Meloidogyne nematodes reprogram rhizosphere metabolism to suppress antagonistic microbiota and enable bacterial pathogen co-infection [0.03%]
根结线虫重新编程根际代谢以抑制拮抗微生物群并使细菌病原体共感染
Xu Xu,Ting Sun,Xue Qing et al.
Xu Xu et al.
Root-knot nematodes cause substantial crop losses by compromising plant immunity and facilitating invasion by soil-borne bacterial pathogens, yet the mechanisms underlying nematode-facilitated co-infection remain poorly understood. Here, we...
ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils [0.03%]
ATP7B维持的铜贮量对中性粒细胞的功能成熟是必需的
Som Dev,Yu Wang,Moonjung Jung et al.
Som Dev et al.
Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles...
SARS-CoV-2 fusion-peptide-directed antibodies are elicited by natural infection and can mediate broad sarbecovirus neutralization [0.03%]
针对 SARS-CoV-2 融合肽的抗体由自然感染引发并可介导广泛的sarbecovirus中和作用
Alex L Roederer,Chia Jung Li,Eunice Lim et al.
Alex L Roederer et al.
Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. However, the development of antibodies capable of neutral...
Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling [0.03%]
少突胶质细胞炎症激活状态决定了多发性硬化和NMOSD治疗效果悖论：IFNAR1信号传导提供新见解
Luhang Dai,Guo Cheng,Tingting Cui et al.
Luhang Dai et al.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease of the central nervous system (CNS) that, despite overlapping phenotypic features with multiple sclerosis (MS), manifests with more severe clinical out...
NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis [0.03%]
NAD+感应通过PARP7在脂肪细胞分化过程中调节C/EBPβ依赖性转录程序
MiKayla S Stokes,Yoon Jung Kim,Yonghyeon Kim et al.
MiKayla S Stokes et al.
We identified poly(ADP-ribose) polymerase 7 (PARP7), a mono(ADP-ribosyl) transferase, as a regulator of C/EBPβ-dependent proadipogenic gene expression. PARP7 functions as a nuclear NAD+ sensor; at higher nuclear NAD+ concentrations in undi...
Two-component system HprS/HprR enhances kidney colonization of uropathogenic Escherichia coli CFT073 by increasing flagellar expression [0.03%]
双组分系统HprS/HprR通过增加鞭毛表达来增强尿路致病性大肠杆菌CFT073的肾脏定植能力
Xueping Li,Yu Pang,Zixiang Liu et al.
Xueping Li et al.
Urinary tract infections (UTIs) are predominantly caused by uropathogenic Escherichia coli (UPEC) and occur via an ascending route. UPEC invades bladder epithelial cells, causing cystitis and ascends to the kidneys, inducing pyelonephritis....
Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice [0.03%]
背侧海马的神经网络在调节小鼠救援行为中的因果作用
Moisés Dos Santos Corrêa,Anna Agafonova,Ada Braun et al.
Moisés Dos Santos Corrêa et al.
Prosocial behaviors, such as rescuing individuals in need, are crucial for social cohesion across species. While key brain regions involved in rescue behavior have been identified, the underlying neural mechanisms remain unclear. The hippoc...
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity [0.03%]
FOXA1突变通过与雄激素受体合作利用新生转录因子网络来增强前列腺肿瘤的形成能力
Erik M Ladewig,Abbas Nazir,Tyler Park et al.
Erik M Ladewig et al.
Mutations in the pioneer transcription factor FOXA1 occur in 10%-40% of prostate cancers and broadly alter chromatin accessibility. In a cohort of 874 primary and metastatic tumors, we confirm frequent Wing2 missense mutations and indels, a...
Large-scale metagenomic analysis reveals host genetics shapes microbiomes in wild freshwater fish gut and skin [0.03%]
大规模宏基因组分析揭示了宿主遗传塑造淡水鱼肠道和皮肤微生物群落结构
Ruixiang Tang,Jiao Wang,Xinqi Wang et al.
Ruixiang Tang et al.
Wild freshwater fish microbiomes remain underexplored despite their ecological and economic importance. Through metagenomic sequencing of 903 gut/skin samples from 121 species in southwest China, we constructed the Wild Freshwater Fish Micr...
A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2 [0.03%]
MEK-ERK信号通过转录调节Nmnat2在神经元亚型特异的轴突存活中的作用
Wenkai Yue,Zhebin Wu,Kai Zhang et al.
Wenkai Yue et al.
Axon degeneration is a key pathological feature in neural injuries and neurological disorders. MEK1/2 inhibitors (MEKis) are used in cancer therapy but can cause peripheral nerve lesions. Paradoxically, they are being considered for neurode...