Ge et al.
Glioblastoma is the most aggressive and deadly form of brain cancer. Here, we leverage our human organoid tumor transplantation (HOTT) co-culture system to explore how extrinsic cues modulate glioblastoma cell types and behavior. HOTT recap...
Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity [0.03%]
组织特异性限制转座子衍生的调控元件以保护细胞类型身份
Danica Milovanović,Julien Duc,Wayo Matsushima et al.
Danica Milovanović et al.
Transposable elements (TEs) reshape mammalian cis-regulatory landscapes, but the mechanisms controlling their context-specific activity remain unclear. KRAB zinc finger proteins (KZFPs) typically repress TE-derived regulatory activity via T...
Prenatal glucocorticoids exposure disrupts maturation of a cluster of microglia, causing poor social memory and more repetitive behaviors [0.03%]
孕期糖皮质激素暴露破坏小胶质细胞群的成熟，导致社交记忆减退和重复行为增多
Baixiu Zheng,Ning Zhang,Meng Hu et al.
Baixiu Zheng et al.
Prenatal glucocorticoid exposure is associated with higher risks of autism spectrum disorder (ASD), yet the underlying mechanisms remain poorly understood. Here, we report that late-pregnancy exposure to dexamethasone (a synthetic glucocort...
Unveiling the neuroprotective power of mitochondrial transfer in orofacial inflammatory pain through ER membrane remodeling [0.03%]
通过内质网膜重塑揭示口腔颌面部炎症痛中线粒体转移的神经保护作用
Chen Li,Yike Li,Fei Liu et al.
Chen Li et al.
Neuro-glial mitochondrial transfer critically sustains neuronal function in disease. While this transfer reshapes inflammatory microenvironments, its pathological mechanisms in peripheral inflammatory pain remain uncharacterized, impeding t...
Zombosomes are anucleated cell couriers that spread α-synuclein pathology [0.03%]
无核细胞递送载α-突触核蛋白病理性颗粒——“僵尸体”
Abdulkhalek Dakhel,Chiara Beretta,Tobias Mothes et al.
Abdulkhalek Dakhel et al.
Astrocytes not only play a central role in orchestrating the brain's microenvironment but also are tightly connected to neurodegenerative processes. Hence, unraveling astrocytes' intercellular pathways can give important insight into diseas...
Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity [0.03%]
乳酸转运抑制剂诱导的乳酰化核RIG-I通过抑制PARP1活性抑制DNA损伤修复
Yulin Li,Chao Wang,Siru Zhou et al.
Yulin Li et al.
RIG-I (DDX58) is typically localized in the cytoplasm and activates innate immunity. However, the mechanisms governing its nuclear translocation and functions remain incompletely understood. Here, we discover that RIG-I undergoes lactylatio...