Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis [0.03%]
化脓性链球菌代谢产物琥珀酸促进胃癌进展的机制研究
Foqiang Liao,Jianfang Rong,Cong He et al.
Foqiang Liao et al.
Streptococcus anginosus (S. anginosus) has recently been implicated in promoting gastric carcinogenesis, but the underlying mechanism of S. anginosus and its metabolites in gastric carcinogenesis is still unclear. We found that S. anginosus...
Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression [0.03%]
抗病毒核糖核酸酶RNase L通过分解胞质mRNA促进转录抑制作用
Xiaowen Mao,Sherzod Tokamov,Felix Pahmeier et al.
Xiaowen Mao et al.
Ribonuclease (RNase) L is an antiviral factor that promiscuously degrades viral and cellular RNA in the cytoplasm. This results in extensive translational reprogramming, altering mRNA processing and export. Here, we reveal that another majo...
Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration [0.03%]
李斯特菌感染的巨噬细胞促进内皮细胞单层的生物力学改变以利于细菌转移
Marie Muenkel,Kathryn Wright,Erva Keskin et al.
Marie Muenkel et al.
Intracellular pathogens, such as Listeria monocytogenes (LM), manipulate host cells to spread from the initial infection site to distant organs through the bloodstream. For that, LM hijacks mononuclear phagocytes to traverse vascular endoth...
Lingjuan Li,Qun Wang,Xiangzhen Li et al.
Lingjuan Li et al.
Microbial body size is a critical biodiversity trait, determining microbial ecological roles. However, the relationship between microbial community-level body size and microorganism-driven ecosystem performance remains elusive. This study a...
FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages [0.03%]
卵癌中FAK抑制释放欧米茄-3脂肪酸以生成CXCL13抗肿瘤腹膜巨噬细胞
Xiao Lei Chen,Kevin M Tharp,Marjaana Ojalill et al.
Xiao Lei Chen et al.
High-grade serous ovarian cancer (HGSOC) is a lethal malignancy characterized by therapy resistance. Focal adhesion kinase (FAK) is highly expressed in HGSOC, yet its impact on tumor-immune communication remains incompletely defined. Using ...
Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology [0.03%]
利用富含皮层类器官的 corticospinal 运动神经元模拟遗传性痉挛性截瘫 4 型并揭示基因型表型及组蛋白去乙酰胺酶 6 的靶向病理学特征
Neha Mohan,Skandha Ramakrishnan,Xiaohuan Sun et al.
Neha Mohan et al.
Spastic paraplegia 4 (SPG4), the most common form of hereditary spastic paraplegia, causes progressive gait deficiency due to corticospinal tract degeneration. SPG4 results from mutations in the SPAST gene, which encodes spastin, a microtub...
Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication [0.03%]
靶向UGCG通过RAB32介导的内质网-线粒体通信使AML细胞对维奈克拉敏感化作用增强
Xiaofan Sun,Yue Li,Danqi Pan et al.
Xiaofan Sun et al.
Uridine diphosphate (UDP)-glucose ceramide glucosyltransferase (UGCG) is an enzyme that glycosylates ceramide and blunts its pro-apoptotic activity in cancer cells. Targeting UGCG sensitizes solid cancer cells to chemotherapy. However, whet...
Luana Guerra,Melanie Grusdat,Takumi Kobayashi et al.
Luana Guerra et al.
Natural killer (NK) cells are essential for immune protection against tumors and viruses. Disease environments impose oxidative stress and impair immune cell functions. Glutathione (GSH) is a major cellular antioxidant and is critical for t...
Src promotes tumor cell invasion by hijacking the translation machineries [0.03%]
Src通过劫持翻译机制促进肿瘤细胞侵袭
Benjamin Bonnard,Anouk Chatefau,Cyril Dourthe et al.
Benjamin Bonnard et al.
The Src oncogene controls cancer cell invasiveness by promoting invadosome formation and extracellular matrix (ECM) degradation. Invadosomes are translational hotspots enriched in the eukaryotic translation initiation factor 3 (eIF3) comple...
Viral action on the auxin signaling repressor IAA16 reveals a conserved negative regulator of plant growth and immunity [0.03%]
病毒作用于生长素信号抑制子IAA16揭示了一个保守的植物生长和免疫负调控因子
Guan-Ping Chen,Ya-Min Wu,Shi-Xing Zhao et al.
Guan-Ping Chen et al.
Crop breeding endeavors are frequently constrained by the growth-defense trade-off, and uncoupling this trade-off remains challenging due to the limited knowledge of master regulators. Geminivirus-betasatellite complexes, through the betasa...