Tissue-resident colon macrophages shape the microbiome and regulate mucosal healing via ferroportin [0.03%]
结肠驻留巨噬细胞通过铁调素形塑肠道菌群并调节黏膜愈合
Bhupendra Singh Rawat,Jaehyeon Kim,Waleed Mujib et al.
Bhupendra Singh Rawat et al.
Inflammatory bowel diseases (IBDs) are complex disorders marked by microbial dysbiosis and dysregulated iron. Iron homeostasis is controlled by endogenous hepcidin, which inhibits iron export through ferroportin, to promote mucosal healing ...
Dynamic acetylation of a metabolic enzyme orchestrates spore stability and germination to facilitate host infection [0.03%]
代谢酶的动态乙酰化调控孢子稳定性和萌发以促进宿主感染
Qianqian Yang,Fugen Yang,Xiaojun Yuan et al.
Qianqian Yang et al.
Fungal spores maintain viability and then germinate to infect host plants, but how these biological processes are integrated remains elusive. Here, we show that γ-carboxymuconolactone decarboxylase 1 (FolCmd1) is an acetylated protein reve...
Blood transcriptome bridges orthogonal immunotypes and gut microbiome enterotypes in humans [0.03%]
人类血液转录组连接人免疫类型和肠道微生物区系类型
Fabio Affaticati,My K Ha,Thies Gehrmann et al.
Fabio Affaticati et al.
Unveiling the systemic effects of disease and health requires a holistic approach that has mainly revolved around well-established, determinable molecular relationships such as the protein synthesis cascade and epigenetic mechanisms. In thi...
H3K18 lactylation drives CD8+ T cell exclusion and anti-PD-1 resistance in hepatocellular carcinoma [0.03%]
肝癌中组蛋白乳酸化促进CD8+T细胞排除及抗PD-1治疗抵抗
Jiang Zhu,Xinye Dai,Ting Luo et al.
Jiang Zhu et al.
Glycolytic metabolism promotes an immunosuppressive microenvironment in HCC, but its role in immunotherapy resistance is unclear. Patients with HCC with high 18F-FDG uptake on PET/CT show reduced anti-PD-1 response. High glycolysis-driven H...
GBP6 maintains mitochondrial bioenergetics to promote immune evasion from NK cells in cervical cancer [0.03%]
GBP6通过维持宫颈癌中的线粒体生物能量促进对NK细胞的免疫逃逸
Lili Qian,Yuebo Li,Jiani Zheng et al.
Lili Qian et al.
Metabolic reprogramming and immune evasion are central hallmarks of cancer progression; yet, how mitochondrial metabolism shapes immune escape remains unclear. Here, we identify GBP6 as a tumor-intrinsic mitochondrial factor associated with...
Mechanistic insights into TAM-mediated OMP assembly in Gram-negative bacteria [0.03%]
TAM介导的阴沟肠杆菌外膜蛋白装配的机制见解
Qinghua Luo,Xintan Dong,Zhaxi Zerang et al.
Qinghua Luo et al.
The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and assembl...
Two's company, three's a crowd: Cross-kingdom competition influences colitis progression [0.03%]
二虎相争，三者相克：跨王国竞争影响结肠炎进展
Vina Manouchehri,Jesús A Romo
Vina Manouchehri
Cross-kingdom interactions in the gastrointestinal tract can influence disease outcomes. In a recent article in Cell Host & Microbe, Zhou et al. describe a mechanism underpinning colitis exacerbation by the fungus Candida albicans governed ...
The Drosophila CEBPG homolog Irbp18 partners with crc (ATF4) to mediate the integrated stress response in degenerative disease models [0.03%]
CEBPG同源物Irbp18与crc（ATF4）结合介导退行性疾病模型中的综合应力反应
Sahana Mitra,Huai-Wei Huang,Rhihab Faruk et al.
Sahana Mitra et al.
The integrated stress response (ISR) coordinates cellular adaptation to diverse stress conditions. In Drosophila, two bZIP transcription factors, Xrp1 and crc (ATF4 homolog), are induced during ISR. Crc protein can dimerize with two CEBP fa...
Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis [0.03%]
猪去氧胆酸诱导巨噬细胞免疫代谢重编程并缓解溃疡性结肠炎
Yaping An,Hu Zhang,Ling Ba et al.
Yaping An et al.
Host-gut microbiota metabolic interactions are implicated in the pathogenesis of ulcerative colitis (UC), but the underlying mechanisms of certain metabolites remain ambiguous. Here, we revealed an impaired bile acid homeostasis in UC with ...
Joyce J I van de Ven,Gimano D Amatngalim,Johan Garssen et al.
Joyce J I van de Ven et al.
The airway epithelium forms the frontline interface between the external environment and the respiratory system and is constantly exposed to microbes and their constituents. Epidemiological and preclinical evidence increasingly highlights a...