PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function [0.03%]
PD-L1是自然杀伤细胞介导的、TRAIL依赖的抗病毒功能的内在开关
Kayla Frank,Himani Sharma,Efthymios Motakis et al.
Kayla Frank et al.
Each year, influenza A virus (IAV) infection of the lung causes half a million deaths worldwide. Patients with compromised immunity experience distinct influenza pathogenesis; however, most IAV-related research is done with wild-type mice o...
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood [0.03%]
生命早期NAD+缺乏通过持续抑制从儿童期开始的透明质酸合成程序骨骼肌衰老
Mariam Karim,Keisuke Yaku,Jun-Dal Kim et al.
Mariam Karim et al.
Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been associated with the development of aging-associated diseases. However, it remains unknown whether low NAD+ levels in early life affect aging. This study demons...
Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo [0.03%]
FN14是一个由Bmal1调控的、活化依赖型细胞因子受体，可诱导小胶质细胞向棒状表型转化并限制体内神经元活性
Austin Ferro,Dominic J Vita,Trevor Fallon et al.
Austin Ferro et al.
Cytokines and their receptors play important roles in brain development and aging-related disease, but their functions within the healthy adult brain remain poorly understood. Here, we show that pyramidal neurons in hippocampal CA1 induce F...
Systems mapping of intra-donor, cross-tissue T cell clonal expansion and tissue adaptation in the gut-liver-blood axis [0.03%]
肠道-肝脏-血液轴内供者间、跨组织T细胞克隆扩增和组织适应的系统映射
Ran Ran,Merve Uslu,Mohd Farhan Siddiqui et al.
Ran Ran et al.
The human gut-liver axis is a critical immunological interface, yet factors that shape T cell adaptation and clonal expansion across tissues remain unclear. We performed integrated single-cell RNA and T cell receptor sequencing on T cells f...
Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons [0.03%]
利用电流引导和神经元放电生成的生物物理特性进行亚细胞分辨率的电刺激
Praful K Vasireddy,Ramandeep S Vilkhu,Amrith Lotlikar et al.
Praful K Vasireddy et al.
Electrical stimulation at cellular resolution to restore the function of neural circuits is limited by the density of available electrode arrays. Although current steering with multi-electrode stimulation can be used to target cells between...
Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus [0.03%]
成人人类腹内侧和下丘脑弓核单细胞分辨率的空间解析分子性别差异
Bernard Mulvey,Yi Wang,Heena R Divecha et al.
Bernard Mulvey et al.
The hypothalamus contains multiple regions, including the ventromedial hypothalamus (VMH) and arcuate (ARC), which are responsible for sex-differentiated functions such as endocrine signaling, metabolism, and reproductive behaviors. While m...
Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques [0.03%]
在恒河猴体内诱导HIV-1对V2顶点和融合肽的中和抗体的疫苗激发作用
Hongying Duan,Joseph P Nkolola,Shuishu Wang et al.
Hongying Duan et al.
Broadly neutralizing antibodies (bNAbs) targeting multiple sites of HIV-1 Env vulnerability can be induced by infection, but simultaneous elicitation of bNAbs against multiple epitopes has not been achieved by vaccination. In this study, we...
Norepinephrine acts through radial astrocytes in the developing optic tectum to enhance threat detection and escape behavior [0.03%]
去甲肾上腺素通过发育中的顶盖光学小叶径向天疱疮细胞的作用增强威胁检测和逃跑行为
Nicholas J Benfey,Finnley Cookson,David Foubert et al.
Nicholas J Benfey et al.
The ability to switch behavioral states is essential for animals to adapt and survive. Here, we demonstrate how norepinephrine (NE) activation of radial astrocytes alters visual processing in the optic tectum (OT) of developing Xenopus laev...
Controlled pyroptosis of engineered macrophages enables biphasic antitumor via the release of oncolytic bacteria and inflammatory signals [0.03%]
工程化巨噬细胞的受控焦亡实现溶瘤细菌和炎症信号的两阶段释放抗肿瘤作用
Leyang Wu,Chenyang Li,Liyuan Qiao et al.
Leyang Wu et al.
Engineered macrophage-based therapies offer promising potential for cancer treatment but are limited by slow, uncontrolled drug release and the risk of macrophage reprogramming into tumor-promoting phenotypes. Here, we developed a thermally...
HRD1 negatively regulates autolysosome formation by inhibiting liquid-liquid phase separation of SNAP29 [0.03%]
HRD1通过抑制SNAP29的液-液相分离负向调控自噬溶酶体形成
Wenyan Qu,Di Chen,Hongyu Zhao et al.
Wenyan Qu et al.
Autophagy is a highly conserved cellular process in which cytoplasmic contents are sequestrated by autophagosomes and delivered to lysosomes for degradation. Generation of degradative autolysosomes mediated by SNARE proteins is essential; h...