Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses [0.03%]
ASCC3通过解旋DNA来控制复制压力反应以应对叉子停滞
Shixin Cui,Nicole L Batenburg,Yan Coulombe et al.
Shixin Cui et al.
The activating signal co-integrator 1 complex subunit 3 (ASCC3) is a multifunctional protein. However, little is known about its role in replication stress. Here, we report that ASCC3 is recruited to stalled forks by its binding partner ASC...
FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis [0.03%]
FASN失活诱导的progranulin(GRN)表达通过促进溶酶体依赖性细胞死亡来抑制白血病发生
Meng Su,Qinglin Li,Zhiyi Lv et al.
Meng Su et al.
Cancer cells rely on lipogenesis in addition to exogenous lipid uptake, and fatty acid synthase (FASN) is aberrantly overexpressed in myeloid leukemia, yet its role in leukemogenesis is unclear. We show that FASN is essential for leukemogen...
Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants [0.03%]
蛋白酶激活受体-1的信号偏倚由独特的GRK5和β- arrestin-2决定因素支配
Monica L Gonzalez Ramirez,Lennis B Orduña-Castillo,Carolyne Bardeleben et al.
Monica L Gonzalez Ramirez et al.
G protein-coupled receptors (GPCRs) exhibit signaling bias or preferential activation of heterotrimeric G proteins versus GPCR kinase (GRK)-mediated β-arrestin signaling. The protease-activated receptor-1 (PAR1) activates both G protein an...
Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier [0.03%]
通过阻断Semaphorin 4D诱导的免疫抑制屏障来增强树突状细胞免疫疗法
Saurabh K Garg,Colin Snyder,Ganesan Ramamoorthi et al.
Saurabh K Garg et al.
Immune suppression within the tumor microenvironment (TME) remains a significant barrier to effective cancer immunotherapy, including dendritic cell (DC)-based approaches. We address this by targeting Semaphorin 4D (SEMA4D), a pro-tumorigen...
Structural and functional diversity of toxin-antitoxin-chaperone systems [0.03%]
毒蛋白-抗毒蛋白-分子伴侣系统的结构和功能多样性
Jose A Nakamoto,Roni Odai,Toomas Mets et al.
Jose A Nakamoto et al.
Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecBTA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs ...
Building life from a bigger blueprint: Embryogenesis in whole-organism tetraploids [0.03%]
构建生命的大蓝图：整体四倍体生物的胚胎发育
Alexander T Lessenger,Rebecca Heald
Alexander T Lessenger
Yang et al. show that C. elegans embryos adapt to tetraploidy and maintain viability by scaling their transcriptome proportionately to their increased cell volume. Tetraploids display slower cell cycles and prolonged embryogenesis due to an...
Intracellular buffering enables developmental robustness after genome doubling in C. elegans embryos [0.03%]
细胞内缓冲作用使线虫胚胎在基因组加倍后仍能保持发育稳定性
Miaoling Yang,Yuchuan Bai,Ziyi Wang et al.
Miaoling Yang et al.
Whole-organism polyploidy is widespread across species, yet how embryogenesis adapts to genome doubling remains unclear. Here, we present a systematic single-cell comparison of embryogenesis between de novo-induced tetraploid and diploid C....
Decoding Arabidopsis growth-defense trade-offs through ADR1-associated transcriptional networks [0.03%]
通过ADR1相关转录网络解析拟南芥生长防御权衡关系
Donghui Hu,Jinge Wang,Rachelle R Q Lee et al.
Donghui Hu et al.
Growth and defense are inversely correlated processes requiring balance for fitness. While each is well studied, its regulatory trade-offs are less understood. Using DANGEROUS MIX (DM) autoimmune plants with stunted growth in Arabidopsis th...
A light-responsive transcriptional circuit suppresses sexual reproduction in the rice blast fungus in the field [0.03%]
光照抑制稻瘟病菌田间有性生殖的新机制研究
Hao Liang,Penghui Zhang,Run Gao et al.
Hao Liang et al.
Magnaporthe oryzae, the causal agent of rice blast disease, reproduces asexually in nature but can reproduce sexually under artificial continuous light. How environmental cues regulate this developmental balance has long been unclear. Here,...
Stepwise selection of Tof11/12 and GmRVE1 facilitates soybean adaptation to high-latitude regions [0.03%]
Tof11/12和GmRVE1的渐渗促进大豆对高纬度地区的适应性
Qun Cheng,Jiazhi Yuan,Ying Huang et al.
Qun Cheng et al.
In cultivated soybean, the stepwise selection of genes controlling flowering time and maturity has been crucial for latitudinal adaptation and yield potential. Although the early flowering alleles of tof12 and tof11 are sequentially selecte...