Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation [0.03%]
识别子宫内膜中对Treg细胞积累和着床必不可少的CD169+巨噬细胞
Takuto Ohki,Shingo Miyawaki,Tsunaki Higa et al.
Takuto Ohki et al.
Successful pregnancy requires coordinated regulation between the innate and adaptive immune systems. Regulatory T (Treg) cells are essential for establishing maternal immune tolerance to the semi-allogeneic fetus, but the innate immune cell...
PCIF1-mediated m6Am modification in ACC neurons participates in inflammatory pain and anxiety [0.03%]
ACC神经元中的PCIF1介导的m6Am修饰参与炎症痛和焦虑反应
Ya Liu,Yue Huang,Keqing Xue et al.
Ya Liu et al.
N6,2'-O-dimethyladenosine (m6Am) modification, mediated by the methyltransferase phosphorylated CTD interacting factor 1 (PCIF1), is increasingly recognized as an important layer of gene regulation. However, the role of m6Am in pain and com...
Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity [0.03%]
USP39通过稳定PB2和调控核蛋白复合物组装驱动H5型流感病毒的复制和致病性
Hui Yang,Yurui Dong,Ying Bian et al.
Hui Yang et al.
Host cells combat avian influenza virus (AIV) infection by targeting viral polymerase PB2 for degradation, yet how the virus counteracts this remains elusive. In this study, we analyze the host proteins interacting with H5 AIV PB2 and ident...
Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres [0.03%]
局部异染色质富集促进端粒聚集和PML核体在端粒处组装
Erin R Taylor,Bruce Proctor rd,Melina Vaurs et al.
Erin R Taylor et al.
The alternative lengthening of telomeres (ALT) pathway is a recombination-based telomere maintenance mechanism used by a subset of human cancers and is characterized by telomere clustering within telomere-associated promyelocytic leukemia (...
ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia [0.03%]
ACSL4关联的脂质代谢是KMT2A重排急性髓系白血病的独特治疗脆弱性
Silvia Schäfer,Elahe Rahimian,Lola Schmitz-Hübsch et al.
Silvia Schäfer et al.
Deregulated lipid metabolism contributes to leukemogenesis and the progression of acute myeloid leukemia (AML). By analyzing large-scale CRISPR-Cas9 screening data, we identified acyl-CoA synthetase long-chain family member 4 (ACSL4) as a s...
Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms [0.03%]
基于胰腺神经内分泌肿瘤的蛋白质组转录组联合分类和特征鉴定
Kevin C Yang,Steve E Kalloger,John J Aird et al.
Kevin C Yang et al.
Published Erratum
Cell reports. 2026 Feb 18;45(3):117017. DOI:10.1016/j.celrep.2026.117017 2026
Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia [0.03%]
人眼的视动功能由明暗两种途径驱动，并在近视中增强
Urusha Maharjan,Hamed Rahimi-Nasrabadi,Sabina Poudel et al.
Urusha Maharjan et al.
The human eyes are continuously adjusting refractive power, vergence angle, and pupil diameter when exploring the visual environment. Adjustment errors in these visuomotor functions reduce the stimulus contrast driving ON and OFF retinal pa...
A single-cell transcriptional reference for the functional and developmental diversity of neonatal innate lymphoid cells [0.03%]
新生儿固有淋巴细胞功能和发育多样性的单细胞转录参考图谱
Sabrina B Bennstein,Julian Reiß,Katharina Raba et al.
Sabrina B Bennstein et al.
Circulating innate lymphoid cells (cILCs) comprise a complex mixture of subsets with effector functions and progenitor potential toward mature ILCs and natural killer (NK) cells. Here, we dissected cord blood (CB) cILC complexity using sing...
Electroacupuncture suppresses premature ventricular complexes occurring post-myocardial infarction through corticothalamic circuit [0.03%]
电针通过皮质丘脑环路抑制心肌梗死后室性早搏
Fan Zhang,Qian-Yi Wang,Nai-Xuan Wei et al.
Fan Zhang et al.
Published Erratum
Cell reports. 2026 Feb 14;45(2):117070. DOI:10.1016/j.celrep.2026.117070 2026
Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development [0.03%]
胰岛素样生长因子信号调节斑马鱼淋巴管发育
Wenxuan Chen,June P Misa,Caitlin D Herbert et al.
Wenxuan Chen et al.
The coordinated migration of lymphatic endothelial cells (LECs) is essential for the development of the lymphatic network. Here, we uncover the role of the insulin-like growth factor (IGF) signaling pathway in zebrafish lymphatic vessel dev...