Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome [0.03%]
肝细胞PLAGL2缺乏通过MYD88许可的炎性体失活来缓解MASH
Ran Duan,Xinyi Wang,Qi Wang et al.
Ran Duan et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a pressing global health concern. The transition to metabolic dysfunction-associated steatohepatitis (MASH) is characterized by pyroptosis-driven inflammation. However, the...
Xiuxiu Lu,Vasty Osei-Amponsa,Germán Michelis et al.
Xiuxiu Lu et al.
Regulated proteolysis in eukaryotes relies on the ubiquitin-proteasome system, which is critical to myriad cellular functions, including protein quality control, cell cycle regulation, and DNA repair. Here, we provide evidence that proteaso...
Feedback control of random networks as a model of flexible motor cortical dynamics across tasks [0.03%]
随机网络的反馈控制作为跨任务灵活运动皮层动力学的一种模型
Hari Teja Kalidindi,Frédéric Crevecoeur
Hari Teja Kalidindi
Modern large-scale recordings show that motor cortex activity during reaching evolves along low-dimensional trajectories, often interpreted as neural bases for motor command generation. However, the origin of these patterns and how they fle...
CGRP signaling links tumor-associated pain to immune evasion in oral squamous cell carcinoma [0.03%]
降钙素基因相关肽信号连接口腔鳞状细胞癌相关疼痛与免疫逃避
Lisa A McIlvried,Andre A Martel Matos,Rachel S Krane et al.
Lisa A McIlvried et al.
Peripheral sensory nerves are thought to play a role in solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link between pain and immunosuppression remains unresolved. Here, we find an inverse relationship ...
High-throughput engineered tumor organoids reveal ROCK signaling as an immunotherapeutic target in triple-negative breast cancer [0.03%]
高通量工程肿瘤类器官揭示ROCK信号在三阴性乳腺癌中的免疫治疗作用
Xiaolong Zhou,Yu Zhu,George Michael Nicolas et al.
Xiaolong Zhou et al.
Triple-negative breast cancer (TNBC) remains resistant to immunotherapy because of its profoundly immunosuppressive tumor microenvironment. Here, we establish a droplet-engineered organoid (DEO) platform that preserves endogenous TILs and s...
Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination [0.03%]
缺氧缓解酸中毒引起的癌细胞转移抑制作用
Se Jong Lee,Alice Amitrano,Qinling Yuan et al.
Se Jong Lee et al.
Acidosis is a hallmark of the tumor microenvironment and has been linked to aggressive cancer behavior, characterized by increased migration, invasion, and metastasis. We herein demonstrate that short-term exposure (24-72 h) to acidic extra...
Bacterial defense systems and host ecology drive the evolution of intra-species lineages [0.03%]
细菌防御系统和宿主生态学驱动种内谱系的进化
Jamie Gorzynski,Joshua D Harling-Lee,Wendy Figueroa et al.
Jamie Gorzynski et al.
Horizontal gene transfer (HGT) is a major driver of diversity in bacterial populations. However, our understanding of its impact on the evolution of intra-species lineages is limited. The multi-host bacterial pathogen Staphylococcus aureus ...
A p63-dependent molecular switch directs epithelial fate to form a specialized seal at the tooth-gingiva interface [0.03%]
一个依赖于p63的分子开关引导上皮细胞命运形成牙齿与牙龈界面的特化密封结构
Yu Liang,Jie Gao,Litian Han et al.
Yu Liang et al.
Failure to maintain the epithelial seal at the tooth-gingiva interface drives periodontitis. This specialized junctional epithelium (JE) is critical for immune homeostasis, yet mechanisms for its regeneration are poorly understood. Using mu...
A bicistronic viral genome uses a compact type IV IRES near its 3' end to express a transmembrane protein [0.03%]
一种双顺反子病毒基因组利用一个紧靠其3'端的紧凑型IV类IRES表达跨膜蛋白
Madeline E Sherlock,Katherine E Segar,Jeffrey S Kieft
Madeline E Sherlock
Hepatitis C virus (HCV) and many other RNA viruses contain a type IV internal ribosome entry site (IRES) in their 5' untranslated region (UTR). These IRES RNAs interact directly with the ribosome, enabling cap-independent translation initia...
Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models [0.03%]
昼夜节律异质性调节神经母细胞瘤模型的药物反应变异
Carolin Ector,Christoph Schmal,Jeff Didier et al.
Carolin Ector et al.
Circadian clocks regulate essential cellular functions and influence cancer development and treatment outcomes. Aligning therapy with circadian rhythms can improve efficacy and reduce toxicity, yet whether neuroblastoma, a heterogeneous ped...