DNA polymerase μ protects macrophages from DNA damage produced during pro-inflammatory activation [0.03%]
DNA聚合酶μ保护巨噬细胞免受促炎激活过程中产生的DNA损伤
Carlos Batlle-Recoder,Lorena Valverde-Estrella,Marta Ferri et al.
Carlos Batlle-Recoder et al.
Activation of macrophages with pro-inflammatory stimuli leads to the generation and secretion of large amounts of reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs). Here, the role of DNA polymerase μ (Polμ), a com...
Katie L Gelder,Nicola A Carruthers,Grace Gilbert et al.
Katie L Gelder et al.
Intrinsically disordered regions (IDRs) are essential regulators of protein function despite lacking stable secondary and tertiary structures. IDRs are integral to the function of multidomain regulatory proteins, such as the essential trans...
Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment [0.03%]
染色质可及性和PCNA募集的调控确保LMNA保护DNA复制起始点
Mengling Zhang,Wenxue Zhao,Zhiguang Xiao et al.
Mengling Zhang et al.
Lamin A/C is essential for maintaining nuclear architecture, organizing chromatin, and preserving genomic stability. However, its role in regulating DNA replication remains unclear. This study investigates how lamin A/C regulates proper rep...
IRE1α regulates macrophage phagocytosis in immune thrombocytopenia through NR1D1 mRNA decay and lysosomal biogenesis [0.03%]
IRE1α通过NR1D1 mRNA降解和溶酶体生物发生调节免疫性血小板减少症中的巨噬细胞吞噬作用
Yushan Xu,Fangling Zhao,Mengjiao Lin et al.
Yushan Xu et al.
Macrophage phagocytosis is essential for immune homeostasis but must be tightly constrained to prevent pathological tissue damage. How cellular stress pathways enforce phagocytic homeostasis remains incompletely understood. Here, we show th...
AlphaFold 3-powered discovery of phage proteins that inhibit bacterial transcription initiation [0.03%]
基于 AlphaFold 3 的噬菌体蛋白发现促进抑制细菌转录起始
Linggang Yuan,Qingyang Liu,Xiaojian Xiao et al.
Linggang Yuan et al.
Many phages encode proteins that specifically inhibit host RNA polymerase activity, thereby sabotaging and, in some cases, hijacking the host transcription machinery to serve their needs. Traditional methods for identifying new phage protei...
Enucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy [0.03%]
携带nectin-1基因的去核细胞能够捕获单纯疱疹病毒并促进其清除用于治疗疱疹性脑膜炎
Lei Zhou,Qingying Song,Mengnian Cao et al.
Lei Zhou et al.
Herpes simplex encephalitis (HSE) is a life-threatening disease of the central nervous system caused by herpes simplex virus type 1 (HSV-1). Despite being a standard treatment, antiviral acyclovir and its derivatives often face limitations ...
De novo recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus [0.03%]
从非洲果蝠中脱 nova恢复加纳病毒，与尼帕病毒相比，加纳病毒具有不同的嗜性和减弱的致病性
Griffin D Haas,Olivier Escaffre,Rebecca A Reis et al.
Griffin D Haas et al.
Henipaviruses (HNVs) like Nipah virus (NiV) and Hendra virus (HeV) represent severe zoonotic threats. Ghana virus (GhV), identified in 2012, is the only African bat henipavirus with a near-complete genome assembly. However, without isolates...
Collagenesis orchestrates mechanoadaptive development and homeostasis of intervertebral discs [0.03%]
胶原蛋白诱导的间盘发育和稳态的力学适应调控
Jian He,Sha Huang,Yangyang Li et al.
Jian He et al.
Intervertebral discs underpin spinal flexibility and stability during locomotion, yet the mechanism guiding their mechanoadaptive development remains inadequately elucidated. Here, we discovered a murine disc type programming spontaneous co...
Single-cell transcriptional and epigenomic landscape of human blood immune cells across the lifespan [0.03%]
人一生中血液免疫细胞的单细胞转录和表观基因组景观
Beibei Huang,Mingming Zhu,Tingting Liang et al.
Beibei Huang et al.
The dynamic changes in immune cell composition throughout the human lifespan remain poorly understood. Here, we performed single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing on peripheral blood m...
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy [0.03%]
拮抗神经元Toll样受体2通过激活自噬防止路易小体病变
Changyoun Kim,Edward Rockenstein,Brian Spencer et al.
Changyoun Kim et al.
Published Erratum
Cell reports. 2026 Mar 11;45(3):117175. DOI:10.1016/j.celrep.2026.117175 2026