Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer [0.03%]
整合素依赖的中性粒细胞减速通过降低肺灌注量来促进乳腺癌转移
Frédéric Fercoq,Gemma S Cairns,Victoria L Bridgeman et al.
Frédéric Fercoq et al.
Neutrophils are critical in establishing a tumor-cell-nurturing and immunosuppressive pulmonary "pre-metastatic" niche in breast cancer. The localization and behavior of these neutrophils is, however, not well described. Using multiplexed i...
Zhiqi Tian,Rui Chen,Guiqian Fang et al.
Zhiqi Tian et al.
The acidic environment within the lysosome lumen is essential for its digestive function. However, the source of protons responsible for acidification has remained elusive. Here, using a molecular probe to monitor lysosomal digestion, we di...
Orbitofrontal noradrenaline acts as an early gate for reversal learning [0.03%]
顶叶noradrenaline在反转学习早期起筛选作用
Alessandro Piccin,Hadrien Plat,Yacine Tensaouti et al.
Alessandro Piccin et al.
In a dynamic environment, organisms must continuously update learned action-outcome associations. Central to this flexibility is the prefrontal cortex, whose computations are finely tuned by neuromodulatory inputs. Yet, the temporal dynamic...
Gyujin Park,Hojoon Lee
Gyujin Park
Salivation supports oral health, taste sensation, swallowing, and digestion, but the brain mechanisms that regulate this process remain largely unknown. Here, we identify a salivatory center in the mouse brain stem that integrates sensory a...
Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging [0.03%]
单核多组学分析揭示人类前额叶皮质中与衰老相关的基因表达和顺式调控元件
Adam Catching,Cory A Weller,Fangle Hu et al.
Adam Catching et al.
Aging is an unavoidable part of life, but gaps still remain in the understanding of age-associated molecular changes within the brain. We generated single-nucleus multiome ATAC plus gene expression profiles in 357 human brain samples from E...
Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells [0.03%]
辐射诱导的自噬调节纤维母细胞线粒体代谢及其与三阴性乳腺癌细胞串话的作用
Kevin C Corn,Shannon E Martello,Vinay K Menon et al.
Kevin C Corn et al.
Patients with triple-negative breast cancer (TNBC) experience high recurrence rates despite current interventions, which include radiation therapy (RT). Tumor cells thought to be involved in recurrence may survive in part due to their inter...
MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis in early life [0.03%]
MITF程序巨噬细胞铁稳态以驱动生命早期的肠肝炎性轴
Deping Han,Lulu Han,Lingyun Kang et al.
Deping Han et al.
Systemic chronic inflammation (SCI) is a key driver of non-communicable diseases. Early-life stressors disrupt intestinal homeostasis, promoting SCI, but the mechanisms are unclear. Using translational models, we identify dysregulated iron ...
Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment [0.03%]
泛癌进化特征将克隆扩张与肿瘤免疫微环境的动态变化联系起来
Xinyu Yang,Wei Liu,Geoff Macintyre et al.
Xinyu Yang et al.
Cancer is an evolutionary process characterized by profound intratumor heterogeneity (ITH), which can be quantified using in silico estimates of cancer cell fractions (CCFs) of tumor-specific somatic mutations. We demonstrate a data-driven ...
Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation [0.03%]
时空分子谱分析定义了调控炎症发生和消退的关键节点
Katharina Weishaupt,David Chambers,Maria Dzamukova et al.
Katharina Weishaupt et al.
The molecular details of macrophage-fibroblast crosstalk during the onset and resolution of inflammatory disease remain incompletely understood. Here, we apply a bioinformatic modeling approach based on single-cell RNA sequencing and single...
Yu Du,Meilin He,Yixin Xu et al.
Yu Du et al.
Lactate accumulates in large amounts in tumor cells due to the Warburg effect. However, the role of lactate-mediated lactylation, a post-translational modification, in regulating tumor immunity remains unclear. Here, we report that lactate-...