Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity [0.03%]
USP39通过稳定PB2和调控核蛋白复合物组装驱动H5型流感病毒的复制和致病性
Hui Yang,Yurui Dong,Ying Bian et al.
Hui Yang et al.
Host cells combat avian influenza virus (AIV) infection by targeting viral polymerase PB2 for degradation, yet how the virus counteracts this remains elusive. In this study, we analyze the host proteins interacting with H5 AIV PB2 and ident...
Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres [0.03%]
局部异染色质富集促进端粒聚集和PML核体在端粒处组装
Erin R Taylor,Bruce Proctor rd,Melina Vaurs et al.
Erin R Taylor et al.
The alternative lengthening of telomeres (ALT) pathway is a recombination-based telomere maintenance mechanism used by a subset of human cancers and is characterized by telomere clustering within telomere-associated promyelocytic leukemia (...
ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia [0.03%]
ACSL4关联的脂质代谢是KMT2A重排急性髓系白血病的独特治疗脆弱性
Silvia Schäfer,Elahe Rahimian,Lola Schmitz-Hübsch et al.
Silvia Schäfer et al.
Deregulated lipid metabolism contributes to leukemogenesis and the progression of acute myeloid leukemia (AML). By analyzing large-scale CRISPR-Cas9 screening data, we identified acyl-CoA synthetase long-chain family member 4 (ACSL4) as a s...
Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms [0.03%]
基于胰腺神经内分泌肿瘤的蛋白质组转录组联合分类和特征鉴定
Kevin C Yang,Steve E Kalloger,John J Aird et al.
Kevin C Yang et al.
Published Erratum
Cell reports. 2026 Feb 18;45(3):117017. DOI:10.1016/j.celrep.2026.117017 2026
Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia [0.03%]
人眼的视动功能由明暗两种途径驱动，并在近视中增强
Urusha Maharjan,Hamed Rahimi-Nasrabadi,Sabina Poudel et al.
Urusha Maharjan et al.
The human eyes are continuously adjusting refractive power, vergence angle, and pupil diameter when exploring the visual environment. Adjustment errors in these visuomotor functions reduce the stimulus contrast driving ON and OFF retinal pa...
A single-cell transcriptional reference for the functional and developmental diversity of neonatal innate lymphoid cells [0.03%]
新生儿固有淋巴细胞功能和发育多样性的单细胞转录参考图谱
Sabrina B Bennstein,Julian Reiß,Katharina Raba et al.
Sabrina B Bennstein et al.
Circulating innate lymphoid cells (cILCs) comprise a complex mixture of subsets with effector functions and progenitor potential toward mature ILCs and natural killer (NK) cells. Here, we dissected cord blood (CB) cILC complexity using sing...
Electroacupuncture suppresses premature ventricular complexes occurring post-myocardial infarction through corticothalamic circuit [0.03%]
电针通过皮质丘脑环路抑制心肌梗死后室性早搏
Fan Zhang,Qian-Yi Wang,Nai-Xuan Wei et al.
Fan Zhang et al.
Published Erratum
Cell reports. 2026 Feb 14;45(2):117070. DOI:10.1016/j.celrep.2026.117070 2026
Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development [0.03%]
胰岛素样生长因子信号调节斑马鱼淋巴管发育
Wenxuan Chen,June P Misa,Caitlin D Herbert et al.
Wenxuan Chen et al.
The coordinated migration of lymphatic endothelial cells (LECs) is essential for the development of the lymphatic network. Here, we uncover the role of the insulin-like growth factor (IGF) signaling pathway in zebrafish lymphatic vessel dev...
NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma [0.03%]
NF1功能丧失在胰腺导管腺癌中的作用
Gopalakrishnan Ramakrishnan,Parash Parajuli,Pura Singh et al.
Gopalakrishnan Ramakrishnan et al.
Published Erratum
Cell reports. 2026 Feb 14;45(2):117066. DOI:10.1016/j.celrep.2026.117066 2026
Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation [0.03%]
EphB4的液-液相分离通过YAP活化驱动肺动脉高压
Jia-Yu Liu,Jing Chen,Qin-Ye Chen et al.
Jia-Yu Liu et al.
Vascular extracellular matrix stiffening is an early and pervasive driver of pulmonary hypertension (PH), though its mechanistic links to pathological cellular responses remain unclear. This study identifies Eph receptor B4 (EphB4), a recep...