NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma [0.03%]
NF1功能丧失在胰腺导管腺癌中的作用
Gopalakrishnan Ramakrishnan,Parash Parajuli,Pura Singh et al.
Gopalakrishnan Ramakrishnan et al.
Published Erratum
Cell reports. 2026 Feb 14;45(2):117066. DOI:10.1016/j.celrep.2026.117066 2026
Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation [0.03%]
EphB4的液-液相分离通过YAP活化驱动肺动脉高压
Jia-Yu Liu,Jing Chen,Qin-Ye Chen et al.
Jia-Yu Liu et al.
Vascular extracellular matrix stiffening is an early and pervasive driver of pulmonary hypertension (PH), though its mechanistic links to pathological cellular responses remain unclear. This study identifies Eph receptor B4 (EphB4), a recep...
Paula Abou Karam,Edo Kiper,Tamar Ziv et al.
Paula Abou Karam et al.
Eukaryotic pathogens deploy diverse strategies to manipulate host immunity, yet RNA-based virulence mechanisms remain poorly understood. We describe a mechanism by which the malaria parasite Plasmodiumfalciparum governs host immune response...
Tong Ye,Ivan Jakovlić,Zixu Chen et al.
Tong Ye et al.
Cyanobacteria dominate the foundational biological soil crusts (biocrusts) of hypersaline deserts, but how they adapt to extreme hypersaline environments remains a fundamental question. Here, we assemble the genome and investigate the adapt...
Pathogen effector disarms circadian-immune crosstalk by targeting TCP14, a dual regulator of clock and defense [0.03%]
病原体效应子通过靶向TCP14削弱生物钟-免疫互作
Yu Wang,Jiayue Wu,Xuan Cui et al.
Yu Wang et al.
Pathogens across kingdoms converge on hijacking plant immune hubs, but why certain host proteins emerge as evolutionary "hotspots" remains elusive. Here, we reveal that the transcription factor TCP14, a prime effector target, serves as a ci...
Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function [0.03%]
单细胞多组学分析强调NKX2.2-CLEC16A/胞内体途径在人类胰腺分化和功能中的核心作用
Guo Chen,Xiaojie Ma,Liling Jiang et al.
Guo Chen et al.
Investigating the gene regulatory programs directing stem cell differentiation can provide new insights into cell fate decision. Recently, we have developed an expandable pancreatic progenitor (ePP) platform, but the detailed characterizati...
Toxoplasma gondii infection misdirects placental trophoblast lineage specification [0.03%]
弓形虫感染干扰胎盘滋养细胞谱系分化方向
Leah F Cabo,Liheng Yang,Mingze Gao et al.
Leah F Cabo et al.
Pregnancy is a critical point of vulnerability to pathogen infection. The placenta is a protective and nutrient-permeable barrier to most infectious agents, but a few can bypass its defenses. Little is known about how exposure to these path...
Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities [0.03%]
自然状态下S.cerevisiae的 quantitative遗传学在交配时揭示了适应性传承决定因子和不同交配亲和力
Sivan Kaminski Strauss,Ruthie Golomb,Donya Khoury et al.
Sivan Kaminski Strauss et al.
Among the fundamental questions in sexual reproduction are how fitness is inherited and whether parents exhibit differential mating affinities. Addressing these questions requires quantitative genetic tools and large phenotyped and genotype...
In vivo modeling of human γδ T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 Vδ2 T cell development [0.03%]
体内人γδ T细胞发育谱系的建模表明末端脱氧核糖核酸转移酶是III型Vδ2 T细胞发育的关键调节因子
Céline La,Aurélie Detavernier,Maria Papadopoulou et al.
Céline La et al.
Profound differences in T cell receptor (TCR) repertoire and functional profiles between human and murine γδ T cells pose significant challenges for translational γδ T cell research. Therefore, we generated humanized immune system (HIS)...
Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability [0.03%]
全面的透明细胞肾细胞癌表观基因组图谱的绘制为肾癌的发生进展及遗传性提供信息
Sarah Abou Alaiwi,Elio Adib,Ziwei Zhang et al.
Sarah Abou Alaiwi et al.
By generating 194 epigenomic and transcriptomic datasets from 57 human tissue samples using H3K27ac and HIF2α chromatin immunoprecipitation sequencing (ChIP-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq), and ...