Uncovering the "hidden" synaptic microarchitecture of the retinal direction selective circuit [0.03%]
揭示视网膜方向选择回路的“隐藏”突触微环路结构
Geoff deRosenroll,Santhosh Sethuramanujam,Gautam B Awatramani
Geoff deRosenroll
GABAergic/cholinergic starburst amacrine cells play a crucial role in shaping direction selectivity in the dendrites of downstream direction-selective (DS) ganglion cells (DSGCs) in the retina by providing "null" inhibitory and "preferred" ...
Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity [0.03%]
靶向ZDHHC12介导的PARP1棕榈酰化可增强PARP抑制剂细胞毒性的研究
Xining Zhang,Ye Liu,Xingming Liao et al.
Xining Zhang et al.
Poly(ADP-ribose) polymerase inhibitors (PARPi) elicit cytotoxicity by trapping PARP1 at DNA lesions, but clinical resistance remains a major challenge. Here, we identify reversible S-palmitoylation as a negative regulator of PARP1 chromatin...
A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells [0.03%]
Jagged1调节的混合型上皮间质转化状态识别胰腺癌干细胞
Linxiang Lan,Huafu Li,Shiwei Zhang et al.
Linxiang Lan et al.
Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations. We previously identified a PDAC subpopulation, marked by the tetraspanin CD9, which is capable o...
A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types [0.03%]
室旁核细胞类型的时空转录组图谱
Yuxi Li,Trevor C Butler,Stefano Nardone et al.
Yuxi Li et al.
The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron po...
C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen [0.03%]
C9orf72在髓系细胞中可防止对微生物糖原的炎症反应
Blake McCourt,Katelyn Lemr,Shinjon Chakrabarti et al.
Blake McCourt et al.
Gut dysbiosis and neural inflammation occur in patients with amyotrophic lateral sclerosis (ALS), including those with a causal mutation in chromosome 9 open reading frame 72 (C9ORF72). How gut commensals interact with common ALS genotypes ...
SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity [0.03%]
SREBP-1通过防止脂毒性上调SOAT1以促进肿瘤生长
Yaogang Zhong,Logan Mazik,Huali Su et al.
Yaogang Zhong et al.
Rapidly growing tumors require abundant supplies of cholesterol, but excess cholesterol can be cytotoxic. How cancer cells balance this demand while avoiding lipotoxicity remains unclear. Our study found that SOAT1, the enzyme that converts...
A shear stress-responsive pathway in monocytes drives cardiopulmonary bypass-induced inflammation via spectrin/RAF1/store-operated calcium entry [0.03%]
单核细胞中的剪切应力反应通路通过spectrin/RAF1/SOCE介导体外循环诱导的炎症反应
Weiming Li,Lan N Tu,Lance Hsieh et al.
Weiming Li et al.
Cardiopulmonary bypass (CPB) during cardiac surgery triggers inflammation that increases morbidity and mortality, though its molecular mechanisms remain unknown. To address this gap, we conducted single-nucleus RNA/ATAC sequencing (snRNA-se...
SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring [0.03%]
SNAP-25疾病变异通过多聚体SNARE环内的不稳定性影响突触传递
Victoria Amstrup Vold,Jie Yang,Maiken Østergaard et al.
Victoria Amstrup Vold et al.
SNAREopathies are neurodevelopmental syndromes arising from de novo mutations in the synaptic machinery. Two variants are SNAP-25 I192N and I192T, which cause early lethality and moderate developmental delay, respectively. Both variants lea...
NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin [0.03%]
NuMA通过稳定染色质上的连接组蛋白H1促进构成性异染色质凝聚
Yao Wang,Wenxue Zhao,Jiahao Niu et al.
Yao Wang et al.
Heterochromatin exerts pivotal functions of silencing specific genes and maintenance of genome stability. However, its formation and maintenance mechanisms remain unclear. Here, we discover that the mitotic regulator NuMA, as a nucleoskelet...
Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate [0.03%]
解析人类未分化精原细胞的异质性揭示了RAS依赖性的干细胞命运调节机制
Chiara Capponi,Christopher Smith,Alexa Medica et al.
Chiara Capponi et al.
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and hold therapeutic potential for treating male infertility. While rodent SSCs are well characterized, human SSCs remain poorly understood. Here, we screen antibo...