TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells [0.03%]
TCR-NF-κB信号激活SENP1-NR4A1轴精调CD8⁺T细胞效应活化
Cen Jiang,Yuquan Yang,Jing Tian et al.
Cen Jiang et al.
T cell receptor (TCR) signaling plays a crucial role in T cell activation by creating a negative controlling mechanism to limit the strength of immune activation; however, the underlying mechanisms remain to be fully elucidated. Here, we id...
Yu Zhang,Mingtao Chen,Xiaohu Lin et al.
Yu Zhang et al.
How cancer cells exploit the tumor microenvironment (TME) to alleviate oxidative stress remains largely unclear. Here, we show that nociceptive neurons, via secretion of epiregulin, increase Lnc-GCLC-1 expression in cancer cells, thereby pr...
Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages [0.03%]
SCAP通过稳定PKM2促进巨噬细胞糖酵解和抗真菌免疫反应
Jiaqi Huang,Yuejue Wang,Fei Li et al.
Jiaqi Huang et al.
Fungal infection induces substantial but poorly understood metabolic reprogramming in macrophages. We demonstrate that fungal stimulation reduces Scap levels in human monocytes and murine bone-marrow-derived macrophages (BMDMs), and Scap de...
TgFbox1-TgNAC2-TgWIN1 module regulates petal senescence by fine-tuning cuticular wax biosynthesis in tulip [0.03%]
唐菖蒲TgFBOX1-TgNAC2-TgWIN1模块通过精细调节角质蜡生物合成调控花瓣衰老
Haipo Yang,Lin Meng,Yue La et al.
Haipo Yang et al.
Flower aging, or senescence, is generally accompanied by petal dehydration/wilting. The cuticle functions as a barrier to withhold water for plant organs. However, little is known about how the cuticle modifies the process of petal developm...
MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution [0.03%]
MSH6通过调控其胞质/核分布来调节cGAS在抗病毒和抗肿瘤信号通路中的活性
Qili Yang,Jinming Kang,Lin Li et al.
Qili Yang et al.
While the cytosolic localization of cGAS is critical for cells to initiate immune responses and protect cells from viral infections, the activity of cGAS in the nucleus is inhibited to prevent autoimmune responses triggered by self-DNA. The...
Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging [0.03%]
单细胞表观遗传组揭示小鼠脑衰老过程中异染色质不稳定性和转录因子功能障碍
Maria Luisa Amaral,Sainath Mamde,Michael Miller et al.
Maria Luisa Amaral et al.
The mechanisms regulating transcriptional changes during brain aging remain poorly understood. Here, we use single-cell epigenomics to profile chromatin accessibility and gene expression across eight mouse brain regions at 2, 9, and 18 mont...
Targeting the DSTYK-ULK1 axis rewires TNFR1 signaling to overcome treatment resistance in lung cancer [0.03%]
靶向DSTYK-ULK1轴重新连接TNFR1信号通路以克服肺癌治疗耐药性
Andrea Pasquier,Cristina Viu-Idocin,Andrea Arricibita et al.
Andrea Pasquier et al.
Immunotherapy has transformed the treatment of non-small cell lung cancer (NSCLC). Yet, acquired resistance remains a major clinical challenge. Defining molecular determinants of tumor sensitivity to T cell-mediated killing is therefore cri...
Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells [0.03%]
G蛋白活化的内向整流性钾通道通过旁分泌抑制调控人类胰岛α细胞的胰高血糖素分泌
Julia K Panzer,Anna L Lang,Noah J Levi et al.
Julia K Panzer et al.
Impaired glucagon secretion from pancreatic alpha cells is a cause of life-threatening hypoglycemia in individuals with type 1 diabetes (T1D). The mechanisms that lead to defective glucagon secretion remain unclear. Here, we show that the h...
Lipocalins regulate development and various stress responses in Physcomitrium patens [0.03%]
唇ocalin调节Physcomitrium patens的发展和各种压力反应
Shuanghua Wang,Jianchao Ma,Qia Wang et al.
Shuanghua Wang et al.
Major physiological and developmental innovations are key to land-plant adaptation and evolution, but their genetic basis remains to be fully understood. Here, we show that lipocalins in the moss Physcomitrium patens regulate various physio...
Enhanced ability to utilize alternative carbon sources drives a competitive advantage for a successful lineage of Klebsiella pneumoniae [0.03%]
利用替代碳源的能力增强驱动克雷伯氏肺炎菌成功谱系的竞争优势
Junna Wang,Yu Feng,Xiaoxia Zhang et al.
Junna Wang et al.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses critical threats to public health, with sequence type 11-capsular type 64 (ST11-KL64) CRKP dominating in China. By comparing the physical properties of ST11-KL64 and its parental linea...