Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer [0.03%]
错配修复缺陷产生的胞质DNA结构域协调结直肠癌的抗肿瘤免疫反应
Shayla R Mosley,Natalie Lapa,Afshin Namdar et al.
Shayla R Mosley et al.
Patients with the microsatellite instable (MSI) subtype of colorectal cancer (CRC) have a better prognosis and immunotherapy response than patients with the chromosomally instable (CIN) subtype due to improved cytotoxic T cell responses. Th...
Intracellular bacteria modulate the immune microenvironment of oral squamous cell carcinoma [0.03%]
胞内细菌调节口腔鳞状细胞癌免疫微环境
Yansu Wang,Qiang Lin,Zhongzheng Xiang et al.
Yansu Wang et al.
Neoadjuvant immune checkpoint blockade (NICB) therapy has shown significant efficacy in oral squamous cell carcinoma (OSCC); however, the mechanisms by which intracellular microbiota influence immune function within the tumor microenvironme...
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants [0.03%]
MRAP2通过保守机制增强GPCR信号转导该作用会被肥胖相关基因变异破坏
Aqfan Jamaluddin,Rachael A Wyatt,Johannes Broichhagen et al.
Aqfan Jamaluddin et al.
The melanocortin-2 receptor accessory protein (MRAP) family interacts with and regulates the signaling of diverse G protein-coupled receptors (GPCRs). MRAP2 modifies the signaling of three distinct GPCRs, melanocortin-4 receptor (MC4R), MC3...
Steven C Wyler,Surbhi Gahlot,Lara Bideyan et al.
Steven C Wyler et al.
The G-protein-coupled receptor 75 (GPR75) emerged as a promising therapeutic target for treating diet-induced obesity (DIO). Loss-of-function mutations of GPR75 in humans are associated with reduced body mass index (BMI). Also, Gpr75-defici...
Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch [0.03%]
侧下丘脑调控应激诱导的急性痒和银屑病性慢性痒的表型转换
Jagat Narayan Prajapati,Aynal Hoque,Manojeet Pattanayak et al.
Jagat Narayan Prajapati et al.
Stress modulates itch, with acute stress suppressing and chronic stress exacerbating pruritus, yet the underlying neural mechanisms remain unclear. In this study, we investigate the role of lateral hypothalamic area (LHA) neurons in stress-...
Ash Robbins,Hunter E Schweiger,Sebastian Hernandez et al.
Ash Robbins et al.
Experimental neuroscience techniques are advancing rapidly, with developments in high-density electrophysiology and targeted electrical stimulation enabling single-cell-resolution recording and stimulation. Cortical organoids derived from p...
Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies [0.03%]
纳米级tau聚合物不是跨tau病的共享中间体而是疾病特异性实体
Dorothea Böken,Melissa Huang,Yunzhao Wu et al.
Dorothea Böken et al.
Tauopathies are neurodegenerative diseases marked by pathological tau aggregation. While disease-specific folds of insoluble tau filaments have been established, it remains unclear whether the smaller, earlier species also differ across tau...
Assembly and annotation of hexaploid Sesuviumportulacastrum genome reveals insights into ion transport-mediated high-salinity adaptation [0.03%]
六倍体 SESUVIUM PORTULACASTRUM 基因组的组装与注释提供了盐离子运输介导的高盐度适应性的新见解
Boxuan Yuan,Houli Zhou,Dan Peng et al.
Boxuan Yuan et al.
Soil salinization affects plant growth and global agricultural development, and elucidation of salt tolerance mechanisms can help to enhance crop salt resilience. We combine Oxford Nanopore Technology (ONT) sequencing and second-generation ...
Ca2+-phospholipid-dependent regulation of Munc13-1 is essential for post-tetanic potentiation at mossy fiber synapses and supports working memory [0.03%]
钙离子-磷脂依赖型Munc13-1调节对苔藓纤维突触的 tetanus后增强至关重要，并支持工作记忆
Francisco José López-Murcia,Dilja Krueger-Burg,Sally Wenger et al.
Francisco José López-Murcia et al.
Hippocampal mossy fiber (hMF) to CA3 pyramidal cell synapses are thought to support the formation of working memory through presynaptic short-term facilitation (STF) and post-tetanic potentiation (PTP). However, the molecular mechanisms und...
Adenosine signaling driven by the gut microbiota underlies chronic alcohol-induced anesthetic resistance [0.03%]
肠道微生物群介导的腺苷信号通路是慢性酒精诱导麻醉抵抗的基础
Shuangping Wang,Ling-Yan Su,Danfeng Lan et al.
Shuangping Wang et al.
Chronic alcohol consumption increases anesthetic tolerance, yet the underlying in vivo mechanisms remain unclear. Here, we demonstrate that long-term alcohol exposure reduces anesthetic efficacy in both humans and mice, prolonging induction...