The coordinated actions of metformin in the intestine and liver improves hyperglycemia [0.03%]
肠道和肝脏协同作用改善二甲双胍的降糖效果
Ling He,Hongying An,Karina Ramirez et al.
Ling He et al.
Metformin is the first-line oral anti-diabetic agent. Metformin concentrations in the intestine can reach up to 1.3 mM, while those in the portal vein are approximately 0.075 mM. It is unclear whether this metformin concentration difference...
Aanchal Bhatia,Mohamed Adel,Christine Grienberger
Aanchal Bhatia
The hippocampus is essential for spatial learning, yet how its principal output structure, the subiculum, encodes behaviorally relevant information during navigation remains poorly understood. Because subicular neurons exhibit prominent bur...
Adrija Pathak,Gregg B Wells,Vytas A Bankaitis et al.
Adrija Pathak et al.
Pediatric high-grade gliomas (HGGs) exhibit genetic profiles accompanied by anatomical specificities. These features suggest that specific anatomical niches favor the onset and/or progression of these diseases. However, such niche identitie...
A CEBPB-IPO4-FASN-MAVS axis limits innate immune activation and viral pneumonia [0.03%]
CEBPB-IPO4-FASN-MAVS轴限制先天免疫激活和病毒性肺炎发生
Jing Wu,Zihan Chen,Shengxiang Yin et al.
Jing Wu et al.
Dysregulation of innate immunity during respiratory RNA virus infections drives systemic hyperinflammation and lung injury. Here, we show that importin β4 (IPO4) has a role in inhibiting antiviral innate immunity. Transcriptomics analysis ...
ID2 Unlocks retinoic acid signaling to promote eosinophil maturation by antagonizing TCF3 [0.03%]
ID2通过拮抗TCF3促进视黄酸信号通路促进嗜酸性粒细胞成熟
Yubing Huang,Hao Wen,Jing Li et al.
Yubing Huang et al.
Novel functions of eosinophils are continually being discovered, yet the regulatory mechanisms underlying eosinophil development-particularly how ubiquitous nutrient metabolites integrate with cell-intrinsic transcriptional programs-remain ...
Circulating cochlin LCCL domain binds to dying cells and enhances efferocytosis [0.03%]
循环中的耳蛋白LCCL结构域结合于细胞凋亡体并增强其内吞作用
Louise Courcol,Ali Hassan,Zofia Haftek-Terreau et al.
Louise Courcol et al.
Clearance of dead cells by efferocytosis is a critical process for homeostasis, notably by limiting inflammation. Defective efferocytosis has been associated with autoimmune, neurodegenerative, and cardiovascular diseases, as well as chroni...
Telomere-to-telomere genome assembly of yellow-seeded rapeseed reveals BnaSCC1 regulates seed coat color and oil accumulation [0.03%]
油菜端粒到端粒基因组组装揭示BnaSCC1调控种皮颜色和油脂积累
Haijiang Liu,Kaijie Ye,Yiwen Xie et al.
Haijiang Liu et al.
Yellow-seeded rapeseed has higher oil content and seed quality than black-seeded varieties, but its genetic basis remains unclear. We report a telomere-to-telomere genome assembly of yellow-seeded rapeseed GH06 (981.18 Mb; contig N50, 56.93...
A telomere-to-telomere Brassica napus genome identifies BnaWRKY44 regulation of seed coat color and oil [0.03%]
一个端到端的油菜（Brassica napus）基因组鉴定出BnaWRKY44调节种子种皮颜色和油脂含量
Haijiang Liu,Yongheng Yuan,Kaijie Ye et al.
Haijiang Liu et al.
Brassica napus yellow-seeded genotypes have higher seed oil content and quality than black-seeded types, but the mechanisms controlling seed coat color (SCC) remain unclear, partly due to limited gap-free references. We generated the telome...
The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages [0.03%]
丙型肝炎病毒E1E2糖蛋白复合物保守的桥接区是中和抗体作用的关键位点
Fang Chen,Yen Thi Kim Nguyen,Yi-Zong Lee et al.
Fang Chen et al.
The bridging domain (BD) region on hepatitis C virus (HCV) E1E2 glycoprotein complex is a conserved, E1-dependent conformational site of vulnerability formed by E2 residues 646-704. Given its importance for rational vaccine design, here, we...
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis [0.03%]
磷脂稳态调节磷脂酰丝氨酸合成介导的IP3R依赖性内质网钙释放
Yifan Zhou,Meng Diao,Yaqiang Liu et al.
Yifan Zhou et al.
Regulation of phospholipid composition is essential for cellular homeostasis. Phosphatidylserine (PS) synthesized in the endoplasmic reticulum (ER) plays critical roles in the plasma membrane and endolysosomal system. Although aberrant PS m...