Activation of nuclear Ca2+-dependent gene expression by CRAC channel Ca2+ nanodomains [0.03%]
通过CRAC通道钙纳米域激活核内Ca2+依赖性基因表达
Yu-Ping Lin,Abdull J Massri,Yi-Ting Huang et al.
Yu-Ping Lin et al.
Oscillations in the levels of second messengers are observed throughout the phylogenetic tree, with signaling information encoded in the frequency of the spikes. Different biological targets respond to different frequencies of oscillation, ...
Cancer-associated fibroblast-derived extracellular vesicles deliver ATP6V1C1 to promote lung adenocarcinoma metastasis via the ID1-IGFBP3 axis [0.03%]
癌相关成纤维细胞衍生的胞外囊泡通过ID1-IGFBP3轴递送ATP6V1C1促进肺腺癌转移
Xuanming Chen,Jue Li,Cheng Shen et al.
Xuanming Chen et al.
Cancer-associated fibroblast (CAF)-derived extracellular vesicles (EVs) mediate lung adenocarcinoma (LUAD) progression, but the role of their protein cargo remains poorly defined. Through quantitative proteomic profiling of EVs from patient...
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks [0.03%]
JNK通过募集PARP1到DNA断裂处磷酸化SIRT6以响应氧化应激刺激DNA双链修复
Michael Van Meter,Matthew Simon,Gregory Tombline et al.
Michael Van Meter et al.
Published Erratum
Cell reports. 2026 Jan 17;45(1):116960. DOI:10.1016/j.celrep.2026.116960 2026
Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors [0.03%]
昆虫唾液效应子破坏PIEZO1轴心的机械免疫以抵御刺吸式害虫
Xiande Huang,Kaixing Gao,Pingzhi Zhao et al.
Xiande Huang et al.
Hosts deploy mechanosensory systems to intercept herbivory threats, yet how plants decode insect-derived mechanical force remains unclear. Here, we demonstrate that PIEZO-type mechanosensitive ion channel component 1 (PIEZO1) serves as a me...
Stuxnet balances mitochondria homeostasis by regulating uhg5 and parkin [0.03%]
Stuxnet通过调控uhg5和parkin平衡线粒体稳态
Xianguo Zhao,Xingzhuo Yang,Yuansheng Huang et al.
Xianguo Zhao et al.
Emerging evidence implicates the Stuxnet (Stx) protein in human disease, extending beyond its known role in proteasome-independent degradation. Exploring this further, our investigation into stx downstream targets in Drosophila reveals that...
Neurotransmission-modulated whole-brain computation captures full task repertoire [0.03%]
受神经传递素调制的全脑计算捕获了完整的任务组合模式
Gustavo Deco,Yonatan Sanz Perl,Jakub Vohryzek et al.
Gustavo Deco et al.
An important unsolved problem is how the brain survives in a complex world by performing a rich repertoire of computation on a minimal energy budget. Despite using a seemingly fixed architecture, the brain performs much better than current ...
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice [0.03%]
在PS19雄性小鼠的小胶质细胞中可诱导删除DGAT1和DGAT2加重神经退行性疾病和内溶酶体脂质积累
G Travis Tabor,Alexandra Litvinchuk,Yun Chen et al.
G Travis Tabor et al.
Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed to be contained in lipid droplets (LDs). While studies have been performed in cell culture...
Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation [0.03%]
内源性损伤和电离辐射应答情况下发现DNA修复网络中的基因互作关系
Benjamin Nebenfuehr,Lynn Sanford,Erin R Taylor et al.
Benjamin Nebenfuehr et al.
Genomic integrity relies on a complex network of DNA damage response (DDR) pathways that repair endogenous and exogenous lesions, yet how individual factors operate within this broader landscape remains unclear. We performed a large-scale c...
Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia [0.03%]
登革病毒2型和3型的基因组流行病学研究表明，在哥伦比亚反复引入和输出几种谱系
Ricardo Rivero,Vaneza Tique-Salleg,Daniel Echeverri-De la Hoz et al.
Ricardo Rivero et al.
Dengue fever, a major mosquito-borne viral disease, is transmitted by Aedes mosquitoes and poses a significant global health burden. Despite extensive research, the spatiotemporal dynamics of dengue virus (DENV) lineages in Colombia remain ...
A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila [0.03%]
组蛋白H2A和H2B点突变体库定义了果蝇体内基本功能
Angyang Sun,Yan Guo,Zilong Wei et al.
Angyang Sun et al.
Published Erratum
Cell reports. 2026 Jan 16;45(1):116959. DOI:10.1016/j.celrep.2026.116959 2026