Interhemispheric CA1 projections to the subiculum support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome [0.03%]
半球CA1向subiculum的投射支持空间认知并在22q11.2缺失综合征小鼠模型中受到影响
Noelia S de León Reyes,Maria Helena Bortolozzo-Gleich,Helden Natalia Velez Gonzalez et al.
Noelia S de León Reyes et al.
Mapping hippocampal connectivity is essential to understand the neural mechanisms of learning and memory, yet interhemispheric connections between hippocampal formations remain poorly defined. In rodents, two main commissural pathways are k...
Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics [0.03%]
空间转录组和单细胞转录组解析人类肌腱生命周期的细胞和分子图谱
Alina Kurjan,Jolet Y Mimpen,Lorenzo Ramos-Mucci et al.
Alina Kurjan et al.
Tendon injuries are common and heal poorly, whereas developing tendons repair with minimal scarring; how this capacity declines with age remains poorly understood. Here, we combine histology, single-nucleus, single-cell, and spatial transcr...
Randall S Carpenter,Farzana Begum,Maria K Lagou et al.
Randall S Carpenter et al.
The thymus, a primary lymphoid organ essential for lifelong T cell development, undergoes progressive age-related involution. The thymus is innervated by the sympathetic nervous system (SNS), but the extent of innervation and its relationsh...
The ZmHEAT1/ZmKAKU42-ZmNCH1 module regulates heat stress tolerance by modulating nuclear envelope structure in maize [0.03%]
ZmHEAT1/ZmKAKU42-ZmNCH1模块通过调节核膜结构调控玉米热应激耐受性
Yulong Ji,Shufang Wang,Xiaoliang Wang et al.
Yulong Ji et al.
Heat stress threatens maize production. Through a genome-wide association study using pollen viability decline rate as a phenotype, we identified ZmHEAT1, encoding ZmKAKU41, a nuclear envelope protein known to regulate nuclear morphology in...
Moral inconsistency is based on the vmPFC's insufficient representation across tasks and connectedness [0.03%]
道德一致性不足基于vmPFC在任务中表示不够及联结度不足
Valley Liu,Zhuo Kong,Jiaxin Fu et al.
Valley Liu et al.
Moral inconsistency-misaligning one's behavior with the same moral principle of judging others-undermines personal reputations and social relationships. This study explores the neural underpinnings of moral inconsistency in a profit-honesty...
Subtyping based on hippocampal cryptic exon burden reveals proteome-wide changes associated with TDP-43 and Alzheimer's disease pathology [0.03%]
基于海马隐秘外显子负荷的亚型划分揭示了与TDP-43和阿尔茨海默病病理相关的蛋白质组变化
Adam N Trautwig,Anantharaman Shantaraman,Mingee Chung et al.
Adam N Trautwig et al.
TDP-43 pathology defines limbic-predominant age-related TDP-43 encephalopathy (LATE-NC) and frequently co-occurs with Alzheimer's disease neuropathologic change (ADNC), yet the molecular consequences of overlapping pathology remain unclear....
GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits [0.03%]
胃泌素受体激动通过不同的神经环路抑制炎症诱导的负性情绪和摄食减少
Haley S Province,Nikolas W Hayes,Nathan A Leong et al.
Haley S Province et al.
Glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin hormone, and pharmacologic modulation of central GIP receptors (GIPRs) improves energy homeostasis and prevents conditioned taste avoidance (CTA). However, the mec...
Keyan He,Lixuan Liu,Junxiang Luo et al.
Keyan He et al.
Objects move through space and time, generating sequential visuotopic activations in all sighted animals, leading to velocity perception defined by direction and speed. The primary visual cortex (V1) only encodes directionality at low speed...
Aberrant multicellular interferon signaling underlies Adar1 mutation-driven Aicardi-Goutières syndrome-like encephalopathy [0.03%]
ADAR1基因突变通过异常的多细胞干扰素信号通路导致Aicardi-Goutières综合征样脑病
Hyebin Yoo,Taisuke Nakahama,Reiichi Sugihara et al.
Hyebin Yoo et al.
Adenosine-to-inosine RNA editing by ADAR1 prevents aberrant innate immunity activation by modifying endogenous double-stranded RNA. Mice carrying a left-handed double-stranded RNA (Z-RNA) binding-deficient mutation develop Aicardi-Goutière...
ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis [0.03%]
ALG6通过内质网压力-自噬轴调控冠状病毒复制
Yanan Fu,Meijie Gao,Zhen Fu et al.
Yanan Fu et al.
Coronaviruses (CoVs) constitute a major global health threat, and their replication is inseparable from host factors. Investigating host-virus interactions is critical for elucidating the CoV life cycle. Here, we identify alpha-1,3-glucosyl...