Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity [0.03%]
小鼠背部主动脉中通过不同的Runx1+110增强子活性区分血液干细胞与祖细胞的潜能
Giorgio Anselmi,Vincent Frontera,Christina Rode et al.
Giorgio Anselmi et al.
Hematopoietic stem cells (HSCs) are important in cell-based therapies for blood-related disorders. While progress has been made in generating HSCs by directed differentiation of pluripotent stem cells (PSCs), such cultures promote hematopoi...
Defining a subclass of cerebellar molecular layer interneurons by their Purkinje cell feedback [0.03%]
一种小脑分子层中间神经元亚型及其与浦肯野细胞的反馈联系
Jinsook Kim,George J Augustine
Jinsook Kim
A subset of molecular layer interneurons (MLIs), previously termed Purkinje cell-input MLIs (PC-MLIs), receive inhibitory feedback from Purkinje cells (PCs), the sole output neurons of the cerebellar cortex. Here we have characterized the p...
CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion [0.03%]
利用CRISPR活化筛选鉴定MARCKSL1为细胞外囊泡释放的标记物
Yingjie Zhong,Anna E George,Roman I Koning et al.
Yingjie Zhong et al.
Extracellular vesicles (EVs) are central mediators of intercellular communication that originate from diverse membrane reservoirs. EV biogenesis can occur via multiple pathways, including outward budding of the plasma membrane (PM) and fusi...
Hypothalamic recurrent inhibition regulates functional states of stress effector neurons [0.03%]
下丘脑反复性抑制调节应激效应神经元的功能状态
Aoi Ichiyama,Samuel Mestern,Tamás Füzesi et al.
Aoi Ichiyama et al.
Corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) are essential for homeostasis and stress responses, bidirectionally shifting from low- to high-activity state. However, the circuit mechanisms g...
CXCR4 marks homeostatically activated dendritic cells in the steady state and in cancer [0.03%]
CXCR4标记稳态下和癌症中的静息状态下激活的树突状细胞
Mariana Pereira da Costa,Cécile Piot,Margarida Bonifacio et al.
Mariana Pereira da Costa et al.
Conventional dendritic cells (cDCs) can be activated by pathogen signals and inflammation to drive T cell immunity to infection, but they can also undergo "homeostatic activation" at steady state. However, homeostatically activated cDCs clo...
PLCd4 signaling-mediated PI4P synthesis drives macrophage NLRP3 inflammasome activation to promote heat stroke-induced tissue injury [0.03%]
PLcd4信号介导的PI4P合成促进巨噬细胞NLRP3炎性小体活化以促进中暑所致组织损伤
Riqing Wei,Wenqian Zheng,Chenxin Liu et al.
Riqing Wei et al.
Heat stroke causes life-threatening systemic inflammation and multiorgan injury, but the intracellular mechanisms that sustain inflammatory amplification after heat exposure remain unclear. Here, using heat stroke mouse models, genetic NLRP...
Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem [0.03%]
Hoxa2决定小鼠躯体感觉脑干中barrelette神经元的身份和连接性
Ahmad Bechara,Christophe Laumonnerie,Nathalie Vilain et al.
Ahmad Bechara et al.
Published Erratum
Cell reports. 2026 Jul 31;45(8):117798. DOI:10.1016/j.celrep.2026.117798 2026
Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division [0.03%]
有丝分裂期间的内质网-线粒体接触增强线粒体钙离子流入以促进细胞分裂
Gan Zhao,Mingkang Jia,Shicong Zhu et al.
Gan Zhao et al.
Published Erratum
Cell reports. 2026 Jul 31;45(8):117843. DOI:10.1016/j.celrep.2026.117843 2026
Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome [0.03%]
营养压力激活RAB5B介导的自噬以重塑突触蛋白组学
Melina Overhoff,Lotte Ickert,Sebastian Marten et al.
Melina Overhoff et al.
Synaptic proteostasis is crucial for neuronal function, yet how synapses adapt to metabolic stress remains unclear. We show that nutrient stress, particularly serum withdrawal, induces autophagy-dependent remodeling of the synaptic proteome...
SLC39A11 mediates intracellular manganese partitioning and adaptive iron transport [0.03%]
SLC39A11介导细胞内锰的分布和适应性铁转运
Yanmei Cui,Fan Du,Juan Wang et al.
Yanmei Cui et al.
Zrt/Irt-like protein (ZIP) family members typically mediate zinc transport into the cytoplasm. Here, we characterize SLC39A11(ZIP11)-an evolutionarily conserved ZIP homologous to Escherichia coli metal ZupT-revealing its context-dependent r...