METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy [0.03%]
成纤维细胞中METTL3/CD98介导的谷氨酸释放通过促使CD8+T细胞衰竭妨碍新辅助免疫化疗的效果
Chunyu Feng,Su-Ran Li,Xiaoshuai Xu et al.
Chunyu Feng et al.
The role of neurotransmitters in suppressing anti-tumor immunity has garnered increasing attention. While glutamate has been extensively studied in neurological diseases, its potential role in regulating anti-tumor immunity, particularly in...
Immunoglobulin A-producing cells mediate the clinical benefits of metformin via interleukin-10 [0.03%]
通过白细胞介素-10介导的作用代谢药物二甲双胍的临床疗效免疫球蛋白A生成细胞
Jielong Guo,Xue Han,Yue Qin et al.
Jielong Guo et al.
Metformin (MTF) is the primary treatment for type 2 diabetes, but its mechanisms for enhancing insulin sensitivity require thorough exploration. This study revealed that MTF improves insulin sensitivity by promoting the proliferation and tr...
α-Ketoglutarate couples cellular metabolism to developmental growth via hydroxylation-dependent degradation of Yorkie [0.03%]
α-酮戊二酸通过羟基化依赖性降解Yorkie将细胞代谢与发育生长相结合
Tao He,Yongchang Zeng,Jie Zhou et al.
Tao He et al.
The evolutionarily conserved Hippo signaling pathway, essential for development and tissue homeostasis, is intimately linked to cellular metabolism. While cellular α-ketoglutarate (α-KG) levels fluctuate with metabolic state, the function...
Ccl12 coordinates immune-neural crosstalk to promote adipose sympathetic remodeling after burn trauma [0.03%]
烧伤创伤后Ccl12协调免疫-神经交叉 talk促进脂肪组织交感神经重塑
Chuwei Zhang,Yanshen Chen,Jingya Guo et al.
Chuwei Zhang et al.
Burn injury triggers sustained white adipose tissue (WAT) remodeling and hypermetabolism. While systemic catecholamines are considered primary drivers of this response, local mechanisms remain poorly defined. Here, we identify an intra-fat ...
Potential for microbial methanethiol-dependent dimethylsulfide production in different marine sediments [0.03%]
不同海洋沉积物中微生物甲基硫醇依赖型二甲硫的产生能力研究进展
Zihua Guo,Haojin Cheng,Hai Shi et al.
Zihua Guo et al.
Dimethyl sulfide (DMS) plays a pivotal role in sulfur cycling and climate regulation. This study investigates microbial DMS production via the methylation of hydrogen sulfide (H2S) and methanethiol (MeSH) in nearshore, pelagic deep-sea, and...
Cross-disease analysis identifies the inflammatome as a transcriptional program of inflammation [0.03%]
跨疾病分析识别炎症转录程序的炎性因子组分
Isabel Díaz-Pinés Cort,Oana Palasca,Luca Finn Gaessler et al.
Isabel Díaz-Pinés Cort et al.
Inflammation is a complex biological process that upregulates numerous genes compared to homeostasis. These transcriptional changes can dominate the statistical signal in differential expression analyses and confound the detection of diseas...
Purifying selection on deleterious variants affected by the combination of subgenomes and gene expression in bread wheat [0.03%]
小麦不良变异受亚基因组和基因表达影响的纯化选择
Gwyneth Halstead-Nussloch,Moeko Okada,Georg Haberer et al.
Gwyneth Halstead-Nussloch et al.
The genome-wide pattern of purifying selection on deleterious variants has attracted broad interest in breeding and evolutionary biology. Little is known about purifying selection in polyploid species with potential functional redundancy of...
Oncogenic influences of neurotrophin receptors: Shedding light on Trk biology [0.03%]
神经营养因子受体致癌作用：照亮Trk生物学的新视野
Hawa L Jagana,Maryam M Shabar,Taylor S Jackson et al.
Hawa L Jagana et al.
During critical stages of neurodevelopment, tropomyosin receptor kinase receptors, encoded by NTRK genes, exhibit temporally driven differential peaks of expression to properly guide the establishment of the peripheral and central nervous s...
Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH [0.03%]
MASH模型中血管内皮-库普弗细胞互作驱动瘢痕修复期肝纤维化-resolution阶段发生机制的研究
Kenneth Li,Vardhman Kumar,Tran To et al.
Kenneth Li et al.
Fibrosis contributes to ∼40% of mortality in the industrialized world. Fibrosis in the liver can spontaneously resolve when injury terminates. In this study, we establish a robust mouse model of fibrosis regression in MASH (metabolic dysfu...
Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS [0.03%]
二聚体依赖的类似凝胶状的dsDNA凝聚诱导人类cGAS活化
Jacob Lueck,Alexander Strom,Stephanie Martinez Torres et al.
Jacob Lueck et al.
Cyclic G/AMP (cGAMP) synthase (cGAS) initiates inflammatory responses against pathogenic double-stranded (ds)DNA. Although it is well established that cGAS forms phase-separated condensates with dsDNA, its function remains poorly defined. W...